Oocyte destruction and ovarian tumorigenesis after direct application of a chemical carcinogen (9:10‐dimethyl‐1:2‐benzanthrene) to the mouse ovary

Abstract

Ovaries of immature mice were painted with 9:IO-dimethyl-l:2-benzanthracene ( D M B A ) , and the effect of the carcinogen on the number of oocytes as well as

Effects of carcinogen and/or mutagen on normal and gonadotropin‐primed ovaries of mice

“…This finding of the present study conforms with the observations of Krarup (1970a) and Krarup and Loff (1971). Depletion of the oocytes by DMBA treatment is followed by ovarian tumorigenesis (Krarup, 1967(Krarup, , 1970b.…”

STP Position Paper: Ovarian Follicular Counting in the Assessment of Rodent Reproductive Toxicity

“…Ongoing apoptosis or necrosis and decreases in the reserve pool of small follicles usually are detectable by qualitative microscopic examination. Degeneration of oogonia in utero or in the immediate postnatal period may cause significant depletion of primordial follicles that would likely be further exacerbated in adults due to continued recruitment for growth from the already depleted primordial pool (Mandl and Zuckerman, 1952;Krarup, 1969;Murphy and Beamer, 1973;Hirshfield, 1994). These changes are discernible to a pathologist conducting a focused qualitative examination of the ovary.…”

Mechanisms of Ovarian Atresia Induced by Xenobiotic Exposures

“…A number of studies have shown that exposure to ovarian toxicants can lead to oocyte destruction Krarup et al, 1967;1969;1970;Maronpot, 1987;Melnick et al, 1990). How these effects are produced is becoming better understood and detailed for a number of chemical classes discussed herein.…”