Online Internet-based robotic telepathology in the diagnosis of neuro-oncology cases: A teleneuropathology feasibility study

Szymaś, Janusz; Wolf, Guenther; Papierz, W; Jarosz, Bożena; Weinstein, Ronald S.

doi:10.1053/hupa.2001.29647

Cited by 28 publications

(22 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, we think that although our findings showed that the level of interobserver agreement in the diagnosis of dysplasia in CUC by TP is, at best, fair, and needs significant improvement, based on the criteria available at this time, we believe that the diagnostic consultation of these cases by dynamic TP is an acceptable alternative to traditional glass slide analysis. This statement is further supported by the results of other studies which have observed a high level of diagnostic accuracy with the use of either static or dynamic-based TP systems utilizing pathology material other than GI mucosal biopsies (2)(3)(4)(5)8,(19)(20)(21)(22). These studies have included the evaluation of inter-operative frozen sections, prostate needle biopsies, and pulmonary and neuropathology cases.…”

Section: Reviewersupporting

confidence: 61%

Variability in the diagnosis of dysplasia in ulcerative colitis by dynamic telepathology

et al. 2006

View full text Add to dashboard Cite

Abstract. Telepathology (TP) is the practice of evaluating pathology cases by the digital transmission of diagnostic slides as either static pictures (static TP) or by a continuous flow of pictures from a robotic microscopy (dynamic TP). The diagnostic efficacy of dynamic TP-based consultation services has not been widely tested. Dysplasia arising in association with chronic ulcerative colitis (CUC) is, at present, the most important marker for an increased risk of malignancy in patients with this disease. However, the diagnosis of dysplasia suffers from a significant degree of intra-and interobserver variability which usually necessitates a second opinion prior to definitive treatment. Thus, it is often necessary to obtain expert consultation of potential dysplasia cases by dedicated gastrointestinal pathologists. The aim of this study was to evaluate the utility and interobserver variability of diagnosing dysplasia in CUC with the use of dynamic TP. Dynamic TP was used to evaluate digitalized images of 38 CUC cases with areas considered negative, indefinite, or positive for dysplasia (low or high grade) independently by seven pathologists. Subsequently, all cases were graded by each of the pathologists by light microscopic examination of the H&E-stained glass slides. The degree of intra-and interobserver variability was determined by Kappa statistics. Overall, there was a poor degree of interobserver agreement (K=0.32) among the seven pathologists after analysis of the cases by dynamic TP. The poorest level of agreement was in the indefinite and lowgrade dysplasia categories, whereas the highest level was in the negative and high-grade dysplasia categories. Grouping together several diagnostic categories (for instance: Indefinite and low, or low-and high-grade dysplasia) had no significant effect on the level of agreement. The degree of variability in interpretation of cases by microscopic slide analysis was similar (K=0.35). After reviewing all the cases by microscopic analysis of the glass slides, the diagnosis was changed in 51% of the observations; in the majority of these (61%), the grade of dysplasia was decreased. In summary, the use of dynamic TP for consultation in CUC-associated dysplasia has a poor level of interobserver agreement, but does not differ significantly from that obtained by the evaluation of the cases by microscopic slide analysis. Diagnoses rendered by dynamic TP tend to be of a higher grade compared to that obtained by microscopic slide analysis. Thus, although dynamic TP may be used for the consultation of CUC dysplasia cases, more specific criteria are needed in the general categorization of dysplasia in CUC.

show abstract

Section: Reviewersupporting

confidence: 61%

Variability in the diagnosis of dysplasia in ulcerative colitis by dynamic telepathology

et al. 2006

View full text Add to dashboard Cite

show abstract

“…Viewing virtual slides over the Internet would circumvent such logistical issues and could increase the availability of immediate access to subspecialty pathology consultative services. 54 The ultrarapid virtual slide scanner may prove to be important for cancer clinical trials as well as the other clinical trials requiring pathology reviews. The practice of retrospective re-review of the surgical pathology slides upon which a diagnosis was initially established at a contributing institution, and which served as the basis for a protocol case assignment, may finally be replaced by a prospective review process.…”

Section: Applications Of Array Microscopes and Next-generation Ultrarmentioning

confidence: 99%

An array microscope for ultrarapid virtual slide processing and telepathology. Design, fabrication, and validation study

et al. 2004

Self Cite

View full text Add to dashboard Cite

“…Static image telepathology is an accessible technique that can also be used in developing countries. Newer and more time-consuming techniques like WSI and virtual microscopy are superior to static image pathology with a diagnostic accuracy between 91-100% compared to conventional light microscopy [Szymas et al, 2001;Kaplan et al, 2002;Leong et al, 2002;Li et al, 2008;Evans et al, 2009b;Pantanowitz et al, 2012;Campbell et al, 2014;Shah et al, 2016]. Diagnostic accuracy can be improved by experience in a subspecialty and electronic consultation [Williams et al, 2001].…”

Section: Low Accuracy Of Diagnosis In Telepathologymentioning

confidence: 99%

Histological Assessment of Gonads in DSD: Relevance for Clinical Management

Spoor

Oosterhuis²,

Hersmus³

et al. 2017

Sex Dev

View full text Add to dashboard Cite

Malignant gonadal germ cell tumors, referred to as germ cell cancers (GCC), occur with increased frequency in individuals who have specific types of differences (disorders) of sex development (DSD). Recent population-based studies have identified new environmental and genetic risk factors that have led to a ‘genvironment' hypothesis, which may potentially be helpful in risk assessment in DSD-related GCC. In DSD, the malignancy risk is highly heterogeneous, but recent studies allow now to discriminate between high- and low-risk conditions. Gonadal biopsy is in some cases the best procedure of choice to assess the risk, and with the availability of immunohistochemical biomarkers [OCT3/4 (POU5F1), TSPY, SOX9, FOXL2 and KITLG (SCF)], a reliable classification of GCC and its precursors can be made. The opportunities in the field of virtual diagnostic pathology will be presented, having possibilities for rare diseases in general and DSD specifically. It is expected that the International DSD Registry will stimulate international collaborations, facilitating better diagnostic procedures as well as research.

show abstract

Online Internet-based robotic telepathology in the diagnosis of neuro-oncology cases: A teleneuropathology feasibility study

Cited by 28 publications

References 9 publications

Variability in the diagnosis of dysplasia in ulcerative colitis by dynamic telepathology

Variability in the diagnosis of dysplasia in ulcerative colitis by dynamic telepathology

An array microscope for ultrarapid virtual slide processing and telepathology. Design, fabrication, and validation study

Histological Assessment of Gonads in DSD: Relevance for Clinical Management

Contact Info

Product

Resources

About