An array microscope for ultrarapid virtual slide processing and telepathology. Design, fabrication, and validation study

Weinstein, Ronald S.; Descour, Michael R.; Liang, Chunjun; Barker, Gail; Scott, Katherine; Richter, Lynne; Krupiński, Elizabeth A.; Bhattacharyya, Achyut K.; Davis, John R.; Graham, Anna R.; Rennels, Margaret A.; Russum, William C.; Goodall, James F.; Zhou, Pixuan; Olszak, Artur G.; Williams, Bruce H.; Wyant, James C.; Bartels, Peter H.

doi:10.1016/j.humpath.2004.09.002

Cited by 158 publications

(82 citation statements)

References 51 publications

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“…Integrating WSI into retrospective data analysis is imminently feasible, 23,24 and while it may require customization of annotation software, such systems are already commercially available (www.aperio.com or www.pixcelldata.com; accessed March 30, 2012).…”

Section: Discussionmentioning

confidence: 99%

“…Some vendors have devices that use nontraditional optics, illumination, and sensors, which are designed specifically for ultrahigh speed image capture. 15,[23][24][25][26][27] The components of an automated WSI system include an optical microscope system with a camera, an acquisition system, computer hardware/software, scanning software, and the digital slide viewer. Supplemental components include the feeder and image processing systems.…”

Section: Whole Slide Imaging and Its Application In Pathologymentioning

confidence: 99%

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Central Pathology Review for Phase III Clinical Trials: The Enabling Effect of Virtual Microscopy

Mróz

Parwani

Kulesza

2013

Archives of Pathology &Amp; Laboratory Medicine

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Context.—Central pathology review (CPR) was initially designed as a quality control measure. The potential of CPR in clinical trials was recognized as early as in the 1960s and quickly became embedded as an integral part of many clinical trials since. Objective.—To review the current experience with CPR in clinical trials, to summarize current developments in virtual microscopy, and to discuss the potential advantages and disadvantages of this technology in the context of CPR. Data Sources.—A PubMed (US National Library of Medicine) search for published studies was conducted, and the relevant articles were reviewed, accompanied by the authors' experience at their practicing institution. Conclusions.—The review of the available literature strongly suggests the growing importance of CPR both in the clinical trial setting as well as in second opinion cases. However, the currently applied approach significantly impedes efficient transfer of slides and patient data. Recent advances in imaging, digital microscopy, and Internet technologies suggest that the CPR process may be dramatically streamlined in the foreseeable future to allow for better diagnosis and quality assurance than ever before. In particular, whole slide imaging may play an important role in this process and result in a substantial reduction of the overall turnaround time required for slide review at the central location. Above all, this new approach may benefit the large clinical trials organized by oncology cooperative groups, since most of those trials involve complicated logistics owing to enrollment of large number of patients at several remotely located participating institutions.

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Section: Discussionmentioning

confidence: 99%

Section: Whole Slide Imaging and Its Application In Pathologymentioning

confidence: 99%

Central Pathology Review for Phase III Clinical Trials: The Enabling Effect of Virtual Microscopy

Mróz

Parwani

Kulesza

2013

Archives of Pathology &Amp; Laboratory Medicine

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“…To date, only one technique has been developed and commercialized for automated tissue slide microimaging . The key device is a 2D array of 8 × 10 miniature microscopic objectives overlaid by a specially designed CMOS imaging sensor (Weinstein et al, 2004(Weinstein et al, , 2005. This miniature digital-optical microimaging device can produce image data in the form of 80 strips simultaneously, so one scan of the slide could form an entire digital slide.…”

Section: Array Microscopy Imagingmentioning

confidence: 99%

“…Due to the fixed precise arrangement of the optic/imaging-sensor elements, all strips are stitched together during the scan. With the parallel optical-digital imaging approach, an ultrarapid scan (∼58 sec) of an entire slide can be achieved (Weinstein et al, 2004). A weakness of this ultrarapid automated scanning with fixed miniature objectives is the difficulty ensuring accurate local focusing.…”

Section: Array Microscopy Imagingmentioning

confidence: 99%

“…7, 2006 BIOIMAGING IN TOXICOLOGIC PATHOLOGY 819 with VMR and the software. It would be anticipated that "slide read time" would decrease with more experience using VMR and, in fact, significantly higher slide reading speed was shown with virtual slides in several clinical pathology studies (Molnar et al, 2003;Weinstein et al, 2004;Burthem et al, 2005).…”

Section: Comparison Of the Vmr And Omrmentioning

confidence: 99%

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Modern Imaging Technologies in Toxicologic Pathology: An Overview

Ying

Monticello

2006

Toxicol Pathol

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Modern imaging technology, now utilized in most biomedical research areas (bioimaging), enables the detection and visualization of biological processes at various levels of the molecule, organelle, cell, tissue, organ and/or whole body. In toxicologic pathology, the impact of modern imaging technology is becoming apparent from digital histopathology to novel molecular imaging for in vivo studies. This overview summarizes recent progresses in digital microscopy imaging and newly developed digital slide techniques. Applications of virtual microscopy imaging are discussed and compared to traditional optical microscopy reading. New generation digital pathology approaches, including automatic slide inspection, digital slide databases and image management are briefly introduced. Commonly used in vivo preclinical imaging technologies are also summarized. While most of these new imaging techniques are still undergoing rapid development, it is important that toxicologic pathologists embrace and utilize these technologies as advances occur.

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2013

Microrobotics for Micromanipulation

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An array microscope for ultrarapid virtual slide processing and telepathology. Design, fabrication, and validation study

Cited by 158 publications

References 51 publications

Central Pathology Review for Phase III Clinical Trials: The Enabling Effect of Virtual Microscopy

Central Pathology Review for Phase III Clinical Trials: The Enabling Effect of Virtual Microscopy

Modern Imaging Technologies in Toxicologic Pathology: An Overview

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