One thousand seventy-eight autologous IVF cycles in women 45 years and older: the largest single-center cohort to date

Gunnala, V.; Irani, Mohamad; Melnick, A.P.; Rosenwaks, Zev; Spandorfer, Steven D.

doi:10.1007/s10815-017-1088-y

Cited by 31 publications

(17 citation statements)

References 30 publications

(27 reference statements)

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“…There were no live births in patients that had less than four oocytes retrieved. Other predictors (beside age) of positive pregnancy in women >45 years in their study were day 3 FSH and AMH levels, the number of of mature oocytes, the number of fertilized oocytes (2PN) and the number of embryos transferred (28).…”

Section: Discussionmentioning

confidence: 96%

Predictive factors for live birth in autologous in vitro fertilization cycles in women aged 40 years and older

Reljič

Lovrec

2019

Slovenian Journal of Public Health

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Background The aim of the study was to determine predictive factors for live birth after in vitro fertilization with autologous oocytes in women ≥40 years of age. Methods Authors conducted a retrospective analysis of in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) cycles performed at the Department of Reproductive Medicine and Gynecologic Endocrinology, University Medical Centre Maribor, Slovenia between January 2006 and December 2015 in women aged 40 or more. The characteristics of patients and cycles were compared regarding live birth as the final outcome. Results A total of 1920 IVF/ICSI cycles with egg retrieval in women ≥40 years of age were performed leading to 1591 embryo transfers. The live birth rate per embryo transfer was 17.3% at 40, 11.6% at 41, 8.2% at 42, 7.9% at 43, 1.9% at 44 and 0.0% at ≥45 years of age. The multivariate logistic regression model showed that besides women’s age (OR 0.66, 95% CI: 0.55–0.78), the number of previous cycles (OR 0.88, 95% CI: 0.82–0.95), number of good quality embryos on day 2 (OR 1.19, 95% CI: 1.05-1.36), number of embryos transferred (OR 1.57, 95% CI: 1.19–2.07) and day 5 embryo transfer (OR 2.21, 95% CI: 1.37–3.55) were also independent prognostic factors for live birth. Conclusions The chance of in vitro fertilization success in women ≥40 years of age should not be estimated only on the woman’s age, but also on other predictive factors: number of previous cycles, number of good quality embryos on day 2, number of transferred embryos and blastocyst embry transfer.

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Section: Discussionmentioning

confidence: 96%

Predictive factors for live birth in autologous in vitro fertilization cycles in women aged 40 years and older

Reljič

Lovrec

2019

Slovenian Journal of Public Health

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“…123 The range of ages is quite different in each study, some focusing on older patients 107 while others targeting on the younger population (<38 years old). Infertile patients with unknown history of IVF-ET, women undergoing the first cycle of IVF/ ICSI-ET, and women with implantation failure were the three main populations studied for IUI-hCG.…”

Section: Population Differencementioning

confidence: 99%

“…Also, age is a well-known factor for the success of IVF-ET. 123 The range of ages is quite different in each study, some focusing on older patients 107 while others targeting on the younger population (<38 years old). 113 In addition, pre-implantation genetic screening, 104 number of transferred embryos, and embryo quality are factors that can variate in each trial.…”

Section: Population Differencementioning

confidence: 99%

Intrauterine infusion of human chorionic gonadotropin before embryo transfer in IVF/ET cycle: The critical review

Zhang

Chen

Wang

et al. 2019

American J Rep Immunol

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Intrauterine infusion of human chorionic gonadotropin (IUI‐hCG) has been proposed to improve the outcome of in vitro fertilization‐embryo transfer (IVF‐ET), since it plays a critical role in synchronizing endometrial and fetal development. As the early mediator from embryo, hCG promotes the decidualization, angiogenesis, maternal immune tolerance, and trophoblast invasion, favoring successful implantation of embryo. Although multiple clinical trials have been conducted to verify the efficacy of IUI‐hCG on IVF‐ET outcome in recent years, the findings remained controversial. The difference in study design and population might be the cause to the different consequences after administration of hCG. More importantly, the endometrial receptivity, which might affect the efficacy of IUI‐hCG, has not been assessed in women receiving this intervention. Selecting the right population suitable for IUI‐hCG based on known etiology would be crucial in enhancing its efficacy and minimize any possible complications. Investigation of optimal indications for IUI‐hCG should be highlighted in the future.

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“…Многие авторы изучали риск опухолей центральной нервной системы (ЦНС) после ВРТ по сравнению с группой детей, родившихся после спонтанных беременностей [16]. Метаанализ из 25 исследований показал, что у детей после ВРТ риск развития рака ЦНС не был достоверно повышен по сравнению с детьми, родившимися после спонтанной беременности [1]. Также S.R.…”

Section: эпигенетические нарушенияunclassified

“…Последние годы показатель рождаемости детей от женщин 30-44 лет неуклонно возрастает. Так, с 2007 г. отмечается увеличения количества родов у женщин старше 40 лет на 15%, у женщин в возрасте 36-39 лет и 30-34 лет -на 9 и 1%, соответственно [1]. Однако с возрастом фертильная функция снижается, и многие пары сталкиваются с проблемой бесплодия.…”

Section: Introductionunclassified

The health status of children born through assisted reproductive technologies: probable risks and possible complications

Pitskhelauri

Стрижаков

Timokhina

et al. 2018

Akušerstvo, ginekologiâ i reprodukciâ

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Most of the negative consequences for the health and development of children born through assisted reproductive technologies are related to health status of their mothers, i.e. infertility, age and the related metabolic, genetic and epigenetic changes affecting the quality of gametes and pregnancy. Improvement of the current techniques of in vitro fertilization, preimplantation genetic diagnosis and other preventive measures will have a favorable effect on the health status of such children.

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One thousand seventy-eight autologous IVF cycles in women 45 years and older: the largest single-center cohort to date

Abstract: Autologous IVF in women aged 45 with acceptable ovarian reserve is not futile; however, it does carry very low prognosis. Patients aged 46 and older should be counseled appropriately that a live birth seems highly unlikely.

Cited by 31 publications

References 30 publications

Predictive factors for live birth in autologous in vitro fertilization cycles in women aged 40 years and older

Predictive factors for live birth in autologous in vitro fertilization cycles in women aged 40 years and older

Intrauterine infusion of human chorionic gonadotropin before embryo transfer in IVF/ET cycle: The critical review

The health status of children born through assisted reproductive technologies: probable risks and possible complications

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