Predictive factors for live birth in autologous in vitro fertilization cycles in women aged 40 years and older

Abstract

Background The aim of the study was to determine predictive factors for live birth after in vitro fertilization with autologous oocytes in women ≥40 years of age. Methods Authors conducted a retrospective analysis of in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) cycles performed at the Department of Reproductive Medicine and Gynecologic Endocrinology, University Medical Centre Maribor, Slovenia between January 2006 and December 2015 in women aged 40 or more. The characteristics of patients and cycles were compared regarding live birth as the final outcome. Results A total of 1920 IVF/ICSI cycles with egg retrieval in women ≥40 years of age were performed leading to 1591 embryo transfers. The live birth rate per embryo transfer was 17.3% at 40, 11.6% at 41, 8.2% at 42, 7.9% at 43, 1.9% at 44 and 0.0% at ≥45 years of age. The multivariate logistic regression model showed that besides women’s age (OR 0.66, 95% CI: 0.55–0.78), the number of previous cycles (OR 0.88, 95% CI: 0.82–0.95), number of good quality embryos on day 2 (OR 1.19, 95% CI: 1.05-1.36), number of embryos transferred (OR 1.57, 95% CI: 1.19–2.07) and day 5 embryo transfer (OR 2.21, 95% CI: 1.37–3.55) were also independent prognostic factors for live birth. Conclusions The chance of in vitro fertilization success in women ≥40 years of age should not be estimated only on the woman’s age, but also on other predictive factors: number of previous cycles, number of good quality embryos on day 2, number of transferred embryos and blastocyst embry transfer.

Association between sociodemographic, obstetric, and lifestyle factors among Hungarian pregnant women—A cross‐sectional study

“…28 Nonetheless, compulsory genetic pregnancy screenings over 35 years can also lower the health risks. 29 Our results show that advanced maternal age is associated with the examined lifestyle fields, except for alcohol consumption during pregnancy. Mothers 25-34 years of age with higher educational level, in nonsingle partnership, living in county towns showed more frequent physical activity.…”

“…Advanced age women tend to consume less unhealthy snacks and drinks during pregnancy compared with younger mothers 28 . Nonetheless, compulsory genetic pregnancy screenings over 35 years can also lower the health risks 29 . Our results show that advanced maternal age is associated with the examined lifestyle fields, except for alcohol consumption during pregnancy.…”

Prognostic value of a serum β-hCG cut off, 12 days after fresh embryo transfer, on predicting live birth among Ugandan women

“…Considering the nancial and psychosocial cost of ART, any outcome other than a live birth would not be desired. Maternal age, previous IVF (In vitro fertilization) attempts, number of good quality embryos, number of embryos transferred and blastocyst transfer are prognostic factors for live birth [14]. Others include Anti-Mullerian hormone (AMH) levels and antral follicle count (AFC) [15].…”

Prognostic value of a serum β-human chorionic gonadotropin cutoff, twelve days after fresh embryo transfer, on predicting live birth among Ugandan women

“…Considering the financial and psychosocial cost of ART, any outcome other than a live birth would not be desired. Maternal age, previous in vitro fertilization (IVF) attempts, number of good quality embryos, number of embryos transferred, and blastocyst transfer are prognostic factors for live birth [14] . Others include anti-Mullerian hormone levels and antral follicle count [15] .…”