One‐Step Immobilization of Protein‐Encapsulated Core/Shell Particles onto Nanofibers

Park, Chul Ho; Lee, Jonghwi

doi:10.1002/mame.201000039

Cited by 16 publications

(17 citation statements)

References 56 publications

(52 reference statements)

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“…[11][12][13] It has been applied in controlling secondary structures of nanofibers, encapsulating drugs or biological agents into the polymeric nanofibers, fabricating polymeric microtubes, preparing nanofibers from materials that lack filament-forming properties, and enclosing functional liquids within the fiber matrix. [14][15][16][17][18] In traditional coaxial electrospinning, the sheath solution acts as a guide and surrounds the core material, which means that the sheath fluids must be electrospinnable and have enough viscosity to overcome the interfacial tension between the two solutions through "viscous dragging" and "contact friction" for a successful coaxial process. 17,18 More recently, a modified process based on coaxial electrospinning was reported, in which only unspinnable solvents were used as sheath fluids.…”

Section: Introductionmentioning

confidence: 99%

Polyacrylonitrile nanofibers coated with silver nanoparticles using a modified coaxial electrospinning process

Yu¹,

Zhou²,

Chatterton³

et al. 2012

IJN

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Background:The objective of this investigation was to develop a new class of antibacterial material in the form of nanofibers coated with silver nanoparticles (AgNPs) using a modified coaxial electrospinning approach. Through manipulation of the distribution on the surface of nanofibers, the antibacterial effect of Ag can be improved substantially. Methods: Using polyacrylonitrile (PAN) as the filament-forming polymer matrix, an electrospinnable PAN solution was prepared as the core fluid. A silver nitrate (AgNO 3 ) solution was exploited as sheath fluid to carry out the modified coaxial electrospinning process under varied sheath-to-core flow rate ratios. Results: Scanning electron microscopy and transmission electron microscopy demonstrated that the sheath AgNO 3 solution can take a role in reducing the nanofibers' diameters significantly, a sheath-to-core flow rate ratio of 0.1 and 0.2 resulting in PAN nanofibers with diameters of 380 ± 110 nm and 230 ± 70 nm respectively. AgNPs are well distributed on the surface of PAN nanofibers. The antibacterial experiments demonstrated that these nanofibers show strong antimicrobial activities against Bacillus subtilis Wb800, and Escherichia coli dh5α. Conclusion: Coaxial electrospinning with AgNO 3 solution as sheath fluid not only facilitates the electrospinning process, providing nanofibers with reduced diameters, but also allows functionalization of the nanofibers through coating with functional ingredients, effectively ensuring that the active antibacterial component is on the surface of the material, which leads to enhanced activity. We report an example of the systematic design, preparation, and application of a novel type of antibacterial material coated with AgNPs via a modified coaxial electrospinning methodology.

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Section: Introductionmentioning

confidence: 99%

Polyacrylonitrile nanofibers coated with silver nanoparticles using a modified coaxial electrospinning process

Yu¹,

Zhou²,

Chatterton³

et al. 2012

IJN

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show abstract

“…[26][27][28] It has been applied in controlling secondary structures of nanofibers, encapsulating drugs or biological agents into polymeric nanofibers, fabricating polymeric microtubes, preparing nanofibers from materials that lack filamentforming properties, and enclosing functional liquids within the fiber matrix. [29][30][31][32][33] Through modifications, nanofiber diameters can be manipulated for controlling the size of self-assembled nanoparticles, preparing ultrafine structures from concentrated polymer solutions, and improving nanofiber quality systematically. [34][35][36][37][38][39] Based on the above knowledge, we report on the formation of a novel solid dispersion in the form of coresheath nanofibers produced using a coaxial electrospinning process.…”

Section: Introductionmentioning

confidence: 99%

Solid dispersions in the form of electrospun core-sheath nanofibers

Yu¹,

Zhu²,

Branford-White³

et al. 2011

IJN

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Background:The objective of this investigation was to develop a new type of solid dispersion in the form of core-sheath nanofibers using coaxial electrospinning for poorly water-soluble drugs. Different functional ingredients can be placed in various parts of core-sheath nanofibers to improve synergistically the dissolution and permeation properties of encapsulated drugs and to enable drugs to exert their actions. Methods: Using acyclovir as a model drug, polyvinylpyrrolidone as the hydrophilic filamentforming polymer matrix, sodium dodecyl sulfate as a transmembrane enhancer, and sucralose as a sweetener, core-sheath nanofibers were successfully prepared, with the sheath part consisting of polyvinylpyrrolidone, sodium dodecyl sulfate, and sucralose, and the core part composed of polyvinylpyrrolidone and acyclovir. Results: The core-sheath nanofibers had an average diameter of 410 ± 94 nm with a uniform structure and smooth surface. Differential scanning calorimetry and x-ray diffraction results demonstrated that acyclovir, sodium dodecyl sulfate, and sucralose were well distributed in the polyvinylpyrrolidone matrix in an amorphous state due to favoring of second-order interactions. In vitro dissolution and permeation studies showed that the core-sheath nanofiber solid dispersions could rapidly release acyclovir within one minute, with an over six-fold increased permeation rate across the sublingual mucosa compared with that of crude acyclovir particles. Conclusion: The study reported here provides an example of the systematic design, preparation, characterization, and application of a novel type of solid dispersion consisting of multiple components and structural characteristics.

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“…Confocal fluorescence microscopy is one of the most commonly used imaging modalities to verify the core-shell structure of multilayered MPs [17,62,80]. Wang et al stained the BSA core with fluorescein isothiocyanate and stained the PLGA shell with rhodamine-B for confocal fluorescence microscopic imaging of IGF-1 loaded microspheres [62], as shown in Figure 7.…”

Section: Mps and Nps Fabricated By Coaxial Electrospraymentioning

confidence: 99%

Coaxial electrospray of microparticles and nanoparticles for biomedical applications

Zhang

Huang

et al. 2012

Expert Review of Medical Devices

177

111

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Coaxial electrospray is an electrohydrodynamic process that produces multilayer microparticles and nanoparticles by introducing coaxial electrified jets. In comparison with other microencapsulation/nanoencapsulation processes, coaxial electrospray has several potential advantages such as high encapsulation efficiency, effective protection of bioactivity and uniform size distribution. However, process control in coaxial electrospray is challenged by the multiphysical nature of the process and the complex interplay of multiple design, process and material parameters. This paper reviews the previous works and the recent advances in design, modeling and control of a coaxial electrospray process. The review intends to provide general guidance for coaxial electrospray and stimulate further research and development interests in this promising microencapsulation/nanoencapsulation process.

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One‐Step Immobilization of Protein‐Encapsulated Core/Shell Particles onto Nanofibers

Cited by 16 publications

References 56 publications

Polyacrylonitrile nanofibers coated with silver nanoparticles using a modified coaxial electrospinning process

Polyacrylonitrile nanofibers coated with silver nanoparticles using a modified coaxial electrospinning process

Solid dispersions in the form of electrospun core-sheath nanofibers

Coaxial electrospray of microparticles and nanoparticles for biomedical applications

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