One-pot synthesis of template-free hollow anisotropic CaCO₃ structures: towards inorganic shape-mimicking drug delivery systems

Abstract

A major obstacle in the introduction of nanoformulated drugs has been the fact that shape of the drug delivery systems (DDSs) - the most important parameter driven by nature for...

Magnetically Controlled Carbonate Nanocomposite with Ciprofloxacin for Biofilm Eradication

“…Embedding magnetite in the composite matrix solves two problems at once: the targeted delivery of an antibacterial agent and its controlled effect. At the same time, the release of active components from the matrix scaffold by external forced action occurs much faster than the effect of environmental changes in the pH through the bacteria's vital activity [46]. In addition to this, the mechanical effect exerted under the influence of an external magnetic field on the disintegration of the bacterial biofilm makes it possible to reduce the amount of the antibacterial component loaded into the matrix [47].…”

Nanomaterial Shape Influence on Cell Behavior

“…Over the last few years, the application of nanotechnology in biomedicine has become an alternative strategy for the treatment of disease, especially of microbial cell-mediated infection [ 136 ]. The nanoparticle platform has been used in drug delivery systems [ 10 , 137 ] and as part of implants coating against biofilms [ 138 , 139 ]. These examples expand the potential of synthetic and natural strategies to overcome antibiotic resistance and, consequently, serve as a universal approach for treating microbe-mediated disease.…”

“…The shape control of nanomaterials represents a major field in materials science, and a large number of approaches exist towards the production of sphere- [8], ellipsoid- [9], dumbbell- [10], cube- [11], polyhedra- [12], rod- [13], urchin- [14], star- [15], chain- [16], ribbon- [17], hollow [18], prism- [19], and hexagon-shaped [20] nanomaterials. Nanomaterial shape control stems from effects such as selective adsorption growth of reactive facets; spontaneous aggregation and agglomeration; seeded growth on particularly-shaped templates; controllable crystal fusion via orientation attachment; self-assembly via selective strong interactions, e.g., chemical and hydrogen bonds; and Ostwald ripening directed at free surface energy minimization.…”

Inverse Material Search and Synthesis Verification by Hand Drawings via Transfer Learning and Contour Detection

“…To validate the technology of inverse materials search, we decided to focus on two well-known systems. Calcium carbonate (CaCO 3 ) represents an inorganic material with a huge potential in the formation of complex micro-and macrostructures, [22,23] which is evident from its wide use by the living organisms in the process of biomineralization, [24][25][26] thereby it is widely used in drug delivery, [27][28][29][30][31][32][33] photonics, [34,35] etc. Gold nanomaterials, in turn, represent functional materials, which are widely used in drug delivery and photonics mainly due to surface plasmon resonance, [36] photothermal activity, [37][38][39] and surface chemistry tunability, [40] which, coupled with the ability of precise shape control, [41,42] makes it a promising nanomaterial for nanomedicine and physics.…”