One-pot synthesis of symmetrical and unsymmetrical acridine sulfonamide derivatives catalyzed by p-TSA

Maheswari, C.; Ramesh, Rathinam; Lalitha, Appaswami

doi:10.1007/s11164-017-2870-2

Cited by 14 publications

(10 citation statements)

References 21 publications

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“…prepared acridinedione benzenesulfonamides 34 using one‐pot multi‐component reaction of cyclic‐1,3‐diketones, sulphanilamide and different aldehydes using p ‐TSA as catalyst (Scheme 29). [69] Earlier, a similar reaction to form such derivatives has also been reported using iodine as catalyst [185] …”

Section: Synthesis Of Acridine‐18‐dione Derivativesmentioning

confidence: 85%

“…Various recyclable catalysts such as 1,3,5‐tris(2‐hydroxyethyl) isocyanurate covalently functionalized nano MCM‐41, [58] zeolite nanoparticles, [59] cobalt‐alanine metal complex, [60] deep eutectic solvent choline chloride:2ZnCl 2 , [61] Fe 3 O 4 @SiO 2 @Ni–Zn–Fe LDH magnetically mesoporous, [62] silica gel supported β ‐cyclodextrin/imidazolium based ionic liquid, [63] graphene‐based nanoparticles, [64] superparamagnetic Fe 3 O 4 @SiO 2 , [65] and USY‐zeolite., [66] have been used for the synthesis of acridine‐1,8‐diones. Recently, some metal‐free processes have also been developed for the synthesis of similar derivatives with good to excellent yields [67–69] . Some biological active 1,4‐dihydropyridines and acridine‐1,8‐diones are shown in figure 2.…”

Section: Introductionmentioning

confidence: 99%

“…Recently, some metal-free processes have also been developed for the synthesis of similar derivatives with good to excellent yields. [67][68][69] Some biological active 1,4-dihydropyridines and acridine-1,8diones are shown in figure 2.…”

Section: Introductionmentioning

confidence: 99%

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Application of Cyclohexane‐1,3‐diones in the Synthesis of Six‐Membered Nitrogen‐Containing Heterocycles

Sharma¹,

Kumar

et al. 2022

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Cyclohexane‐1,3‐dione and its derivatives are imperative precursors in synthetic organic chemistry as they are useful intermediates for the synthesis of a wide range of biologically active natural products, heterocycles and pharmaceuticals. Recently, cyclohexane‐1,3‐diones have been used for the synthesis of varied array of six‐membered nitrogen‐containing heterocycles in the presence of aldehydes, acetoacetic esters, malononitrile, chalcones, coumarins, acetophenones, amino acids, amines, etc. under catalytic and non‐catalytic conditions. Newest studies on the importance of these heterocycles motivated us to compile all the recently developed processes which include the fabrication of six‐membered nitrogen heterocycles. This article is mainly focused on the efficient synthesis of six‐membered N‐heterocycles i. e. 1,4‐dihydropyridine, acridine‐1,8‐diones, benzoacridinones, quinolones and pyridine derivatives from cyclohexane‐1,3‐diones as one of the substrates, published for the last ten years.

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Section: Synthesis Of Acridine‐18‐dione Derivativesmentioning

confidence: 85%

Section: Introductionmentioning

confidence: 99%

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Application of Cyclohexane‐1,3‐diones in the Synthesis of Six‐Membered Nitrogen‐Containing Heterocycles

Sharma¹,

Kumar

et al. 2022

ChemistrySelect

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“…Maheswari and colleagues [76] discovered Hantzsch multicomponent reaction using PTSA as a catalyst, CH 3 CN as a solvent to get good yields of ADD in less reaction time via avoiding long purification. The effect of different catalysts such as CAN, bismuth nitrate, oxalic acid, HCl, H 2 SO 4 , HNO 3 etc.…”

Section: Synthesis Of Acridine‐18‐dione Derivativesmentioning

confidence: 99%

“…Maheswari and colleagues [76] discovered Hantzsch multicomponent reaction using PTSA as a catalyst, CH 3 A facile and economical KH 2 PO 4 catalyzed one-pot MCR of various aldehydes, 1,3-dicarbonyls and ammonium acetate in aqueous ethanol to produce acridine-1,8-dione in high yields was demonstrated by Yu et al. [77] KH 2 PO 4 is an inorganic salt and works as an eco-friendly, low-cost, less-toxic catalyst [Scheme 9, Method 4].…”

Section: Acid Catalyzed Synthesismentioning

confidence: 99%

Acridine‐1,8‐diones: Synthesis and Biological Applications

Sahiba¹,

Sethiya²,

Soni³

et al. 2021

ChemistrySelect

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The unpretentious features of acridine‐1,8‐diones viz. presence of N‐heteroatom, electronic behavior, acridine ring skeleton and wide possibilities of diversified substitution, bichromophoric structure and interaction ability with various proteins, make them an interesting scaffold of heterocyclic, medicinal and industrial chemistry. A tremendous development in the field of acridinediones in terms of synthetic strategies, bioactivity, industrial and other applicability has been explored in past four decades. In this perspective, an overview has been given on the state‐of‐art discoveries for the synthesis and biological applications of acridine‐1,8‐diones from 1980 to 2020. The study highlighted the history, chemistry and properties of these derivatives and provided deep insights into the synthetic protocols using various catalysts and techniques like nano‐catalyst, ionic‐liquids, microwave, ultrasound etc. under varied conditions along with biological activity against many lethal diseases. Finally, the respective prospects and limitations to these systems have been addressed. Furthermore, attempts have been done to bring many outstanding researches together and express the significance of acridine‐1,8‐diones through several aspects. We hope that the article shall deliver an impetus to explore further the synthetic values and mechanistic puzzles of acridinedione moiety and to design more promising hybrid multi‐targeted drugs and other industrial composites for the goodness of humanity

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A rapid and green method for expedient multicomponent synthesis of N-substituted decahydroacridine-1,8-diones as potential antimicrobial agents

et al. 2018

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One-pot synthesis of symmetrical and unsymmetrical acridine sulfonamide derivatives catalyzed by p-TSA

Cited by 14 publications

References 21 publications

Application of Cyclohexane‐1,3‐diones in the Synthesis of Six‐Membered Nitrogen‐Containing Heterocycles

Application of Cyclohexane‐1,3‐diones in the Synthesis of Six‐Membered Nitrogen‐Containing Heterocycles

Acridine‐1,8‐diones: Synthesis and Biological Applications

A rapid and green method for expedient multicomponent synthesis of N-substituted decahydroacridine-1,8-diones as potential antimicrobial agents

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