One-Pot Synthesis of Imidazolidine-2-Thiones, Hydantoins and Thiohydantoins under Solvent-Free and Grinding Conditions

Abstract

A convenient, environmentally friendly and mild green synthesis of imidazolidine-2-thiones, hydantoin and thiohydantoin derivatives was developed by the one-pot reaction of benzils, urea or thiourea derivatives, and strong base at with grinding. The key advantages are the short reaction times, excellent yields, simple workup, and easy purification in the solvent-free condition. The present method aimed to overcome the limitations and drawbacks of the reported methods such as hard work-up, low yield, hazardous solvent and long reaction time.

One-Pot Synthesis, Pharmacological Evaluation, Docking Study, and DFT Calculations for Selected Imidazolidine-2,4-Diones

“…The imidazolidine-2,4-dione (hydantoin) is a common 5membered ring containing a reactive cyclic used in medicinal chemistry because of its broad spectrum of biological activity. They have a number of biological activities as antiarrhythmic, anti-inflammatory, antitumor, and antidiabetic properties, in addition to the herbicidal and fungicidal activity (Cheng et al, 2008;Colacino et al, 2007;Ghanbari et al, 2014;Katritzky et al, 1998;Nefzi et al, 2000). There were a number of methods have been reported for the synthesis of 5-substituted analogs of hydantoins including multi-step methods, one-pot, solid-phase and microwaveassisted.…”