Microwave synthesis of 2,3,5-trisubstituted-1,3-imidazolidin-4-ones bearing 1,3,4-oxadiazole moiety and preliminary evaluation of their antibacterial activity

Abood, Zeid Hassan; Ali, Hayder Raheem; Qabel, Hussein Ali

doi:10.1063/1.5123064

Cited by 1 publication

(1 citation statement)

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“…Abood et al. (2019) synthesized 5‐(4‐aminophenyl)‐1,3,4‐oxadiazole‐2‐thiol 88 , when 4‐aminobenzohydrazide 87 reacts with carbon disulphide in the presence of potassium hydroxide act as a reducing agent in which ethanol (solvent) to gives a final product 88 . This reaction takes 24 h at 70°C to complete with 75% yield (Scheme 23).…”

Section: Strategies For the Synthesis Of 134‐oxadiazole And Its Deriv...mentioning

confidence: 99%

Substrate‐based synthetic strategies and biological activities of 1,3,4‐oxadiazole: A review

Sharma,

Kumar,

Mazumder

et al. 2024

Chem Biol Drug Des

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The five‐membered 1,3,4‐oxadiazole heterocyclic ring has received considerable attention because of its unique bio‐isosteric properties and an unusually wide spectrum of biological activities. After a century since 1,3,4‐oxadiazole was discovered, its uncommon potential attracted medicinal chemist's attention, leading to the discovery of a few presently accessible drugs containing 1,3,4‐oxadiazole units, and a large number of patents have been granted on research related to 1,3,4‐oxadiazole. It is worth noting that interest in 1,3,4‐oxadiazoles' biological applications has doubled in the last few years. Herein, this review presents a comprehensive overview of the recent achievements in the synthesis of 1,3,4‐oxadiazole‐based compounds and highlights the major advances in their biological applications in the last 10 years, as well as brief remarks on prospects for further development. We hope that researchers across the scientific streams will benefit from the presented review articles for designing their work related to 1,3,4‐oxadiazoles.

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Section: Strategies For the Synthesis Of 134‐oxadiazole And Its Deriv...mentioning

confidence: 99%

Substrate‐based synthetic strategies and biological activities of 1,3,4‐oxadiazole: A review

Sharma,

Kumar,

Mazumder

et al. 2024

Chem Biol Drug Des

View full text Add to dashboard Cite

show abstract

Microwave synthesis of 2,3,5-trisubstituted-1,3-imidazolidin-4-ones bearing 1,3,4-oxadiazole moiety and preliminary evaluation of their antibacterial activity

Cited by 1 publication

References 20 publications

Substrate‐based synthetic strategies and biological activities of 1,3,4‐oxadiazole: A review

Substrate‐based synthetic strategies and biological activities of 1,3,4‐oxadiazole: A review

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