One‐Pot Synthesis of Carboxyl‐Functionalized Rare Earth Fluoride Nanocrystals with Monodispersity, Ultrasmall Size and Very Bright Luminescence

Wu, Xuejin; Zhang, Qingbin; Wang, Xin; Yang, Hui; Zhu, Y.

doi:10.1002/ejic.201001149

Cited by 20 publications

(11 citation statements)

References 23 publications

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“…These values are in good correspondence to the relatively long lifetimes of lanthanide-doped inorganic phosphors (Omkaram et al 2008; Grzyb et al 2012). An explanation of the slight increase in lifetime of the core/shell-type product can be a protective effect of the external thin layer of the silica shell, which decreases the quenching of the excited states of Tb 3+ ions by O–H oscillators of water molecules (Wu et al 2011). …”

Section: Resultsmentioning

confidence: 99%

Core/shell-type nanorods of Tb3+-doped LaPO4, modified with amine groups, revealing reduced cytotoxicity

et al. 2013

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A simple co-precipitation reaction between Ln3+ cations (Ln = lanthanide) and phosphate ions in the presence of polyethylene glycol (PEG), including post-treatment under hydrothermal conditions, leads to the formation of Tb3+-doped LaPO4 crystalline nanorods. The nanoparticles obtained can be successfully coated with amorphous and porous silica, forming core/shell-type nanorods. Both products reveal intensive green luminescence under UV lamp irradiation. The surface of the core/shell-type product can also be modified with –NH2 groups via silylation procedure, using 3-aminopropyltriethoxysilane as a modifier. Powder X-ray diffraction, transmission electron microscopy, and scanning electron microscopy confirm the desired structure and needle-like shape of the products synthesized. Fourier transform infrared spectroscopy and specific surface area measurements by Brunauer–Emmett–Teller method reveal a successful surface modification with amine groups of the core/shell-type nanoparticles prepared. The nanomaterials synthesized exhibit green luminescence characteristic of Tb3+ ions, as solid powders and aqueous colloids, examined by spectrofluorometry. The in vitro cytotoxicity studies reveal different degree toxicity of the products. LaPO4:Tb3+@SiO2@NH2 exhibits the smallest toxicity against B16F0 mouse melanoma cancer cells and human skin microvascular endothelial cell lines, in contrast to the most toxic LaPO4:Tb3+@SiO2.Graphical Abstract

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Section: Resultsmentioning

confidence: 99%

Core/shell-type nanorods of Tb3+-doped LaPO4, modified with amine groups, revealing reduced cytotoxicity

et al. 2013

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“…Such a unique property gives them several advantages in bioimaging, including remarkable penetration depth into tissues upon NIR excitation [28], significantly decreased autofluorescence [29], no photobleaching or photoblinking, and high spatial resolution during bioimaging [30,31]. In addition to photon up-conversion, these nanoparticles or microparticles simultaneously possess the capability of photon down-conversion [32], giving them dual excitation characteristics under an excitation source having both UV and NIR light.…”

Section: Discussionmentioning

confidence: 99%

Enhancement of Cerenkov Luminescence Imaging by Dual Excitation of Er3+, Yb3+-Doped Rare-Earth Microparticles

Kang

et al. 2013

PLoS ONE

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Cerenkov luminescence imaging (CLI) has been successfully utilized in various fields of preclinical studies; however, CLI is challenging due to its weak luminescent intensity and insufficient penetration capability. Here, we report the design and synthesis of a type of rare-earth microparticles (REMPs), which can be dually excited by Cerenkov luminescence (CL) resulting from the decay of radionuclides to enhance CLI in terms of intensity and penetration. Methods: Yb3+- and Er3+- codoped hexagonal NaYF4 hollow microtubes were synthesized via a hydrothermal route. The phase, morphology, and emission spectrum were confirmed for these REMPs by power X-ray diffraction (XRD), scanning electron microscopy (SEM), and spectrophotometry, respectively. A commercial CCD camera equipped with a series of optical filters was employed to quantify the intensity and spectrum of CLI from radionuclides. The enhancement of penetration was investigated by imaging studies of nylon phantoms and nude mouse pseudotumor models. Results: the REMPs could be dually excited by CL at the wavelengths of 520 and 980 nm, and the emission peaks overlaid at 660 nm. This strategy approximately doubled the overall detectable intensity of CLI and extended its maximum penetration in nylon phantoms from 5 to 15 mm. The penetration study in living animals yielded similar results. Conclusions: this study demonstrated that CL can dually excite REMPs and that the overlaid emissions in the range of 660 nm could significantly enhance the penetration and intensity of CL. The proposed enhanced CLI strategy may have promising applications in the future.

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“…29,33 The strong peak at 1728 cm À1 is assigned to the C]O asymmetric vibration of the free carboxyl groups of PAAs which improve the hydrophilicity of the as-obtained NaGdF 4 :Yb 3+ /Er 3+ nanoparticles. 29,34 Thermogravimetric analysis was used to assess the amount of capped ligands on the surface of the as-prepared NaGdF 4 :-Yb 3+ /Er 3+ nanoparticles. Fig.…”

Section: Resultsmentioning

confidence: 99%

Dual-modal imaging and excellent anticancer efficiency of cisplatin and doxorubicin loaded NaGdF₄:Yb³⁺/Er³⁺ nanoparticles

et al. 2018

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One‐Pot Synthesis of Carboxyl‐Functionalized Rare Earth Fluoride Nanocrystals with Monodispersity, Ultrasmall Size and Very Bright Luminescence

Cited by 20 publications

References 23 publications

Core/shell-type nanorods of Tb3+-doped LaPO4, modified with amine groups, revealing reduced cytotoxicity

Core/shell-type nanorods of Tb3+-doped LaPO4, modified with amine groups, revealing reduced cytotoxicity

Enhancement of Cerenkov Luminescence Imaging by Dual Excitation of Er3+, Yb3+-Doped Rare-Earth Microparticles

Dual-modal imaging and excellent anticancer efficiency of cisplatin and doxorubicin loaded NaGdF₄:Yb³⁺/Er³⁺ nanoparticles

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One‐Pot Synthesis of Carboxyl‐Functionalized Rare Earth Fluoride Nanocrystals with Monodispersity, Ultrasmall Size and Very Bright Luminescence

Cited by 20 publications

References 23 publications

Core/shell-type nanorods of Tb3+-doped LaPO4, modified with amine groups, revealing reduced cytotoxicity

Core/shell-type nanorods of Tb3+-doped LaPO4, modified with amine groups, revealing reduced cytotoxicity

Enhancement of Cerenkov Luminescence Imaging by Dual Excitation of Er3+, Yb3+-Doped Rare-Earth Microparticles

Dual-modal imaging and excellent anticancer efficiency of cisplatin and doxorubicin loaded NaGdF4:Yb3+/Er3+ nanoparticles

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Dual-modal imaging and excellent anticancer efficiency of cisplatin and doxorubicin loaded NaGdF₄:Yb³⁺/Er³⁺ nanoparticles