Dual-modal imaging and excellent anticancer efficiency of cisplatin and doxorubicin loaded NaGdF4:Yb3+/Er3+ nanoparticles

Zhang, Zhiyang; Sheng, Jian‐Zhong; Zhang, Miaomiao; Ma, Xiaoyan; Geng, Zhirong; Wang, Zhilin

doi:10.1039/c8ra03898h

Cited by 7 publications

(3 citation statements)

References 48 publications

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“…Phosphor materials have a significant role in our daily life as they possess widespread applications ranging from solid-state lighting, colorful displays, and solar cells − to anti-counterfeiting inks, − photodynamic therapy, biomedical imaging, − etc. Globally, a significant portion of phosphors is utilized for developing white light-emitting diodes (WLEDs) for general lighting purposes.…”

Section: Introductionmentioning

confidence: 99%

ZnAl₂O₄:Eu³⁺ Nanoparticle Phosphors Co-doped with Li⁺ for Red Light-Emitting Diodes

Samanta

Dey

et al. 2021

ACS Appl. Nano Mater.

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In recent years, rare-earth doped phosphors have gathered immense attention in the luminescence field for lighting and electronic display applications. However, the unavailability of an efficient and low-cost red phosphor is a major challenge for the widespread deployment of white light-emitting diodes (WLEDs) for practical purposes. Here we report red light-emitting Li+ co-doped ZnAl2O4:Eu3+ nanophosphors synthesized by a modified sol–gel route. These nanophosphors show excellent red emission due to the 5D0 → 7F j (j = 1, 2, 3, and 4) transition of Eu3+ ions under 394 nm excitation. Li+ co-doped ZnAl2O4:Eu3+ nanophosphors exhibit an almost 2-fold increase in photoluminescence (PL) intensity upon incorporation of the optimum amount of Li+ in the ZnAl2O4:Eu3+ matrix. Apart from that, Li+ co-doping leads to the improvement of CIE coordinates that is also reflected from the enhanced color purity offered by the co-doped nanophosphors. Steady-state as well as time-resolved PL spectra clearly reveal that addition of Li+ co-activator successfully reduces nonradiative transitions in the co-doped nanophosphors. Introduction of Li+ in Eu3+ doped ZnAl2O4 effectively neutralizes the charge imbalance problem and thus leads to a significant increase in the PL efficiency of the nanophosphors. The red LED fabricated by those co-doped nanophosphors exhibits strong red emission under a driving voltage of 3 V. Obtained results strongly highlight the bright prospect of Li+ co-doped ZnAl2O4:Eu3+ nanophosphors in the LED and display applications.

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Section: Introductionmentioning

confidence: 99%

ZnAl₂O₄:Eu³⁺ Nanoparticle Phosphors Co-doped with Li⁺ for Red Light-Emitting Diodes

Samanta

Dey

et al. 2021

ACS Appl. Nano Mater.

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“…The burst release at pH 5 during the initial stage (to 8 h) may be due to the weakened coordination bonding between the CPPD and PLGA in the acidic solution [ 54 ]. Alternatively, a reduced electrostatic interaction or hydrogen bonding between –NH 3 in CDDP and –COOH/–OH in PLGA from H + may also exist [ 55 , 56 ]. At the later stage (from 8 to 72 h), the drug release rate at pH 5 is still higher than at pH 7.4, which may be owing to the fast degradation of the PLGA in an acidic environment, which induces the sustained release of the CDDP [ 57 ].…”

Section: Resultsmentioning

confidence: 99%

Hyaluronic Acid-Modified Cisplatin-Encapsulated Poly(Lactic-co-Glycolic Acid) Magnetic Nanoparticles for Dual-Targeted NIR-Responsive Chemo-Photothermal Combination Cancer Therapy

Chen

Dash

et al. 2023

Pharmaceutics

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Combination chemo-photothermal therapy with nanomaterials can reduce the dose of chemotherapeutic drugs required for effective cancer treatment by minimizing toxic side effects while improving survival times. Toward this end, we prepare hyaluronic acid (HA)-modified poly(lactic-co-glycolic acid) (PLGA) magnetic nanoparticles (MNP) for the CD44 receptor-mediated and magnetic field-guided dual-targeted delivery of cisplatin (CDDP). By co-encapsulating the CDDP and oleic acid-coated iron oxide MNP (IOMNP) in PLGA, the PMNPc was first prepared in a single emulsification/solvent evaporation step and successively surface modified with chitosan and HA to prepare the HA/PMNPc. Spherical HA/PMNPc nanoparticles of ~300 nm diameter can be prepared with 18 and 10% (w/w) loading content of CDDP and IOMNP and a pH-sensitive drug release to facilitate the endosomal release of the CDDP after intracellular uptake. This leads to the higher cytotoxicity of the HA/PMNPc toward the U87 glioblastoma cells than free CDDP with reduced IC50, a higher cell apoptosis rate, and the enhanced expression of cell apoptosis marker proteins. Furthermore, the nanoparticles show the hyperthermia effect toward U87 after short-term near-infrared (NIR) light exposure, which can further elevate the cell apoptosis/necrosis rate and upregulate the HSP70 protein expression due to the photothermal effects. The combined cancer therapeutic efficacy was studied in vivo using subcutaneously implanted U87 cells in nude mice. By using dual-targeted chemo-photothermal combination cancer therapy, the intravenously injected HA/PMNPc under magnetic field guidance and followed by NIR laser irradiation was demonstrated to be the most effective treatment modality by inhibiting the tumor growth and prolonging the survival time of the tumor-bearing nude mice.

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“…The TEM and FTIR were performed for the characterization of nanoparticles. These loaded NPs could be used for imaging, as well as for the codelivery of cisplatin and doxorubicin to improve the efficacy and inhibition effect of the tumour [111].…”

Section: Calcium-based Nanoparticlesmentioning

confidence: 99%

Recent progress in nanotechnology-based novel drug delivery systems in designing of cisplatin for cancer therapy: an overview

Farooq

Aquib

Farooq

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

107

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2019) Recent progress in nanotechnology-based novel drug delivery systems in designing of cisplatin for cancer therapy: an overview, Artificial ABSTRACT Cisplatin cis-(diammine)dichloridoplatinum(II) (CDDP) is the first platinum-based complex approved by the food and drug administration (FDA) of the United States (US). Cisplatin is the first line chemotherapeutic agent used alone or combined with radiations or other anti-cancer agents for a broad range of cancers such as lung, head and neck. Aroplatin TM , Lipoplatin TM and SPI-077 are PEGylated liposomebased nano-formulations that are still under clinical trials. They have many limitations, for example, poor aqueous solubility, drug resistance and toxicities, which can be overcome by encapsulating the cisplatin in Nemours nanocarriers. The extensive literature from different electronic databases covers the different nano-delivery systems that are developed for cisplatin. This review critically emphasizes on the recent advancement, development, innovations and updated literature reported for different carrier systems for CDDP. ARTICLE HISTORY Current status of FDA-approved/under clinical trials CDDP nano-formulationsMany liposomal-based nano-formulations are at the stage of clinical trials. One of under clinical trials drugs, Lipoplatin (Regulon, Inc.), is liposome-based platinum formulation under Phase III clinical trials [11]. It contains a combination of cisplatin (9%) and lipids (91%(w/w)), including soy phosphatidylcholine (SPC-3), cholesterol, dipalmitoyl phosphatidyl glycerol (DPPG) and methoxy-PEG-distearoyl phosphatidyl

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Dual-modal imaging and excellent anticancer efficiency of cisplatin and doxorubicin loaded NaGdF₄:Yb³⁺/Er³⁺ nanoparticles

Abstract: The drug delivery system NaGdF4–CDDP–DOX showed best tumor inhibition capacity both in vitro and in vivo.

Cited by 7 publications

References 48 publications

ZnAl₂O₄:Eu³⁺ Nanoparticle Phosphors Co-doped with Li⁺ for Red Light-Emitting Diodes

ZnAl₂O₄:Eu³⁺ Nanoparticle Phosphors Co-doped with Li⁺ for Red Light-Emitting Diodes

Hyaluronic Acid-Modified Cisplatin-Encapsulated Poly(Lactic-co-Glycolic Acid) Magnetic Nanoparticles for Dual-Targeted NIR-Responsive Chemo-Photothermal Combination Cancer Therapy

Recent progress in nanotechnology-based novel drug delivery systems in designing of cisplatin for cancer therapy: an overview

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Dual-modal imaging and excellent anticancer efficiency of cisplatin and doxorubicin loaded NaGdF4:Yb3+/Er3+ nanoparticles

Abstract: The drug delivery system NaGdF4–CDDP–DOX showed best tumor inhibition capacity both in vitro and in vivo.

Cited by 7 publications

References 48 publications

ZnAl2O4:Eu3+ Nanoparticle Phosphors Co-doped with Li+ for Red Light-Emitting Diodes

ZnAl2O4:Eu3+ Nanoparticle Phosphors Co-doped with Li+ for Red Light-Emitting Diodes

Hyaluronic Acid-Modified Cisplatin-Encapsulated Poly(Lactic-co-Glycolic Acid) Magnetic Nanoparticles for Dual-Targeted NIR-Responsive Chemo-Photothermal Combination Cancer Therapy

Recent progress in nanotechnology-based novel drug delivery systems in designing of cisplatin for cancer therapy: an overview

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Dual-modal imaging and excellent anticancer efficiency of cisplatin and doxorubicin loaded NaGdF₄:Yb³⁺/Er³⁺ nanoparticles

ZnAl₂O₄:Eu³⁺ Nanoparticle Phosphors Co-doped with Li⁺ for Red Light-Emitting Diodes

ZnAl₂O₄:Eu³⁺ Nanoparticle Phosphors Co-doped with Li⁺ for Red Light-Emitting Diodes