One-pot synthesis and characterization of crosslinked polyphosphazene dopamine microspheres for controlled drug delivery applications

Örüm, Simge Metinoğlu; Demircioğlu, Yasemin Süzen

doi:10.1080/10601325.2019.1615838

Cited by 21 publications

(4 citation statements)

References 35 publications

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“…One-pot synthesis of crosslinked POPs dopamine microspheres for controlled drug delivery has been reported by reacting in acetonitrile HCCP, triethylamine, and dopamine at 50 °C for 3 h under ultrasonic irradiation (53 kHz, 150 W). Cyclomatrix polyphosphazene microspheres have been achieved which are able to absorb acriflavine (19.5 mg acriflavine/gram of microsphere), as a model drug, and which release the drug for a long time depending on the pH (29% released in acidic medium; 47% at neutral pH) for up to 7 days [ 157 ]. A new class of tripodal amphiphiles for self-assembly to bilayered polymersomes, based on cyclotriphosphazenes bearing equimolar amounts of hydrophilic polyethylene glycol and a hydrophobic oligopeptide, have been proposed, for which the shape (micelles or polymersomes) resulted depended on the hydrophobicity of the oligopeptide [ 158 ].…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Cyclo- and Polyphosphazenes for Biomedical Applications

et al. 2022

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Cyclic and polyphosphazenes are extremely interesting and versatile substrates characterized by the presence of -P=N- repeating units. The chlorine atoms on the P atoms in the starting materials can be easily substituted with a variety of organic substituents, thus giving rise to a huge number of new materials for industrial applications. Their properties can be designed considering the number of repetitive units and the nature of the substituent groups, opening up to a number of peculiar properties, including the ability to give rise to supramolecular arrangements. We focused our attention on the extensive scientific literature concerning their biomedical applications: as antimicrobial agents in drug delivery, as immunoadjuvants in tissue engineering, in innovative anticancer therapies, and treatments for cardiovascular diseases. The promising perspectives for their biomedical use rise from the opportunity to combine the benefits of the inorganic backbone and the wide variety of organic side groups that can lead to the formation of nanoparticles, polymersomes, or scaffolds for cell proliferation. In this review, some aspects of the preparation of phosphazene-based systems and their characterization, together with some of the most relevant chemical strategies to obtain biomaterials, have been described.

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Section: Biomedical Applicationsmentioning

confidence: 99%

Cyclo- and Polyphosphazenes for Biomedical Applications

et al. 2022

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“…22 Various non-halogen flame retardants and high-temperature resistant materials can be developed using HCCP as an ingredient. [23][24][25][26][27] For instance, hexamethallylalcoholcyclotriphosphazene (HMACP) and hexaeugenolcyclotriphosphazene (HECP) were synthesized and mixed with bismaleimide resin to reduce heat and smoke emission while increasing impact strength. 28 Benzimidazolylsubstituted cyclotriphosphazene (BICP) was synthesized from phosphazene and benzimidazole and added to EP, the EPbased composites performed excellent flame retardancy, but mechanical properties were slightly damaged.…”

Section: Introductionmentioning

confidence: 99%

Fire retardant polyethylene terephthalate containing 4,4′-(hexafluoroisopropylidene)diphenol-substituted cyclotriphosphazene microspheres

Sun

Zhu

et al. 2022

High Performance Polymers

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Polyphosphazene derivatives are gaining popularity due to their eco-friendly character and high content of flame-retardant components. Herein, a polyphosphazene derivative (PZAF) microsphere was successfully synthesized utilizing an in-situ template approach, which was then employed as an additive flame retardant in polyethylene terephthalate (PET) to improve the fire safety. Thermogravimetric analysis revealed that PZAF promoted the pyrolysis of PET in advance to generate a stable char layer that protects the matrix from heat, consequently increasing char residues. With addition of 10 wt% PZAF, the PET nanocomposites obtained a V-0 grade in vertical combustion test and its LOI value increased from 24.2 vol% to 32.1 vol%. Moreover, the peak heat release and carbon monoxide production decreased by 46.6% and 50.6%, respectively. This was because the phosphonic acid fragments and pyridine ring compounds produced by the PZAF pyrolysis encouraged the development of a robust char layer. Meanwhile, the •PO radicals generated by the pyrolysis of PZAF could capture free radicals in the gas phase, ultimately ending the chain reaction of combustion. Also, mechanical properties of the PET nanocomposites were noticeably enhanced by the addition of 3 or 5 wt% PZAF.

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“…Moreover, it can be noted that the multiple PCl active reaction sites make it possible to achieve polymerization reaction with various nucleophilic reagents 14,15 . Therefore, a large number of nano or micro‐sized materials including microspheres, 16,17 sub‐microtubes, 18 nanospheres, 19 nanofibers 20,21 could be facilely synthesized by the simple polymerization of HCCP and other compounds. These materials are commonly used in various sectors, such as adsorption, 22,23 photochemical catalysis, 24 conductivity, 25 and flame retardency 26 .…”

Section: Introductionmentioning

confidence: 99%

Synthesis and application of poly (cyclotriphosphazene‐resveratrol) microspheres for enhancing flame retardancy of poly (ethylene terephthalate)

Zhu

Wang

et al. 2021

Polymers for Advanced Techs

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A poly (cyclotriphosphazene-resveratrol) (PRS) microsphere was synthesized via a feasible in-situ template approach and applied to poly (ethylene terephthalate) (PET) for ameliorating its flammable and melt-dropping issues. The prepared PRS microspheres displayed superior thermal stability and flame retardancy. By incorporating only 2 wt% of PRS microspheres into PET matrix, the limiting oxygen index value was increased from 23.3% to 28.3% and reached the UL-94 V-0 level without any afterflame time. Cone calorimeter test demonstrated that the HRR and THR of PET/FR2.0 composite decreased significantly by 31.1% and 13.5%, respectively, which remarkably increased the fire safety of PET. On the other hand, the tensile strength and elongation at break of PET/FR2.0 composite decreased slightly, whereas the tensile modulus was increased by 10.5% than that of the pure PET. Moreover, the fireretardant mechanism of PRS microspheres was fully investigated, revealing that PET/FR system would generate compact and continuous char layers rapidly during combustion, the underlay materials would not be further cracked due to the isolation of external heat and oxygen. Nonflammable gases such as ammonia were also released to dilute the concentration of combustible gases around the PET matrix, achieving an efficient flame retardant effect.

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One-pot synthesis and characterization of crosslinked polyphosphazene dopamine microspheres for controlled drug delivery applications

Cited by 21 publications

References 35 publications

Cyclo- and Polyphosphazenes for Biomedical Applications

Cyclo- and Polyphosphazenes for Biomedical Applications

Fire retardant polyethylene terephthalate containing 4,4′-(hexafluoroisopropylidene)diphenol-substituted cyclotriphosphazene microspheres

Synthesis and application of poly (cyclotriphosphazene‐resveratrol) microspheres for enhancing flame retardancy of poly (ethylene terephthalate)

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