On the significance of brain extracellular uric acid detected with in-vivo monitoring techniques: a review

Characterization of permselective coatings electrosynthesized on Pt–Ir from the three phenylenediamine isomers for biosensor applications

“…Even for monitoring body glucose concentration in peripheral tissues such as subcutaneous fat, small needle or fiber-type electrodes are desirable [65][66][67]. For measurements in discrete brain regions, these factors are critical [16,68,69], and the range of applications involving biosensors based on Teflon ® -coated Pt wire illustrates the success of this design for brain glucose monitoring [21,[70][71][72][73][74]. Recently, we have demonstrated that substituting the more rigid Pt-Ir for pure Pt provides more robust biosensors with comparable analyte sensitivity [20].…”

Detecting Subsecond Dopamine Release with Fast-Scan Cyclic Voltammetry in Vivo

“…Some researchers implant an electrode during surgery and use it for all subsequent experimental measurements. However, as demonstrated in the calibration experiments, electrodes lose some sensitivity and have a slower time response after implantation in the brain (40 ). Gliosis can also occur around the electrode after long time periods.…”

“…These findings are useful in interpreting the role of dopamine in ICS, suggesting that it is more important in acquisition than maintenance of the behavior. [Note that Kruk et al (57 ), also using fast-scan cyclic voltammetry, failed to detect dopamine release even in the acquisition phase of intracranial self-stimulation; however, this may be attributable to the use of chronically implanted electrodes, which are less sensitive than acutely implanted ones (40 ). ]…”

Effects of polymerization potential on the permselectivity of poly(o-phenylenediamine) coatings deposited on Pt–Ir electrodes for biosensor applications

“…Important design features in this context include the size and geometry of the sensor, which have relevance to both the efficient interrogation of the surrounding cells and minimization of tissue damage [4][5][6][7]. Even for monitoring body glucose concentration in peripheral tissues such as subcutaneous fat, small needle or fibre-type electrodes are desirable [8][9][10], and for measurements in discrete brain regions these factors are even more crucial [11][12][13]. The range of applications involving amperometric biosensors based on Teflon-coated Pt or Pt-Ir wire cylinder electrodes illustrate the success of this design for brain glucose monitoring in brain structures, such as rat dorsal striatum [14][15][16][17][18][19].…”