On the Extraction of Antibiotics from Shrimps Prior to Chromatographic Analysis

Samanidou, Victoria; Bitas, Dimitrios; Charitonos, Stamatia; Papadoyannis, Ioannis N.

doi:10.3390/chromatography3010008

Cited by 13 publications

(8 citation statements)

References 73 publications

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“…The maximum residue limit in milk according to the Commission Regulation (EU) No. 37/2010 is 100 μg/kg for the sum of enrofloxacin (ENR) and ciprofloxacin (CIP), 30 μg/kg for danofloxacin (DAN), while difloxacin (DIF) and FFC are not recommended for milk producing animals [ 1 , 2 , 3 ].…”

Section: Mip Applications For the Extraction Of Antibiotics In Milmentioning

confidence: 99%

“…The maximum residue limit in milk according to the Commission Regulation (EU) No. 37/2010 is 100 μg/kg for cephalexin (CFL), 60 μg/kg for cephapirin (CFP), 50 μg/kg for cefazolin (CFZ) and 20 μg/kg for QUI [ 1 , 2 , 3 ].…”

Section: Mip Applications For the Extraction Of Antibiotics In Milmentioning

confidence: 99%

“…For this reason, the European Union has published the “Commission Regulation (EU) No. 37/2010 of 22 December 2009 on pharmacologically active substances and their classification regarding maximum residue limits in foodstuffs of animal origin” and every animal originated product should comply with [ 1 , 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

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Molecularly Imprinted Polymers as Extracting Media for the Chromatographic Determination of Antibiotics in Milk

Bitas

Samanidou

2018

Molecules

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Milk-producing animals are typically kept stationary in overcrowded large-scale farms and in most cases under unsanitary conditions, which promotes the development of infections. In order to maintain sufficient health status among the herd or promote growth and increase production, farmers administer preventative antibiotic doses to the animals through their feed. However, many antibiotics used in cattle farms are intended for the treatment of bacterial infections in humans. This results in the development of antibiotic-resistant bacteria which pose a great risk for public health. Additionally, antibiotic residues are found in milk and dairy products, with potential toxic effects for the consumers. Hence the need of antibiotic residues monitoring in milk arises. Analytical methods were developed for the determination of antibiotics in milk, with key priority given to the analyte extraction and preconcentration step. Extraction can benefit from the production of molecularly imprinted polymers (MIPs) that can be applied as sorbents for the extraction of specific antibiotics. This review focuses on the principals of molecular imprinting technology and synthesis methods of MIPs, as well as the application of MIPs and MIPs composites for the chromatographic determination of various antibiotic categories in milk found in the recent literature.

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Section: Mip Applications For the Extraction Of Antibiotics In Milmentioning

confidence: 99%

Section: Mip Applications For the Extraction Of Antibiotics In Milmentioning

confidence: 99%

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Molecularly Imprinted Polymers as Extracting Media for the Chromatographic Determination of Antibiotics in Milk

Bitas

Samanidou

2018

Molecules

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“…Additionally, online SPE , molecularly imprinted polymers (MIPS) and immobilized metal affinity columns with Fe 3+ were reported as alternatives to the conventional SPE mode and sorbents. All the above information, along with information about other antibiotic categories, has been recently published in a review on the extraction of antibiotics from shrimps before chromatographic analysis .…”

Section: Introductionmentioning

confidence: 99%

Effective cleanup for the determination of six quinolone residues in shrimp before HPLC with diode array detection in compliance with the European Union Decision 2002/657/EC

Bitas

Samanidou

2016

J of Separation Science

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A high-performance liquid chromatographic method was developed for the determination of six quinolone residues (ciprofloxacin, enrofloxacin, sarafloxacin, oxolinic acid, nalidixic acid, and flumequine) in shrimp tissue samples. Separation was carried out by a LiChrospher® 100 RP-8e column, running at a 22 min gradient elution program, and the mobile phase consisted of citric acid (0.4 mol/L), acetonitrile and methanol. Detection was achieved by a diode array detector, monitoring at 255 and 275 nm. Sample preparation included initial extraction with citric acid solution and further clean-up by solid-phase extraction, employing Lichrolut RP-18 cartridges. Validation was performed according to the European Union Decision 2002/657/EC. The detection capability was 127.2 μg/kg for ciprofloxacin, 115.2 μg/kg for enrofloxacin, 126.2 μg/kg for sarafloxacin, 113.1 μg/kg for oxolinic acid, 125.2 μg/kg for nalidixic acid, and 239.0 μg/kg for flumequine. Recoveries ranged between 83.0 and 121.6%. The Youden test was applied to study the method ruggedness.

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“…Victoria Samanidou, Dimitrios Bitas, Stamatia Charitonos, and Ioannis Papadoyannis, in their review, "On the Extraction of Antibiotics from Shrimps Prior to Chromatographic Analysis", describe the need for sensitive and selective methods of monitoring residue levels in aquaculture species for routine regulatory analysis. It is well known that the widespread use of antibiotics in veterinary practice and aquaculture has led to the increase of antimicrobial resistance in foodborne pathogens that may be transferred to humans [8].…”

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confidence: 99%