On the action of combination bronchodilators

Hanna, Christopher J.; Eyre, P.

doi:10.1007/bf01970652

Cited by 4 publications

(5 citation statements)

References 44 publications

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“…Most investigations on asthmatic patients have only claimed an additive effect (3,7,9,12,13,18,19). Most investigations on asthmatic patients have only claimed an additive effect (3,7,9,12,13,18,19).…”

Section: Disgussionmentioning

confidence: 99%

“…Two other studies have shown a further bronchodilation if Pg-agonists are inhaled on top of optimal theophylline concentrations (2, 24) without proposing a potentiated effect. Most investigations on asthmatic patients have only claimed an additive effect (3,7,9,12,13,18,19). However, interpretation of a result as only indicating an additive effect can be questioned in the light of the results of this study.…”

Section: Disgussionmentioning

confidence: 99%

“…Since then several studies in asthmadcs have appeared, some (4, 21) claiming potentiation, but most only claiming an additive effect (3,7,9,12,13,18,19). This potentiation has also been xanthines function with cyclic AMP as a com-demonstrated in human bronchial muscles in mon mediator, they should interact in a syner-vitro (28, 29).…”

mentioning

confidence: 99%

“…A preliminary report on this part of the study was presented at the Annual Meeting of the American Lung Associadon (30). Since then several studies in asthmadcs have appeared, some (4, 21) claiming potentiation, but most only claiming an additive effect (3,7,9,12,13,18,19).…”

mentioning

confidence: 99%

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Does Theophylline Potentiate Inhaled β₂‐Agonists?

Svedmyr

1982

Allergy

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The influence of pretreatment with equipment bronchodilating doses of intravenous theophyllamine and inhaled terbutaline on the effect of five terbutaline inhalations was investigated in a cross-over study in six adult asthmatics with stable and reproducible bronchoconstriction. Theophylline in a dose giving a maximal mean plasma concentration of 16.7 +/- 1.21 micrograms/ml (92 mumol/l) gave far from maximal acute bronchodilation as the following five terbutaline inhalations gave the same further bronchodilation. Pretreatment with five terbutaline inhalations induced almost equal bronchodilation compared with theophyllamine but the following five inhalations now gave only about one-fourth of the effects recorded after theophyllamine pretreatment. This potentiation could, however, be due to the different routes of administration of the pretreatments. In a randomized, double-blind, cross-over study in eight asthmatic, pretreatment with equipotent oral bronchodilating doses of theophylline and terbutaline was shown to give the same potentiation of the following five terbutaline inhalations. Theoyphylline orally as such thus did not potentiate the effect of inhaled beta 2-stimulants. It had only the same effect as oral terbutaline, but induced less tremor. This means that the potentiation after intravenous and oral pretreatment was not due to theophylline but to the different routes of administrations. Systemic administration probably gave a better distribution and thus better effect of the inhaled terbutaline.

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Section: Disgussionmentioning

confidence: 99%

Section: Disgussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Does Theophylline Potentiate Inhaled β₂‐Agonists?

Svedmyr

1982

Allergy

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“…Co-administration of doxofylline with terbutaline sulphate gives better bronchodilation with a lower degree of skeletal muscle tremor than a higher dose of terbutaline sulphate by mouth alone. Therefore, a fixed-dose combination of doxofylline and terbutaline sulphate is a better alternative for the treatment of acute and chronic asthma, as efficacy and safety goes hand-in-hand [7–11]. …”

Section: Introductionmentioning

confidence: 99%

Stability-Indicating RP-HPLC Method for Simultaneous Estimation of Doxophylline and Terbutalinesulphate in Pharmaceutical Formulations

et al. 2013

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An isocratic, stability-indicating, reversed-phase high-performance liquid chromatography (RP-HPLC) method was developed for the quantitative determination of doxofylline and terbutaline sulphate, used for the treatment of respiratory problems. The chromatographic separation was achieved on a Zorbax-SB Phenyl 250 × 4.6mm × 5 μm column with the mobile phase consisting of a mixture of 25 mM ammonium acetate (pH 5.0) : acetonitrile (85:15 %v/v) at a flow rate of 1.0 ml/min. The eluate was monitored at 274 nm using a PDA detector. Forced degradation studies were performed on the bulk sample of doxofylline and terbutaline sulphate using acid (0.1N HCl), base (0.1N NaOH), oxidation (10% hydrogen peroxide), photolytic, and thermal degradation conditions. Good resolution was observed between the degradants and analytes. Degradation products resulting from the stress studies did not interfere with the detection of doxofylline and terbutaline sulphate, thus the assay is stability-indicating. The method has the requisite accuracy, selectivity, sensitivity, and precision for the simultaneous estimation of doxofylline and terbutaline sulphate in bulk and pharmaceutical dosage forms. The limit of quantitation and limit of detection were found to be 1.16 μg/ml and 0.38 μg/ml for doxofylline, 2.08 μg/ml and 0.62 μg/ml for terbutaline sulphate, respectively.

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β-Phenylethylamine content in marine algae around Turkish coasts

Percot

Yalçın

Aysel

et al. 2009

Botm

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β-Phenylethylamine content was investigated in two green, five brown, and ten red marine algae by gas chromatography/mass spectrometry. β-Phenylethylamine was found in six red algae but was not detected in the brown and green algae studied. The highest amount of β-phenylethylamine was determined in Gelidium crinale (30.42 μg g-1). This is the first report of β-phenylethylamine in the algae tested and also the first to quantify β-phenylethylamine in marine algae.

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On the action of combination bronchodilators

Cited by 4 publications

References 44 publications

Does Theophylline Potentiate Inhaled β₂‐Agonists?

Does Theophylline Potentiate Inhaled β₂‐Agonists?

Stability-Indicating RP-HPLC Method for Simultaneous Estimation of Doxophylline and Terbutalinesulphate in Pharmaceutical Formulations

β-Phenylethylamine content in marine algae around Turkish coasts

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On the action of combination bronchodilators

Cited by 4 publications

References 44 publications

Does Theophylline Potentiate Inhaled β2‐Agonists?

Does Theophylline Potentiate Inhaled β2‐Agonists?

Stability-Indicating RP-HPLC Method for Simultaneous Estimation of Doxophylline and Terbutalinesulphate in Pharmaceutical Formulations

β-Phenylethylamine content in marine algae around Turkish coasts

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Does Theophylline Potentiate Inhaled β₂‐Agonists?

Does Theophylline Potentiate Inhaled β₂‐Agonists?