On-demand transdermal insulin delivery system for type 1 diabetes therapy with no hypoglycemia risks

Fu, Yuqing; Liu, Peng; Chen, Meng; Jin, Tongxia; Wu, Huijing; Hei, Mingyang; Wang, Congrong; Xu, Yufang; Qian, Xuhong; Zhu, Weiping

doi:10.1016/j.jcis.2021.07.126

Cited by 33 publications

(21 citation statements)

References 51 publications

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“…Prolonged and regulated release of insulin Escaped risk of hypoglycemia Lowered the pain of injection due to dissolve of microneedle patch [88] Capped mesoporous silica nanoparticles MSN…”

Section: Insulinmentioning

confidence: 99%

Mesoporous Silica Nanoparticles: Drug Delivery Vehicles for Antidiabetic Molecules

et al. 2023

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Mesoporous silica nanoparticles (MSNs) are promising nanomaterials that are widely used in biomedical applications like drug delivery, diagnosis, bio-sensing and cell tracking. MSNs have been investigated meticulously in the drug-delivery field due to their unique chemical and pharmacokinetic properties, such as highly ordered mesopores, high surface area and pore volume, tuneable pore size, stability, surface functionalisation, and biocompatibility. MSN-based nanocomposites have been used to deliver therapeutic molecules like insulin, GLP-1, exenatide, DPP-4 inhibitor and plasmid-containing GLP-1 genes for managing diabetes mellitus for the last decade. The functionalisation properties of MSNs make them substantially capable of the co-delivery, controlled delivery and stimuliresponsive delivery of antidiabetic drugs. This review focuses on the delivery of antidiabetic therapeutics with special emphasis on the functionalisation of MSNs and stimuliresponsive delivery.

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“…Prolonged and regulated release of insulin Escaped risk of hypoglycemia Lowered the pain of injection due to dissolve of microneedle patch [88] Capped mesoporous silica nanoparticles MSN…”

Section: Insulinmentioning

confidence: 99%

Mesoporous Silica Nanoparticles: Drug Delivery Vehicles for Antidiabetic Molecules

et al. 2023

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“…For example, Fu and coworkers constructed a closed-loop insulin smart delivery system for type 1 diabetes treatment. This closed-loop insulin smart delivery system using HA MNP loaded with smart glucose-responsive PBAs-based mesoporous silica nanoparticles (Fu et al., 2022 ).First, the MNP tip layer was prepared by dispersing GMSN@Insulin@ZnO-PBA-2 into HA solution (0.5 g/mL). Then pure HA solution (1.0 g/mL) was added as the backing layer.…”

Section: Applications Of Ha Mnp As An Excellent Drug Carriermentioning

confidence: 99%

The most promising microneedle device: present and future of hyaluronic acid microneedle patch

et al. 2022

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Microneedle patch (MNP) is an alternative to the oral route and subcutaneous injection with unique advantages such as painless administration, good compliance, and fewer side effects. Herein, we report MNP as a prominent strategy for drug delivery to treat local or systemic disease. Hyaluronic acid (HA) has advantageous properties, such as human autologous source, strong water absorption, biocompatibility, and viscoelasticity. Therefore, the Hyaluronic acid microneedle patch (HA MNP) occupies a large part of the MNP market. HA MNP is beneficial for wound healing, targeted therapy of certain specific diseases, extraction of interstitial skin fluid (ISF), and preservation of drugs. In this review, we summarize the benefits of HA and cross-linked HA (x-HA) as an MNP matrix. Then, we introduce the types of HA MNP, delivered substances, and drug distribution. Finally, we focus on the biomedical application of HA MNP as an excellent drug carrier in some specific diseases and the extraction and analysis of biomarkers. We also discuss the future development prospect of HA MNP in transdermal drug delivery systems (TDDS).

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“…This method does not cause pain and brings light to the minimally invasive treatment of diabetes. [ 180,181 ] Currently, based on the different glucose‐responsive moieties, various closed‐loop insulin delivery systems have been proposed to effectively regulate the blood glucose level of diabetic patients, which include glucose oxidase (GOx) and phenylboronic acid (PBA)…”

Section: Applications Of Mns In Biomedicinementioning

confidence: 99%

Recent Advances in Polymer Microneedles for Drug Transdermal Delivery: Design Strategies and Applications

Wang

Jiang

Aharodnikau

et al. 2022

Macromol. Rapid Commun.

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In recent years, transdermal drug delivery based on microneedles (MNs) technology has received extensive attention, which offers a safer and painless alternative to hypodermic needle injections. They can pierce the stratum corneum and deliver drugs to the epidermis and dermis-structures of skin, showing prominent properties such as minimally invasiveness, bypassing first-pass metabolism, and can be self-administered. A range of materials has been used to fabricate MNs, such as silicon, metal, glass, and polymers. Among them, polymer MNs have gained increasing attention from pharmaceutical and cosmetic companies as one of the promising drug delivery methods. MN products have recently become available on the market, and some of them are under evaluation for efficacy and safety. This paper focuses on the current state of polymer MNs in drug transdermal delivery. The materials and methods for the fabrication of polymer MNs and their drug administration are described. The recent progress of polymer MNs for treatment of cancer, vaccine delivery, blood glucose regulation, androgenetic alopecia, obesity, tissue healing, myocardial infarction, and gout are reviewed. The challenges of MNs technology are summarized and the future development trend of MNs is also prospected.

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On-demand transdermal insulin delivery system for type 1 diabetes therapy with no hypoglycemia risks

Cited by 33 publications

References 51 publications

Mesoporous Silica Nanoparticles: Drug Delivery Vehicles for Antidiabetic Molecules

Mesoporous Silica Nanoparticles: Drug Delivery Vehicles for Antidiabetic Molecules

The most promising microneedle device: present and future of hyaluronic acid microneedle patch

Recent Advances in Polymer Microneedles for Drug Transdermal Delivery: Design Strategies and Applications

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