The most promising microneedle device: present and future of hyaluronic acid microneedle patch

Abstract

Microneedle patch (MNP) is an alternative to the oral route and subcutaneous injection with unique advantages such as painless administration, good compliance, and fewer side effects. Herein, we report MNP as a prominent strategy for drug delivery to treat local or systemic disease. Hyaluronic acid (HA) has advantageous properties, such as human autologous source, strong water absorption, biocompatibility, and viscoelasticity. Therefore, the Hyaluronic acid microneedle patch (HA MNP) occupies a large part of the MNP market. HA MNP is beneficial for wound healing, targeted therapy of certain specific diseases, extraction of interstitial skin fluid (ISF), and preservation of drugs. In this review, we summarize the benefits of HA and cross-linked HA (x-HA) as an MNP matrix. Then, we introduce the types of HA MNP, delivered substances, and drug distribution. Finally, we focus on the biomedical application of HA MNP as an excellent drug carrier in some specific diseases and the extraction and analysis of biomarkers. We also discuss the future development prospect of HA MNP in transdermal drug delivery systems (TDDS).

Tailoring Hyaluronic Acid Hydrogels for Biomedical Applications

“…ISF can be utilized to reflect physiology conditions by detecting changes of its cellular components and biomarkers. [ 116 ] Among all the microneedle patches of tailoring HA hydrogel, HAMA microneedle patches are preferred. They are SMNs that can effectively extract fluidic in one step while maintaining structural integrity after usage.…”

“…[ 233 ] It has been proved that HA can inhibit the recognition between PKCa and CD44 to realize anti‐allergic effect. [ 116 ] More broadly, HA can also remarkably enhance proliferation/migration of keratin‐forming cell and angiogenesis through promoting the generation of vascular endothelial growth factor and adhesion molecules. Additionally, as HA‐based microneedle patch had the advantages of efficient delivery, non‐invasive and painless, it has been regarded as an advantageous carrier to deliver therapeutics to subcutaneous tissues.…”

“…[115] Despite the above, extensive research over the past decades has used SMNs as devices of diagnostic extraction for they can keep a good fit with the skin and absorb a mass amount of ISF. [16,116,117] Offline analysis of metabolites like cholesterol and glucose could be conducted when SMNs were peeled off. In a word, the microneedle patch from tailoring HA hydrogels facilitates the delivery of various therapeutic molecules for different medical aims and presents the potential for diagnosis.…”

“…The loaded drugs in microneedle patch can easily cross the stratum corneum barrier to a subcutaneous target site and accumulate in the local peritumor skin. [116,182] The following Table 1 lists the research of cancer treatment in recent three years by using nanogel, injectable hydrogel and microneedle patch.…”

Characteristics of Hyaluronic Acid and Its Use in Ocular Surface Diseases Including Dry Eye

“…1). 18,19 비록 글리코사미노글리칸에 속하지만, 황 산화되지 않았고, 골지체가 아닌 원형질막에서 형성되고, 분자량이 매우 클 수 있다는 점에서 HA는 다른 글리코사 미노글리칸과 차별성을 가진다. 18 눈에서 HA는 자연적으로 눈물, 각막상피, 그리고 유리체 에서 발견된다.…”