“…Surprisingly, no studies using high doses of H2-receptor antagonists have been reported in patients with reflux oe sophagitis. Interestingly, recent studies using high and very high doses of up to 1,800 mg ranitidine daily have shown that these in creased doses significantly raise intra-oesophageal pH in patients with ulcerative re flux oesophagitis when compared with the recommended lower doses of the drug [17,18]. In the absence of controlled clinical studies on healing of reflux oesophagitis with such high dose of H2-receptor antagonists, other therapeutic options have been ex plored, such as the mucosa-protecting agent sucralfate, the prokinetic drug cisapride and combinations of various modalities [15,17], However, these approaches have not been proven to be superior to treatment with H2-receptor antagonists.…”