Current Trends in the Pharmacotherapy for Gastroesophageal Reflux Disease

Hixson, Lee J.; Kelley, Catherine L.; Jones, William N.; Tuohy, Craig D.

doi:10.1001/archinte.1992.00400160035008

Cited by 19 publications

(1 citation statement)

References 93 publications

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“…[38,39] Indeed, short term treatment of GORD does not eliminate the causes of the disease, and both symptoms and mucosal inflammation recur in many patients. For these children it is necessary to plan maintenance treatment to control symptoms and maintain oesophageal mucosal healing.…”

Section: 4 Maintenance Therapymentioning

confidence: 99%

Role of Drug Therapy in the Treatment of Gastro-Oesophageal Reflux Disorder in Children

et al. 2000

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Gastro-oesophageal reflux (GOR) is the effortless passage of gastric contents into the distal oesophagus. It can be classified as functional (or symptomatic), in which the infant remains free from disease, or a pathological (GOR disease, GORD), in which gastrointestinal, respiratory or neurobehavioural signs occur with intraoesophageal acidification and the development of oesophagitis. Functional or symptomatic GOR is successfully treated by conservative measures and does not require investigative diagnostic tools; however, both drug administration and an investigative approach are mandatory in patients with GORD. There is currently a great range of proven therapeutic options for GORD that are directed at counteracting the pathogenetic components of the disorder. In this report we discuss the role of different drug classes for treating GORD in children. The choice of therapy for GORD depends upon the severity of signs and the degree of oesophagitis. The presence of oesophagitis, as documented by endoscopy, suggests the use of antisecretory drugs; H2 receptor antagonists are the first-line agents. Nevertheless, individuals with refractory disease or those patients requiring potent inhibition of acid secretion (for example, GORD with respiratory involvement) can be given proton pump inhibitors. Other groups of patients who need potent inhibition of acid secretion are children with neurological dysfunction and those with Barrett's oesophagus. It is still unclear whether patients with frequent relapses are candidates for long term administration of antisecretory drugs or for surgical fundoplication.

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Section: 4 Maintenance Therapymentioning

confidence: 99%

Role of Drug Therapy in the Treatment of Gastro-Oesophageal Reflux Disorder in Children

et al. 2000

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Gastroesophageal Reflux Disease and Asthma

Simpson¹

1995

Arch Intern Med

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Gastroesophageal reflux is common among asthmatics. It not only may worsen during an episode of airways obstruction but also may serve as a trigger for such an attack. Both animal and clinical data suggest that gastroesophageal reflux serves as a trigger of bronchospasm, potentiates the bronchomotor response to additional triggers, or both. Patients with reflux-associated asthma may manifest symptoms of gastroesophageal reflux, either classic or atypical, but approximately 25% to 30% have clinically silent reflux. Despite the use of inadequate doses of acid-suppressive medicines, clinical trials have documented improvement in respiratory symptoms among asthmatics following the treatment of reflux. Recent trials suggest long-term improvement in respiratory symptoms following antireflux surgery. Selected patients with asthma should be evaluated for gastroesophageal reflux. If it is present, such patients may benefit from aggressive antireflux therapy.

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Omeprazole Treatment of Children With Peptic Esophagitis Refractory to Ranitidine Therapy

Karjoo

Kane²

1995

Arch Pediatr Adolesc Med

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Current Trends in the Pharmacotherapy for Gastroesophageal Reflux Disease

Cited by 19 publications

References 93 publications

Role of Drug Therapy in the Treatment of Gastro-Oesophageal Reflux Disorder in Children

Role of Drug Therapy in the Treatment of Gastro-Oesophageal Reflux Disorder in Children

Gastroesophageal Reflux Disease and Asthma

Omeprazole Treatment of Children With Peptic Esophagitis Refractory to Ranitidine Therapy

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