2000
DOI: 10.2165/00128072-200002040-00003
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Role of Drug Therapy in the Treatment of Gastro-Oesophageal Reflux Disorder in Children

Abstract: Gastro-oesophageal reflux (GOR) is the effortless passage of gastric contents into the distal oesophagus. It can be classified as functional (or symptomatic), in which the infant remains free from disease, or a pathological (GOR disease, GORD), in which gastrointestinal, respiratory or neurobehavioural signs occur with intraoesophageal acidification and the development of oesophagitis. Functional or symptomatic GOR is successfully treated by conservative measures and does not require investigative diagnostic t… Show more

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Cited by 14 publications
(4 citation statements)
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References 44 publications
(34 reference statements)
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“…Cimetidine is rarely used clinically as there are concerns about its effect on cytochrome P450 and consequent multiple drug interactions, as well as interference with vitamin D metabolism and endocrine function . We could not find any prospective studies of paediatric patients with GERD exposed to cimetidine reporting AEs.…”
Section: Resultsmentioning
confidence: 90%
“…Cimetidine is rarely used clinically as there are concerns about its effect on cytochrome P450 and consequent multiple drug interactions, as well as interference with vitamin D metabolism and endocrine function . We could not find any prospective studies of paediatric patients with GERD exposed to cimetidine reporting AEs.…”
Section: Resultsmentioning
confidence: 90%
“…Rarely used clinically in children due to concerns about drug interactions, and interference with vitamin D metabolism and endocrine function [8] Grade B c Effective in children with GORD, but adverse events preclude its use Famotidine Demonstrated potential benefits in a small study in children with GOR but was associated with significant adverse events [9] No specific recommendation given by Tighe et al [1] Studies in children are limited; further study is needed…”
Section: Cimetidinementioning
confidence: 99%
“…Treatment alternatives for children with GERD include prokinetic agents, acid suppressant therapies, and anti-reflux surgery. Among these, the prokinetics (metoclopramide, domperidone, and bethanechol) are prescribed less frequently because of their potential side effects and the availability of effective acid-suppressant alternatives (25)(26)(27)(28). Surgery is usually reserved for patients with extremely severe GERD and/or GERD that is refractory to pharmacologic intervention.…”
Section: Safety Assessmentsmentioning
confidence: 99%