Lansoprazole in Adolescents with Gastroesophageal Reflux Disease: Pharmacokinetics, Pharmacodynamics, Symptom Relief Efficacy, and Tolerability
Thirumazhisai Gunasekaran,
Sandeep Gupta,
David Gremse
et al.
Abstract:Objectives:To evaluate the pharmacokinetics, pharmacodynamics, symptom relief efficacy, and tolerability of lansoprazole in adolescents between 12 and 17 years of age with gastroesophageal reflux disease (GERD).Methods:Adolescents with symptomatic, endoscopically and/or histologically proven GERD were enrolled in this multicenter, double‐blind trial and randomized to lansoprazole 15 mg or 30 mg once daily for 5 days.Results:Sixty‐three adolescents were enrolled in the study. After lansoprazole administration, … Show more
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