Omentin concentrations are independently associated with those of matrix metalloproteinase-3 in patients with mild but not severe rheumatoid arthritis

Abstract

Omentin is an adipokine that reportedly protects against cardiometabolic risk. We investigated the relationships between omentin concentrations and subclinical cardiovascular disease in rheumatoid arthritis (RA). Omentin concentrations were measured in 213 (104 black; 109 white) RA patients. Relationships of omentin levels with those of endothelial activation markers, ultrasound determined carotid intima-media thickness and plaque, and matrix metalloproteinase (MMP)-2, -3 and -9 that mediate altered plaque stability, were identified in confounder adjusted multivariate regression models. Omentin concentrations were inversely associated with MMP-3 levels [β = -364 (0.113), p = 0.002]. This relationship was influenced by population origin, RA activity and the erythrocyte sedimentation rate and joint deformity count (interaction p value = 0.009, 0.04, 0.04 and 0.007, respectively). Accordingly, the omentin-MMP-3 concentration relationship was reproduced in white [β (SE) = -0.450 (0.153), p = 0.0004)] but not black patients [β (SE) = -0.099 (0.195), p = 0.6)], in participants with disease remission or mild disease activity [β (SE) = -0.411 (0.139), p = 0.004] but not with moderate or severe RA activity [β (SE) = -0.286 (0.202), p = 0.2], and in those with a small [β (SE) = -0.534 (0.161), p = 0.001] but not large erythrocyte sedimentation rate [-0.212 (0.168), p = 0.2] and without [β (SE) = -0.554 (0.165), p = 0.0001] but not with large joint deformity counts [-0.110 (0.173), p = 0.5]. Omentin levels were unrelated to endothelial activation and atherosclerosis. Among patients with RA, a lack of plaque stabilizing effects by omentin may contribute to the reported link between severe disease and increased cardiovascular risk. The association between concentrations of omentin and MMP-3 is population specific in RA.

Omentin: a biomarker of cardiovascular risk in individuals with axial spondyloarthritis

“…As for its anti-atherogenic function, similar to the results obtained in RA by Robinson et al 16 , in our study we did not find any direct association between omentin and surrogate markers of subclinical atherosclerosis (presence of carotid plaques and abnormal cIMT values) in axSpA. Notwithstanding, an association between low serum levels of omentin and CV risk factors such as obesity and AI indicative of dyslipidemia was observed in our axSpA patients.…”

“…For this purpose, in this study we aimed to assess the implication of omentin, a novel adipokine, in the CV risk and subclinical atherosclerosis of axSpA patients. In the last years this molecule has attracted an increasing interest and, consequently, several studies were performed to evaluate the role of omentin in diseases different from axSpA [12][13][14][15][16] . However, despite the clinical importance of the CV risk in axSpA, to the best of our knowledge, this is the first study aimed to address this issue in this chronic inflammatory disease.…”

“…Low levels of this protein have been associated with metabolic dysfunction (insulin resistance, diabetes mellitus (DM) and metabolic syndrome) and CV disease [12][13][14][15] . However, all these studies were performed in conditions different from axSpA such as obesity, coronary artery disease (CAD), DM and rheumatoid arthritis (RA) [12][13][14][15][16] .…”

Associations between Adipokines in Arthritic Disease and Implications for Obesity

“…Similarly, another anti-inflammatory adipokine, omentin, is associated with lower levels of MMP-3 in RA [97], while nesfatin-1 has been found to be inversely associated with carotid IMT (80), suggesting that certain adipokines may protect against cardiovascular disease in RA. Patients with psoriatic arthritis exhibit higher serum levels of omentin and leptin, but lower levels of adiponectin and chemerin, compared with healthy controls [98].…”

Omentin-A Novel Adipokine in Respiratory Diseases

“…Omentin levels were reduced in certain autoimmune diseases, including psoriasis [ 37 , 38 , 39 ], rheumatoid arthritis [ 40 , 41 ], Behcet’s disease [ 42 ], Crohn’s disease [ 43 ], ulcerative colitis [ 44 ], chronic periodontitis [ 45 ], and acute or chronic pancreatitis [ 46 ]. Other studies demonstrated that omentin levels were highly elevated in individuals with psoriatic arthritis compared to individuals with psoriasis alone or healthy individuals [ 47 ], although the precise mechanism underlying these observations is not obvious.…”