Omentin-A Novel Adipokine in Respiratory Diseases

Zhou, Yan; Zhang, Bo; Hao, Caixia; Huang, Xiaoting; Li, Xiaohong; Huang, Yanhong; Luo, Ziqiang

doi:10.3390/ijms19010073

Cited by 53 publications

(46 citation statements)

References 114 publications

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“…This adipokine is involved in lipid metabolism (through inhibiting oxLDL) and proper synthesis of nitric oxide through the inhibition of TNF-alpha-induced cyclooxygenase-2 (COX-2) expression, with further activation of the endothelial nitric oxide synthase (eNOS)/NO pathway [ 54 ]. Moreover, omentin is able to promote the anti-inflammatory M2 phenotype of macrophages during the differentiation of monocytes into macrophages, thus reducing the production of pro-inflammatory factors [ 16 , 19 ]. In this context, the increased ratios of adiponectin/leptin and omentin/leptin observed in our vegetarians may be related to a better metabolic profile in children who consume a well-planned vegetarian diet.…”

Section: Discussionmentioning

confidence: 99%

“…Among these forms, high-molecular weight multimers (HMW) appear to have the highest bioactivity, and the HMW/total adiponectin ratio is a better determinant of metabolic status than total adiponectin alone [ 13 , 14 ]. Omentin, secreted by the stroma cells of adipose tissue, has anti-inflammatory properties via the activation of endothelial nitric oxide synthesis, blood pressure regulation, and by directly influencing blood vessel relaxation [ 15 , 16 , 17 , 18 , 19 ]. Also, vaspin, a member of the serine protease inhibitor family, plays an important role of protecting against inflammation and atherosclerosis [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

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Anti-Inflammatory and Pro-Inflammatory Adipokine Profiles in Children on Vegetarian and Omnivorous Diets

Ambroszkiewicz¹,

Chełchowska²,

Rowicka³

et al. 2018

Nutrients

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Adipose tissue is a highly active endocrine organ that secrets many pro-inflammatory as well anti-inflammatory adipokines. The aim of the study was to assess serum adipokine profile in prepubertal vegetarian and omnivorous children. Sixty-two children on a vegetarian diet and fifty-five children on an omnivorous diet, aged 5 to 10 years, were studied. Dietary assessment was performed using a nutritional software program. Body composition was measured by dual-energy X-ray absorptiometry. Serum concentrations of adipokines: leptin, soluble leptin receptor (sOB-R), adiponectin (total and high molecular weight), resistin, visfatin, vaspin, and omentin were determined by immunoenzymatic assays. Both studied groups of children were comparable in terms of age, weight, height, body mass index, and body composition. Vegetarians had a lower (p = 0.017) leptin/sOB-R ratio and lower serum concentrations of resistin (p = 0.051), compared with omnivores. Average levels of other adipokines did not differ between both groups of children. However, we observed significantly higher ratios of anti-inflammatory to pro-inflammatory adipokines: adiponectin/leptin 0.70 (0.37–0.93) vs 0.39 (0.28–0.74), p = 0.005, and omentin/leptin 0.40 (0.23–0.83) vs. 0.33 (0.15–0.48), p = 0.011 in vegetarians compared with omnivores. A well-planned vegetarian diet might beneficially affect the adipokine profile and inflammatory status expressed by the ratios of anti-inflammatory to pro-inflammatory adipokines in prepubertal children.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory and Pro-Inflammatory Adipokine Profiles in Children on Vegetarian and Omnivorous Diets

Ambroszkiewicz¹,

Chełchowska²,

Rowicka³

et al. 2018

Nutrients

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“…Since 1980 age-standardised diabetes mellitus (DM) prevalence has increased by 110% in men and by 58% in women, reaching, respectively, 9% and 7.9% global prevalence in 2014 1. Such an alarmingly high increasing rate, coupled with population growth and ageing, has led to a near quadrupling of the number of adults with diabetes worldwide who are now estimated to be 422 million1 and projected to rise to 629 million by 2045 2. The highest DM burden is concentrated in low-income and middle-income countries (LMICs).…”

Section: Introductionmentioning

confidence: 99%

Global prevalence of diabetic retinopathy: protocol for a systematic review and meta-analysis

Cheloni¹,

et al. 2019

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IntroductionWith increasing diabetes trends worldwide, morbidity, mortality and associated costs due to diabetes-related complications are a global public health concern. Diabetic retinopathy (DR) is among the leading causes of vision loss at the global level; accurate estimates of DR burden is of crucial importance for planning, implementing and evaluating DR prevention and care interventions.The available evidence on DR prevalence at the global level, dating back to 2008, only considered data from selected regions. Taking into account the rapidly changing patterns in DR epidemiology, the aim of the current study is to carry out a systematic review and meta-analysis to derive solid and updated estimates on global and setting-specific DR prevalence.Methods and analysisThe systematic review methods have been defined following PRISMA guidelines. Studies published from 2008 through 2018 will be identified searching the electronic databases Embase, Medline, Cochrane, ISI Web of Knowledge, as well as through grey literature search. Retrieved records will be independently screened by two authors and relevant data will be extracted from studies reporting data on DR prevalence among individuals with diabetes. Prevalence pooled estimates of any form of DR and vision-threatening DR will be computed applying random-effects meta-analysis. Interstudy heterogeneity will be assessed using the I2 statistic and explored through meta regressions and subgroup analyses. Depending on data availability, we plan to conduct subgroup analyses by study population, diabetes type, DR severity, geographical region and other selected clinical and sociodemographic variables of interest. Quality appraisal of the studies will be performed.Ethics and disseminationEthics approval is not required as this is a review of anonymised published data. Findings of the final report will be shared with the scientific community through publication in a peer-reviewed journal and presentation at conferences, as well as with key stakeholders, including national and international health authorities, health policy makers, healthcare professionals and the general population.Clinical trial registrationCRD42018085260.

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“…For instance, transforming growth factor-β1 and microRNA gene variations have been shown to be associated with CAD in Chinese, Caucasian [9], and Indian cohorts, respectively [10,11,12,13]. Omentin protein (also called intelectin) is a novel adipocytokine secreted by visceral adipose tissues (e.g., retroperitoneal and epicardial fat), intestinal Paneth cells and endothelial cells [14]. It is composed of 313 amino acid residues (35 kDa) and circulates in the human bloodstream.…”

Section: Introductionmentioning

confidence: 99%

“…It is composed of 313 amino acid residues (35 kDa) and circulates in the human bloodstream. There are two isoforms of omentin with amino acid sequence similarity about 83% [14]. Omentin1 is the major isoform in blood and studied more than omentin 2 [14].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Association of Omentin 1 rs2274907 A>T and rs2274908 G>A Gene Polymorphisms with Coronary Artery Disease in Indian Population: A Case Control Study

Jha

Mir

Elfaki

et al. 2019

JPM

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Coronary artery disease (CAD) is a major cause of death all over the world. CAD is caused by atherosclerosis which is induced by the interaction of genetic factors and environmental factors. Traditional environmental risk factors include hyperlipidemia, diabetes mellitus, lack of exercise, obesity, poor diet and others. Genome-wide association studies have revealed the association of certain gene polymorphisms with susceptibility to CAD. Omentin 1 is an adipokine secreted by the visceral adipose tissues and has been reported to have anti-inflammatory, cardioprotective, and enhances insulin sensitivity. In this study, we examined the role of omentin-1 common single nucleotide polymorphisms (SNPs) (rs2274907 A>T and rs2274908 G>A) in CAD. We genotyped 100 CAD patients and 100 matched healthy controls from the south Indian population using an amplification refractory mutation system (ARMS-PCR) and allele-specific PCR (AS-PCR). Our result indicated the rs2274908 G>A is not associated with CAD. Results showed that there was a significant difference in rs2274907 A>T genotype distribution between controls and CAD cases (P-value < 0.05). Results indicated that the AT genotype of the rs2274907 is associated with CAD with OR = 3.0 (95% confidence interval (CI), 1.64 to 5.49), 1.65 (1.27 to 2.163), P = 0.002. The T allele of the rs2274907 was also associated with CAD with OR = 1.82 (95% CI, 1.193 to 2.80), 1.37 (1.08 to 1.74), P = 0.005. Rs2274907 genotype distribution was also correlated with serum total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), hypertension and diabetes. We conclude that the AT genotype and the T allele of the rs2274907 A>T is associated with Cad in the south Indian population. Further studies on the effect of the rs2274907 A>T on omentin-1 function are recommended, and future well-designed studies with larger sample sizes and in different populations are required to validate our findings.

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Omentin-A Novel Adipokine in Respiratory Diseases

Cited by 53 publications

References 114 publications

Anti-Inflammatory and Pro-Inflammatory Adipokine Profiles in Children on Vegetarian and Omnivorous Diets

Anti-Inflammatory and Pro-Inflammatory Adipokine Profiles in Children on Vegetarian and Omnivorous Diets

Global prevalence of diabetic retinopathy: protocol for a systematic review and meta-analysis

Evaluation of the Association of Omentin 1 rs2274907 A>T and rs2274908 G>A Gene Polymorphisms with Coronary Artery Disease in Indian Population: A Case Control Study

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