Olive oil compounds inhibit vascular endothelial growth factor receptor-2 phosphorylation

Lamy, Sylvie; Ouanouki, Amira; Béliveau, Richard; Desrosiers, Richard R.

doi:10.1016/j.yexcr.2013.11.022

Cited by 60 publications

(58 citation statements)

References 51 publications

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“…More recent studies and reviews, for example, by Oliveras-Lopez et al (2014), Garcia-Martinez et al (2014a, 2014b, Estruch et al (2013), Sofi et al (2010) and Fung et al (2009) fit the same general picture presented by Keys (1970) and Martinez-Gonzales et al (2002) and López-Miranda et al (2010) or Lipworth et al (1997). The phenolic compounds, naturally present in EVOO-s are deemed to be of central importance for these beneficial cardiovascular, according to Estruch et al (2013), Fung et al (2009), Valls et al (2015), antiatherogenic/antiinflammatory, Scoditti et al (2014), Lu et al (2013), Cabrerizo et al (2013), anticancer, Hashim et al (2008), Lamy et al (2014), Hashim et al (2014), antioxidant and antimicrobial effects Cicerale et al (2012), Karaosmanoglu et al (2010), Paiva-Martins et al (2013), Giordano et al (2014).…”

Section: Introductionmentioning

confidence: 61%

Labeled extra virgin olive oil as food supplement; phenolic compounds in oils from some autochthonous Croatian olives

et al. 2015

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SUMMARY:Within the framework of an incentive to provide labeled extra virgin olive oils as a food supplement in pharmacies, the phenolic profile analysis of extra virgin olive oils obtained from Croatian olive cultivars has been reported. With the aim of increasing the consumption of EVOO-s in northern Croatia, the varieties Bjelica, Buža and Italian Leccino have been studied involving two different agroclimatic locations, over two harvest years differing significantly in the amount of rainfall. The Croatian cultivars Plominka, Žižolera, Oblica and Lastovka, were also examined. Correlation tests and the insight from PCA reveal that the cultivars are highly individualized in character with regard to relationships among phenolic compounds. Some elements of an innovative labeling aimed to better present the authenticity, quality, excellence and uniqueness of the EVOO-s were suggested. KEYWORDS: Autochthonous Croatian olive varieties; Extra virgin olive oil; Labeling; Phenolic compounds RESUMEN:Aceites de oliva virgen extra etiquetados como suplemento alimenticio; compuestos fenólicos en aceites de aceitunas autóctonas croatas. En el marco de los incentivos que se han considerado para proporcionar el etiquetado de aceites de oliva virgen extra como suplemento alimenticio en farmacias, se reporta el análisis del perfil fenólico de aceites de oliva vírgenes extra obtenidos a partir de variedades croatas. Para ampliar el consumo de AOVE-s en el norte de Croacia, se han estudiado las variedades Bjelica, Buža y Leccino italiana procedentes de dos lugares agroclimáticos diferentes que difieren significativamente en la cantidad de lluvia y obtenidos en dos cosechas. Tambien fueron examinados los cultivares croatas Plominka, Žižolera, Oblica y Lastovka. Los test de correlación y los resultados de PCA revelan que las variedades están altamente individualizados en su carácter en lo que respecta a las relaciones entre los compuestos fenólicos. Se sugirieron algunos elementos innovadores para un etiquetado dirigido a presentar mejor la autenticidad, la calidad, la excelencia y la singularidad de los AOVE-s. PALABRAS CLAVE: Aceite de oliva virgen extra; Compuestos fenólicos; Etiquetado; Variedades de aceitunas autóctonas croatasCitation/Cómo citar este artículo: Jakobušić Brala C, Benčić Ð, Šindrak Z, Barbarić M and Uršić S. 2015. Labeled extra virgin olive oil as food supplement; phenolic compounds in oils from some autochthonous Croatian olives. Grasas Aceites 66 (4): e099. doi: http://dx

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Section: Introductionmentioning

confidence: 61%

Labeled extra virgin olive oil as food supplement; phenolic compounds in oils from some autochthonous Croatian olives

et al. 2015

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“…The main constituent of extra virgin olive oil is the triacylglycerol triolein, which contains three oleic acid (OA) molecules (70%-80% in olive oil). In vitro studies have shown that OA possesses antitumor activity that depends on the type of cancer, and it is linked to the inhibition of angiogenesis (Lamy et al, 2014), metastasis (Suzuki et al, 1997), and proliferation (Hughes-Fulford et al, 2001) as well as the induction of apoptosis (Menendez et al, 2005). OA has a protective effect against chemically-induced lung tumorigenesis (Yamaki et al, 2002), and it inhibits metastasis of Lewis lung carcinoma, although it has no significant effect on the primary solid tumor (Kimura, 2002).…”

Section: Introductionmentioning

confidence: 99%

The Novel Anticancer Drug Hydroxytriolein Inhibits Lung Cancer Cell Proliferation via a Protein Kinase Cα– and Extracellular Signal-Regulated Kinase 1/2–Dependent Mechanism

Guardiola-Serrano

Beteta-Göbel

Rodríguez-Lorca

et al. 2015

J Pharmacol Exp Ther

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Membrane lipid therapy is a novel approach to rationally design or discover therapeutic molecules that target membrane lipids. This strategy has been used to design synthetic fatty acid analogs that are currently under study in clinical trials for the treatment of cancer. In this context, and with the aim of controlling tumor cell growth, we have designed and synthesized a hydroxylated analog of triolein, hydroxytriolein (HTO). Both triolein and HTO regulate the biophysical properties of model membranes, and they inhibit the growth of non-small-cell lung cancer (NSCLC) cell lines in vitro. The molecular mechanism underlying the antiproliferative effect of HTO involves regulation of the lipid membrane structure, protein kinase C-a and extracellular signal-regulated kinase activation, the production of reactive oxygen species, and autophagy. In vivo studies on a mouse model of NSCLC showed that HTO, but not triolein, impairs tumor growth, which could be associated with the relative resistance of HTO to enzymatic degradation. The data presented explain in part why olive oil (whose main component is the triacylglycerol triolein) is preventive but not therapeutic, and they demonstrate a potent effect of HTO against cancer. HTO shows a good safety profile, it can be administered orally, and it does not induce nontumor cell (fibroblast) death in vitro or side effects in mice, reflecting its specificity for cancer cells. For these reasons, HTO is a good candidate as a drug to combat cancer that acts by regulating lipid structure and function in the cancer cell membrane.

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“…Beyond its antiviral effect on HCV, EGCG may have potential use as a chemopreventative agent for hepatocellular cancer as EGCG may inhibit cancer cell growth. This mechanism of action is thought to be due to tyrosine kinase inhibition and modulation of target gene expression associated with induction of apoptosis and cell cycle arrest in cancer cells [28][29][30][31][32][33][34] . GTE is a common ingredient in several dietary supplements, some of which have been withdrawn from the market due to safety concerns.…”

Section: Green Tea Extractmentioning

confidence: 99%

Complementary and alternative medications in hepatitis C infection

Marzio¹,

Fenkel²

2014

WJH

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Chronic hepatitis C (CHC) infection affects almost 3% of the global population and can lead to cirrhosis, liver failure, and hepatocellular carcinoma in a significant number of those infected. Until recently, the only treatments available were pegylated interferon and ribavirin, which traditionally were not very effective and have considerable side effects. For this reason, interest in complementary and alternative medications (CAM) in the management of hepatitis C has been investigated. Some CAM has demonstrated therapeutic potential in chronic hepatitis C treatment. Unfortunately, some CAM has been shown to have the potential to cause drug-induced liver injury. This article will review and evaluate many of the natural molecules that interact with the hepatitis C virus (HC�) life cycle and discuss hepatitis C virus (HC�) life cycle and discuss virus (HC�) life cycle and discuss their potential use and safety in HC� therapy, as well as highlight some important interactions between medical and complementary treatments. Key words: Hepatitis C infection; Natural molecules; Direct acting antivirals; Hepatotoxicity; Herbal treatments Core tip: Over the last 10 years there has been a substantial increase in reports of natural compounds displaying anti-viral activity against hepatitis C. At this time, there is no firm evidence supporting complementary and alternative medications for hepatitis C virus infection.hepatitis C virus infection. virus infection. Due to a limited number of trials and small numbers of subjects included in them, it is not possible to fully evaluate the risk of adverse events connected with the use of these products.Halegoua-De Marzio DL, Fenkel JM. �omplementary and al�omplementary and alternative medications in hepatitis � infection.

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Olive oil compounds inhibit vascular endothelial growth factor receptor-2 phosphorylation

Cited by 60 publications

References 51 publications

Labeled extra virgin olive oil as food supplement; phenolic compounds in oils from some autochthonous Croatian olives

Labeled extra virgin olive oil as food supplement; phenolic compounds in oils from some autochthonous Croatian olives

The Novel Anticancer Drug Hydroxytriolein Inhibits Lung Cancer Cell Proliferation via a Protein Kinase Cα– and Extracellular Signal-Regulated Kinase 1/2–Dependent Mechanism

Complementary and alternative medications in hepatitis C infection

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