Complementary and alternative medications in hepatitis C infection

Marzio, Dina L. Halegoua-De; Fenkel, Jonathan M.

doi:10.4254/wjh.v6.i1.9

Cited by 7 publications

(3 citation statements)

References 92 publications

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“…Além dos IPs de primeira geração, também surgiram os inibidores de nucleotídeos, inibidores nãonucleotídeos do complexo NS5B e inibidores NS5A. Esses medicamentos têm como alvo outras frações da poliproteína sintetizada pelo VHC e seu uso é promissor, pois permitem regimes de tratamento livres de interferon para pacientes com cirrose hepática ou com grau elevado de descompensação hepática 37,[52][53][54][55] .…”

Section: Tratamento Até 2011unclassified

Hepatite C

Perlin

Groto

Perlin

et al. 2019

Rev. Med. (São Paulo)

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O objetivo deste trabalho foi realizar uma revisão da literatura sobre os fármacos utilizados para o tratamento da hepatite C desde a descoberta do vírus, em 1989. Para atingir esse objetivo, foi realizada uma pesquisa nas bases Medline e SciELO, utilizando o termos “hepatite C”, “tratamento”, “livre de interferon”, “revisão” e “ensaio clínico”. Este trabalho apresenta uma revisão das características gerais da hepatite C juntamente com sua epidemiologia e diagnóstico. Durante muito tempo, a única opção disponível para o tratamento da hepatite C foi o interferon. Esta droga não mostrou boa eficácia e seu uso foi minimizado com o surgimento de novos regimes sem interferon que aumentaram a taxa de sucesso para algo em torno de 95%. Tais medicamentos permitiram o alcance real da cura do vírus, embora estejam disponíveis no Sistema Único de Saúde (SUS) brasileiro, são tratamentos caros que restringem o acesso a grande parte da população infectada.

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Section: Tratamento Até 2011unclassified

Hepatite C

Perlin

Groto

Perlin

et al. 2019

Rev. Med. (São Paulo)

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“…Furthermore, the pan-genotypic DAAs have shown promising results (>95%) in complicated patients and have reduced the pill burden [ 4 ]. Nevertheless, during the last few years, an increasing number of reports suggest the availability of complementary and alternative medicines (CAM) as a natural remedy in the use of HCV treatment [ 5 ]. However, user and CAM provider perspectives in the use of CAM in the treatment of HCV have not been explored before.…”

Section: Introductionmentioning

confidence: 99%

Complementary and Alternative Medicines for the Treatment of Hepatitis C: Perspectives of Users and CAM Practitioners

Ali

Ullah

Paudyal

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Background. Despite substantial progress in the treatment of hepatitis C through the use of direct-acting antivirals which have been shown to cure the disease, complementary and alternative medicines (CAM) are popular among patients as a substitute or complement of allopathic medicines. This study aimed to explore the perspectives of patients and CAM practitioners on the use of CAM for the treatment of hepatitis C in Pakistan. Methods. A cross-sectional design was adopted. Participants (CAM practitioners and patients) were recruited from the capital and two provinces: Khyber Pakhtunkhwa and Punjab of Pakistan. A survey using paper-based questionnaires, each specific for patients and CAM practitioners, was conducted to gather information pertaining to demography, disease status, treatment history, and participants’ perspectives (about the disease, reasons to switch to CAM, and referring source). Results. A total of 417 respondents (n = 284 patients, n = 133 practitioners) were recruited. Of the total patients, 170 (59.9%) had started CAM during the previous three months. There were 168 (59.2%) of the total patients who had used allopathic treatments for hepatitis C prior to their use of CAM. The confidence in CAM (24.6%), high cost (19%), and unbearable side effects (52.1%) of allopathic medicines were the main reasons to switch to CAM treatment. Majority (49.3%) of the patients were referred to CAM on the recommendations of relatives or care givers (17.3%) whereas only 9.5% were referred by health care professionals. Out of 133 practitioners, 48 (36.1%) were practicing herbal medicines. From practitioners’ perspectives, club-moss (Lycopodium clavatum) was the best treatment option for hepatitis C. The majority, 73 (54.9%), of the patients had chosen to use CAM because of the side effects of allopathic medicines. Patients who had previous “good experience” with CAM were the most common referral source (56.4%) for CAM use in hepatitis C. Conclusions. Patients’ beliefs in CAM, side effects of allopathic therapy, high cost of allopathic medicines, and referrals from previous CAM users are key factors in the switching of hepatitis C patients to CAM.

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“…The practice of complementary and alternative medicine (CAM) has increased worldwide, and CAM showed several beneficial effects for many chronic diseases. 5 Moreover, many people tend to use CAM, including, Ayurveda, traditional Chinese medicine (TCM), and Unani medicine throughout the world, especially when the conventional treatments fail. According to a previous survey-based study, nearly 80% of patients with HCV infection had used CAM to improve their wellbeing and reduce the symptoms of the disease.…”

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confidence: 99%