Oligoarginine mediated collagen/chitosan gel composite for cutaneous wound healing

Li, Manman; Han, Mei; Sun, Yusheng; Hua, Yingying; Chen, Guifang; Zhang, Liefeng

doi:10.1016/j.ijbiomac.2018.09.061

Cited by 67 publications

(36 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Cellulose is a nanostructured biomaterial; its similarity to ECM has attracted great potential in wound healing scaffolds for several applications in tissue repair, remodeling or skin transplantation [ 107 ].…”

Section: Scaffold For Skin Regenerationmentioning

confidence: 99%

Skin Wound Healing Process and New Emerging Technologies for Skin Wound Care and Regeneration

et al. 2020

View full text Add to dashboard Cite

Skin wound healing shows an extraordinary cellular function mechanism, unique in nature and involving the interaction of several cells, growth factors and cytokines. Physiological wound healing restores tissue integrity, but in many cases the process is limited to wound repair. Ongoing studies aim to obtain more effective wound therapies with the intention of reducing inpatient costs, providing long-term relief and effective scar healing. The main goal of this comprehensive review is to focus on the progress in wound medication and how it has evolved over the years. The main complications related to the healing process and the clinical management of chronic wounds are described in the review. Moreover, advanced treatment strategies for skin regeneration and experimental techniques for cellular engineering and skin tissue engineering are addressed. Emerging skin regeneration techniques involving scaffolds activated with growth factors, bioactive molecules and genetically modified cells are exploited to overcome wound healing technology limitations and to implement personalized therapy design.

show abstract

Section: Scaffold For Skin Regenerationmentioning

confidence: 99%

Skin Wound Healing Process and New Emerging Technologies for Skin Wound Care and Regeneration

et al. 2020

View full text Add to dashboard Cite

show abstract

“…The FTIR spectrum of HC showed bands of amide A (3,383 cm −1 ), amide B (3,087 cm −1 ), amide I (1,660 cm −1 ) suggesting C = O stretching, amide II (1544 cm −1 ) indicating N‐H folding and C‐N deformation, and amide III (1,240 cm −1 ) for C‐N deformation. (Duan, Yuan, Yang, Cheng, & Li, 2016; Kozlowska & Kaczmarkiewicz, 2019; Li, Han, et al, 2019).…”

Section: Resultsmentioning

confidence: 99%

Microwave‐assisted extraction of bioactive compounds fromAraucaria angustifoliabracts followed by encapsulation

Dorneles

Noreña

2020

J Food Process Preserv

View full text Add to dashboard Cite

The aqueous extract of Araucaria angustifolia bracts was obtained by microwave‐assisted extraction and encapsulated by spray‐drying and freeze‐drying using pectin/hydrolyzed collagen (PEC‐HC) and polydextrose/partially hydrolyzed guar gum (PD‐PHGG) dispersions, added to the extract in the proportions of 0.25:0.75:9 and 0.5:0.5:9 (wt/wt/wt), respectively. The powders encapsulated with the PD‐PHGG mixture by spray‐drying and freeze‐drying showed the highest retention rates for total phenolic compounds (80.57% and 89.94%) and solubility (98.00 and 97.69 g 100 g−1), respectively. The scanning electron microscopy (SEM) images presented spherical forms on the spray‐dried powders, while the freeze‐dried powders exhibited irregular forms. The results obtained by FTIR suggested that the encapsulation occurred in all samples by physical interactions, whereas the thermogravimetric analysis showed that the PEC‐HC powders demonstrated greater thermal stability. Accelerated storage tests indicated that the PD‐PHGG freeze‐dried powders had lower decrease in the antioxidant capacity. Practical applications The industrial use of Araucaria angustifolia bracts (sterile seeds) is currently considered a type of waste. However, the bracts present bioactive compounds, including condensed tannins, considered among phenolic compounds, the most important natural antioxidants. The phenolic compounds of the bracts were extracted by microwave, using exclusively water as a solvent. The application of green technologies is an interesting alternative for the food industry since the use of organic solvents is completely replaced, as well shorter exposure times to high temperatures are obtained and, consequently, lower energy expenditure and lower antioxidant capacity loss. For the encapsulation of phenolic compounds, dietary fibers and protein were used as wall materials, which resulted in a powder containing natural antioxidants, fibers, and essential amino acids, which can be applied in several food formulations.

show abstract

“…Different endothermic denaturation peaks may be seen viz. : II, 185 • C; III, 200 • C; and IV, 152 • C. Collagen materials exposed to high temperatures endure irreversible denaturation process [81][82][83][84][85][86]. Previous thermo-analytical studies of denaturation of collagen report that the denaturation temperature for bovine skin is 55 • C [87], bovine intramuscular connective tissue 90 • C [88], rat tail collagen 65 • C [89], bovine skin 50-55 • C [84], and type I collagen from bovine skin soluble in acid 117 • C [90].…”

Section: Differential Scanning Calorimetry (Dsc)mentioning

confidence: 99%

Bovine Decellularized Amniotic Membrane: Extracellular Matrix as Scaffold for Mammalian Skin

et al. 2020

View full text Add to dashboard Cite

Decellularized membranes (DM) were obtained from bovine amniotic membranes (BAM) using four different decellularization protocols, based on physical, chemical, and mechanical treatment. The new material was used as a biological scaffold for in vitro skin cell culture. The DM were characterized using hematoxylin-eosin assay, scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR-ATR), and differential scanning calorimetry (DSC). The in vitro cytotoxicity of DM was evaluated using MTT. The efficacy of decellularization process was assessed through DNA quantification and electrophoresis. All the used protocols showed a high effectiveness in terms of elimination of native cells, confirmed by DNA extraction and quantification, electrophoresis, and SEM, although protocol IV removes the cellular contents and preserve the native extracellular matrix (ECM) architecture which it can be considered as the most effective in terms of decellularization. FTIR-ATR and DSC on the other hand, revealed the effects of decellularization on the biochemical composition of the matrices. There was no cytotoxicity and the biological matrices obtained were a source of collagen for recellularization. The matrices of protocols I, II, and III were degraded at day 21 of cell culture, forming a gel. The biocompatibility in vitro was demonstrated; hence these matrices may be deemed as potential scaffold for epithelial tissue regeneration.

show abstract

Oligoarginine mediated collagen/chitosan gel composite for cutaneous wound healing

Cited by 67 publications

References 30 publications

Skin Wound Healing Process and New Emerging Technologies for Skin Wound Care and Regeneration

Skin Wound Healing Process and New Emerging Technologies for Skin Wound Care and Regeneration

Microwave‐assisted extraction of bioactive compounds fromAraucaria angustifoliabracts followed by encapsulation

Bovine Decellularized Amniotic Membrane: Extracellular Matrix as Scaffold for Mammalian Skin

Contact Info

Product

Resources

About