Olfactory Hypersensitivity in Migraineurs: A H<sub>2</sub><sup>15</sup>O-PET Study

Demarquay, Geneviève; Royet, Julien; Mick, G.; Ryvlin, Philippe

doi:10.1111/j.1468-2982.2008.01672.x

Cited by 97 publications

(99 citation statements)

References 80 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Multiple studies have confirmed that migraine subjects are bothered by odors, especially noxious stimuli [7,8], and that odors may precipitate attacks. One H 2 O-PET study showed abnormal cerebral activation patterns during olfactory stimulation in migraineurs with olfactory hypersensitivity [9]. The ability of persons with migraine to detect and discriminate odors, as determined by standardized olfactory testing, is less clear.…”

Section: Introductionmentioning

confidence: 99%

Olfactory function in migraine both during and between attacks

et al. 2014

View full text Add to dashboard Cite

Introduction People with migraine often report being osmophobic, both during and between acute migraine attacks. It is not clear, however, whether such reports are associated with changes in olfaction such as hyperosmia, as measured by psychophysical testing. In this case-control study we quantitatively assessed olfactory identification ability, which correlates with threshold tests of olfactory acuity, in patients with migraine at baseline (no headache), during migraine episodes, and after a treated attack and compared the test scores to those of matched control subjects. Methods Fifty episodic migraine subjects and 50 and sex- and age-matched controls without headache were tested. All completed the University of Pennsylvania Smell Identification Test (UPSIT), a standardized and well-validated olfactory test. Results At baseline, the UPSIT scores did not differ significantly between the migraine and control study groups (median paired score difference: −1, p = 0.18). During migraine attacks, a minority of migraine subjects (eight of 42) developed microsmia (i.e. lower test scores by at least four points), suggesting that, as compared to their matched controls, olfactory acuity was somewhat impaired during migraine attacks ( p = 0.02). This difference was less pronounced and not statistically significant after a successfully treated attack ( p = 0.15). Discussion People with episodic migraine were found to have similar olfactory function as age- and sex-matched controls, but a minority exhibit microsmia or hyposmia during acute attacks. The cause of this dysfunction is unknown, but could relate to autonomic symptoms, limbic system activation, or disorders of higher order sensory processing.

show abstract

Section: Introductionmentioning

confidence: 99%

Olfactory function in migraine both during and between attacks

et al. 2014

View full text Add to dashboard Cite

show abstract

“…9,12 However, there were six other studies where pathophysiological aspects of the association between odours and migraine were studied. 6,10,21,23,25,27 Frequency of osmophobia during headache attacks in migraine patients ranged from 20.0-95.5%. When studies compared patients with migraine, tension-type headache, and cluster headache, osmophobia predominated in migraine patients.…”

Section: Resultsmentioning

confidence: 99%

“…Generally, we observed a severe intolerance to odours, pleasant or unpleasant, during headache attacks. 2,[4][5][6][7][8]10,11,[13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30] However, a limited number of studies showed that odours may trigger headache attacks in some patients, particularly in migraineurs 1,3,6,7,9,24 and occasionally in cluster headache patients. 12,18 This intolerance to odours is known as osmophobia, and according to two studies that investigated osmophobia in secondary headaches, it occurred during headache attacks only in the primary headaches.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Osmophobia and Odour-triggered Headaches – Review of the Literature and Main Research Centres

Silva‐Néto¹,

Soares²

2017

European Neurological Review

View full text Add to dashboard Cite

There is an important relationship between odours and primary headaches. Patients may present osmophobia during headaches and odours may trigger headache attacks. This review aimed to describe the studies on osmophobia, odour-triggered headache, the main researchers and their research centres. Publications on the relationship between odours and primary headaches were searched in 193 sovereign countries and 48 dependent territories in all continents. We consulted the PubMed database and used the descriptors: "osmophobia in [name of the country or territory]"; "odours and headache in [name of the country or territory]" and "smell and headache in [name of the country or territory]". A total of 254 articles were found, but only 31 articles were considered relevant and composed this review. Of the 31 articles, 90.3% were cross-sectional studies, 6.5% case reports and 3.2% systematic reviews. All studies were performed on three continents: Europe (45.2%), America (32.2%) and Asia (22.6%). For the purpose of this study, North America and South America have been classed as one continent. No research was developed in Africa or Australia. More than 50.0% of the studies were conducted in Italy and Brazil. Only five authors published 38.7% of the studies. Osmophobia during headache attacks was investigated in 67.7% of studies, and odour-triggered headache in 19.3%. Studies on osmophobia and/or odour-triggered headache were carried out in several countries. They were useful in differentiating between migraine and tension-type headache. This could improve the accuracy of diagnosis of migraine compared to the current criteria.

show abstract

“…However, osmophobia may be present in the absence of pain (period between attacks) [2,3,8,9,15,17,19,20]. According to the diagnostic criteria of the International Classification of Headache Disorders, third edition (beta version) (ICHD-3β), patients with migraine have nausea and/or vomiting or photophobia and phonophobia during headache.…”

Section: Introductionmentioning

confidence: 99%