Olfactory conditioning in the zebrafish (Danio rerio)

Braubach, Oliver; Wood, Heather-Dawn; Gadbois, Simon; Fine, Alan; Croll, Roger P.

doi:10.1016/j.bbr.2008.10.044

Cited by 97 publications

(72 citation statements)

References 32 publications

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“…Appetitive olfactory behavior (also see Olfactory response): Increased rate of swimming and distance traveled with frequent directional changes (>90 o turns) that serve to sample appetitive odor plumes (e.g., L-alanine, food extract). [73][74][75] Once visual contact with food is established, approach and nibbling behaviors are displayed. 1.8.…”

Section: Aggregation Behaviormentioning

confidence: 99%

Towards a Comprehensive Catalog of Zebrafish Behavior 1.0 and Beyond

et al. 2013

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Zebrafish (Danio rerio) are rapidly gaining popularity in translational neuroscience and behavioral research. Physiological similarity to mammals, ease of genetic manipulations, sensitivity to pharmacological and genetic factors, robust behavior, low cost, and potential for high-throughput screening contribute to the growing utility of zebrafish models in this field. Understanding zebrafish behavioral phenotypes provides important insights into neural pathways, physiological biomarkers, and genetic underpinnings of normal and pathological brain function. Novel zebrafish paradigms continue to appear with an encouraging pace, thus necessitating a consistent terminology and improved understanding of the behavioral repertoire. What can zebrafish 'do', and how does their altered brain function translate into behavioral actions? To help address these questions, we have developed a detailed catalog of zebrafish behaviors (Zebrafish Behavior Catalog, ZBC) that covers both larval and adult models. Representing a beginning of creating a more comprehensive ethogram of zebrafish behavior, this effort will improve interpretation of published findings, foster cross-species behavioral modeling, and encourage new groups to apply zebrafish neurobehavioral paradigms in their research. In addition, this glossary creates a framework for developing a zebrafish neurobehavioral ontology, ultimately to become part of a unified animal neurobehavioral ontology, which collectively will contribute to better integration of biological data within and across species.

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Section: Aggregation Behaviormentioning

confidence: 99%

Towards a Comprehensive Catalog of Zebrafish Behavior 1.0 and Beyond

et al. 2013

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“…Under classical conditioning, adult zebrafish learn to direct their swimming in response to visual stimuli (e.g. Darland and Dowling, 2001;Sison and Gerlai, 2010;Bianco et al, 2011) and to forage in response to synthetic chemicals (Braubach et al, 2009). Young larvae (6-8 dpf ) can similarly be trained to exhibit tail-flicking behavior in response to light by pairing it with touching by a probe (Aizenberg and Schuman, 2011).…”

Section: Larvae Learn To Sense Flowmentioning

confidence: 99%

“…This would appear to be possible because zebrafish are capable of associative learning. For example, adults can be trained to exhibit feeding behavior in response to a conditioned olfactory stimulus under classical conditioning (Braubach et al, 2009). From an early age, zebrafish are also responsive to operant conditioning.…”

Section: Introductionmentioning

confidence: 99%

Zebrafish learn to forage in the dark

Carrillo

McHenry

2016

Journal of Experimental Biology

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A large diversity of fishes struggle early in life to forage on zooplankton while under the threat of predation. Some species, such as zebrafish (Danio rerio), acquire an ability to forage in the dark during growth as larvae, but it is unclear how this is achieved. We investigated the functional basis of this foraging by video-recording larval and juvenile zebrafish as they preyed on zooplankton (Artemia sp.) under infrared illumination. We found that foraging improved with age, to the extent that 1-month-old juveniles exhibited a capture rate that was an order of magnitude greater than that of hatchlings. At all ages, the ability to forage in the dark was diminished when we used a chemical treatment to compromise the cranial superficial neuromasts, which facilitate flow sensing. However, a morphological analysis showed no developmental changes in these receptors that could enhance sensitivity. We tested whether the improvement in foraging with age could instead be a consequence of learning by raising fish that were naïve to the flow of prey. After 1 month of growth, both groups foraged with a capture rate that was significantly less than that of fish that had the opportunity to learn and indistinguishable from that of fish with no ability to sense flow. This suggests that larval fish learn to use water flow to forage in the dark. This ability could enhance resource acquisition under reduced competition and predation. Furthermore, our findings offer an example of learning in a model system that offers promise for understanding its neurophysiological basis.

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“…In teleost fish, olfactory responses to amino acids or to amino acid derivatives have been linked to feeding (Braubach et al, 2009), as well as to home stream imprinting (Shoji et al, 2003;Yamamoto et al, 2010;Bandoh et al, 2011), pheromone communication (Yambe et al, 2006) and kin recognition (Hinz et al, 2013). Amino acids activate olfactory sensory neurons that project to the rostral lateral olfactory bulb region, and sensory neurons projecting to the more medial bulbar regions respond to bile salts and pheromones (steroids or prostaglandins), except in zebrafish where a reproductive pheromone activates a central portion in the ventral olfactory bulb region (catfish -Nikonov and Caprio, 2001;Hansen et al, 2003;zebrafish -Friedrich andKorsching, 1997, 1998;andsalmonidsHara andZhang, 1996, 1998).…”

Section: Introductionmentioning

confidence: 99%

Odorant organization in the olfactory bulb of the sea lamprey

Green

Boyes

McFadden

et al. 2017

Journal of Experimental Biology

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Olfactory sensory neurons innervate the olfactory bulb, where responses to different odorants generate a chemotopic map of increased neural activity within different bulbar regions. In this study, insight into the basal pattern of neural organization of the vertebrate olfactory bulb was gained by investigating the lamprey. Retrograde labelling established that lateral and dorsal bulbar territories receive the axons of sensory neurons broadly distributed in the main olfactory epithelium and that the medial region receives sensory neuron input only from neurons projecting from the accessory olfactory organ. The response duration for local field potential recordings was similar in the lateral and dorsal regions, and both were longer than medial responses. All three regions responded to amino acid odorants. The dorsal and medial regions, but not the lateral region, responded to steroids. These findings show evidence for olfactory streams in the sea lamprey olfactory bulb: the lateral region responds to amino acids from sensory input in the main olfactory epithelium, the dorsal region responds to steroids (taurocholic acid and pheromones) and to amino acids from sensory input in the main olfactory epithelium, and the medial bulbar region responds to amino acids and steroids stimulating the accessory olfactory organ. These findings indicate that olfactory subsystems are present at the base of vertebrate evolution and that regionality in the lamprey olfactory bulb has some aspects previously seen in other vertebrate species.

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Olfactory conditioning in the zebrafish (Danio rerio)

Cited by 97 publications

References 32 publications

Towards a Comprehensive Catalog of Zebrafish Behavior 1.0 and Beyond

Towards a Comprehensive Catalog of Zebrafish Behavior 1.0 and Beyond

Zebrafish learn to forage in the dark

Odorant organization in the olfactory bulb of the sea lamprey

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