Olea europaea leaf extract exerts L-type Ca2+ channel antagonistic effects

Scheffler, A.; Rauwald, HW; Kampa, Bettina; Mann, Ulrich; Mohr, Friedrich W.; Dhein, Stefan

doi:10.1016/j.jep.2008.08.018

Cited by 62 publications

(48 citation statements)

References 29 publications

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“…It has been documented that olive leaf extract had Ca 2+ channelblocking activity (Gilani et al, 2005;Scheffler et al, 2008). Several investigators have reported that calcium ion has a physiological role in the regulation of pain sensitivity, and inhibition of calcium movement contributes to antinociception (Galeotti et al, 2004;Weiss and De Waard, 2006).…”

Section: Introductionmentioning

confidence: 99%

Olive (Olea europaea L.) leaf extract elicits antinociceptive activity, potentiates morphine analgesia and suppresses morphine hyperalgesia in rats

Esmaeili‐Mahani

Rezaeezadeh-Roukerd

Esmaeilpour

et al. 2010

Journal of Ethnopharmacology

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Section: Introductionmentioning

confidence: 99%

Olive (Olea europaea L.) leaf extract elicits antinociceptive activity, potentiates morphine analgesia and suppresses morphine hyperalgesia in rats

Esmaeili‐Mahani

Rezaeezadeh-Roukerd

Esmaeilpour

et al. 2010

Journal of Ethnopharmacology

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“…Its benefits, however, have been known for centuries, and it has been traditionally used to prevent and treat different diseases. Experimental animal studies on different total olive leaf extracts (OLE) or their constituents have demonstrated hypoglycaemic [1,2], hypotensive [3,4], antiarrhythmic [5], anti-atherosclerotic [6] and vasodilator effects [7]. OLE ameliorates experimental autoimmune encephalomyelitis [8].…”

Section: Introductionmentioning

confidence: 99%

Antioxidant effect of dry olive (Olea europaea L.) leaf extract on ethanol-induced gastric lesions in rats

Dekanski¹,

Ristić²,

Mitrović³

2009

Mediterr J Nutr Metab

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“…Moreover, Ang II plays a significant role in renal fibrosis in immunoglobulin A nephropathy patients (Wen-lun, Yun-yun, Yu, & Hui-deng, 2016). However, the potential of olive leaf treatments in reducing diabetic complications, the possible contribution of the Ang II, as a central target for the anti-diabetic potential of olive, where the treatment of diabetic group with OLE in the present study showed decrease in Ang II content in the kidney tissue, could be attributed to the oleuropein which is the key hypotensive component of OLE due to L-type Ca 2+ channel antagonistic effects (Scheffler, Rauwald, Kampa, Mann, Mohr, et al, 2008). In addition, verbascoside has been demonstrated to inhibit angiotensinconverting enzyme in vitro (Kang, Lee, Kim, Lee, & Lee, 2003) as has oleacein (Hansen, Adsersen, Christensen, Jensen, Nyman, et al, 1996).…”

Section: Discussionmentioning

confidence: 53%

Influences of olive leaf extract in the kidney of diabetic pregnant mice and their offspring

Mohammed

Okail

Ibrahim

et al. 2018

JoBAZ

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Background: Phytotherapeutic treatment is used in the treatment of diabetes and its complications. The current study aims to evaluate the significant effect of supplementation of aqueous olive leaf extract (OLE) (Olea europaea) in the kidney of diabetic pregnant mice and their fetuses. Forty pregnant mice were divided into four groups contained 10 mice each after mating. The first group was the control (G1). The second group (GII) was intraperitoneally injected by a single dose of (240 mg/kg body weight) of streptozotocin (STZ). The third group (GIII) was administrated with a daily oral dose of extract of olive leaf extract (100 mg/kg) from days 1 to 18 of gestation. The fourth group (GIV) was injected intraperitoneally by a single dose of (240 mg/kg body weight) of STZ and post-treatment with oral dose of extract of olive leaves from days 1 to day 18 of gestation. Results: Both mothers and their fetuses of STZ-induced diabetic group showed a decrease in weight compared to control and diabetic group supplemented OLE extract. According to the biochemical and histopathological observations, the STZ-induced diabetic group showed a significant (P < 0.05) increase in serum urea and creatinine levels parallel with detectable histopathological changes in kidney tissues of pregnant mice and their fetuses. Moreover, there was a significant decrease in serum urea and creatinine (P < 0.05) of diabetic mother group under treatment with OLE as compared to diabetic mice. Also, histological findings showed improved renal architecture as reflected by reduced glomerular and tubular necrosis in pregnant mice and their fetuses when compared with control group. Also, there was an increase in the anti-angiotensin II (Ang II) immunoreactivity in renal tubules, intraglomerular, and interstitial cells in the kidney tissue of STZ-induced diabetic group which was markedly improved by treatment with OLE.

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Olea europaea leaf extract exerts L-type Ca2+ channel antagonistic effects

Cited by 62 publications

References 29 publications

Olive (Olea europaea L.) leaf extract elicits antinociceptive activity, potentiates morphine analgesia and suppresses morphine hyperalgesia in rats

Olive (Olea europaea L.) leaf extract elicits antinociceptive activity, potentiates morphine analgesia and suppresses morphine hyperalgesia in rats

Antioxidant effect of dry olive (Olea europaea L.) leaf extract on ethanol-induced gastric lesions in rats

Influences of olive leaf extract in the kidney of diabetic pregnant mice and their offspring

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