Influences of olive leaf extract in the kidney of diabetic pregnant mice and their offspring

Mohammed, Hend A.; Okail, Hanan A.; Ibrahim, Mohamed T.; Emam, Nahed Mohamed Mansour

doi:10.1186/s41936-018-0024-8

Cited by 6 publications

(3 citation statements)

References 56 publications

(41 reference statements)

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“…However, pretreatment of oleuropein at the different doses prevented the formation of these effects. Moreover, Ahmadvand and his co‐workers indicated that oleuropein was able to ameliorate oxidative stress induced renal damages in diabetic rats . This ameliorative property was attributed to the antioxidative and antiatherogenic activities of oleuropein.…”

Section: Introductionmentioning

confidence: 96%

The efficacy of oleuropein against non‐steroidal anti‐inflammatory drug induced toxicity in rat kidney

Koç

Çeriğ

Özek

et al. 2018

Environmental Toxicology

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Indomethacin is generally used in clinical therapeutics as a non-steroidal anti-inflammatory drug.However, its use has been limited due to the gastrointestinal and renal toxic effects of this drug.These toxic effects were associated with not only the inhibition of prostaglandin synthesis but also drug-elevated oxidative stress. To ameliorate these toxicities, natural antioxidants can be used as an alternative and/or combination therapies. Therefore, the current study was conducted to assess the renoprotective effects of oleuropein against indomethacin-induced renal damages. Male Sprague-Dawley rats were pretreated with oleuropein (75, 150, and 300 mg/kg), and then treated with indomethacin (25 mg/kg). To evaluate kidney function, serum blood urea nitrogen, uric acid, and creatinine were measured. In addition, prostaglandin E 2 , tumor necrosis factor-alpha, endothelial nitric oxide synthase, caspase-3, oxidant/antioxidant status, and 8-Oxo-2 0 -deoxyguanosine levels were determined for the antioxidative and anti-inflammatory effects of oleuropein. Tissue sections were also histopathologically assessed. The biochemical and histopathological analysis proved the toxic effects of indomethacin on kidney. However, the pretreatment with oleuropein (300 mg/kg) protects kidney from indomethacin-induced damages. Our study proved that prior administration of oleuropein has renoprotective activity against indomethacin-associated toxicities. K E Y W O R D S8-OHdG, eNOS, histopathologic assessment, oleuropein, prostaglandin E2

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Section: Introductionmentioning

confidence: 96%

The efficacy of oleuropein against non‐steroidal anti‐inflammatory drug induced toxicity in rat kidney

Koç

Çeriğ

Özek

et al. 2018

Environmental Toxicology

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“…The underlying inflammation of the pancreatic parenchyma and the associated subsequent fibrotic destruction are common pathogenic factors in CP and represent targets for protection by modulating the pancreatic inflammation [ 53 , 54 ]. Laboratory research emphasized that the proliferation of ROS is a trigger for inflammation in CP because they activate the signaling cascades that convert the highly damaged acinar cells into chemokines and cytokines production sites [ 55 ].…”

Section: Discussionmentioning

confidence: 99%

Antioxidant, anti-inflammatory, and anti-fibrotic properties of olive leaf extract protect against L-arginine induced chronic pancreatitis in the adult male albino rat

et al. 2022

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Chronic pancreatitis (CP) is an inflammatory disease affects the pancreas with upcoming fibrosis and notable parenchymal destruction. CP poses a high risk for pancreatic carcinoma. The present study aimed to investigate, for the first time up to our knowledge, the effect of olive leaf extract on L-arginine induced CP with referral to some of its underlying mechanisms. Forty adult male albino rats were divided equally into four groups; control, olive leaf extract treated (200 mg/ kg orally once daily), CP group (300 mg L-arginine/100 g body weight intraperitoneally, once daily for 3 weeks then every 3 days for the subsequent 3 weeks), and CP treated with olive leaf extract group. At the end of the experiment, body weight, serum glucose, serum insulin, homeostatic model assessment of insulin resistance (HOMA-IR), serum amylase and lipase as well as tissue superoxide dismutase (SOD), and malondialdehyde (MDA) levels were assessed. Pancreatic tissues were subjected to histological and immuno-histochemical studies. The CP group revealed significant decrease in body weight and increase in serum glucose, serum insulin, HOMA-IR score, serum amylase, and serum lipase levels. Significant increase in MDA level and decrease in SOD level were detected. Marked degenerative changes and fibrosis were detected. Upregulation of alpha smooth muscle actin (α-SMA), transforming growth factor beta (TGF-β), caspase-3, and interleukin-6 (IL-6) immunoreactions were implicated in CP pathogenesis. Olive leaf extract alleviated all the examined parameters via itsantioxidant, anti-inflammatory, and anti-fibrotic properties. Olive leaf extract can protect against CP and restore pancreatic functions.

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“…Inspired by the well-known health benefit of the Mediterranean diet, we hereby assessed the potency of oleuropein, a major phenolic extract of olives that has been shown to be safe to pregnant mice (25), in treating GDM in a genetic modified Lep db/+ (db/+) mouse model. This model harbors a mutated leptin receptor gene Lepr leading to abnormalities closely resembling human GDM symptoms during pregnancy and has been extensively used to evaluate drugs for treating GDM (26).…”

Section: Discussionmentioning

confidence: 99%

Oleuropein alleviates gestational diabetes mellitus by activating AMPK signaling

Zhang

Zhao

Wang

2021

Endocrine Connections

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Background: Gestational diabetes mellitus (GDM) has a high incidence rate among pregnant women. The objective of the study was to assess the effect of plant-derived oleuropein in attenuating inflammatory and oxidative stress of GDM. Methods: Oleuropein was administered to GDM mice at the doses of 5 or 10 mg/kg/day. Body weight, blood glucose, insulin and hepatic glycogen levels were recorded. To evaluate the effect of oleuropein in reducing oxidative stress, enzyme-linked immunosorbent assay (ELISA) was used to measure the hepatic oxidative stress markers. The inflammation levels of GDM mice were evaluated by measuring serum levels of IL-6 and TNF-α by ELISA, and mRNA levels of IL-1β, TNF-α and IL-6 by real-time PCR (RT-PCR). The AMP-activated protein kinase (AMPK) signaling pathway was assessed by Western blot. Gestational outcome was analyzed through comparing litter size and birth weight. Results: Oleuropein attenuated the elevated body weight of GDM mice, and efficiently reduced blood glucose, insulin and hepatic glycogen levels. Oxidative stress and inflammation were alleviated by oleuropein treatment. The AMPK signaling was activated by oleuropein in GDM mice. Gestational outcome was markedly improved by oleuropein treatment. Conclusions: Our study suggests that oleuropein is effective in alleviating symptoms of GDM and improving gestational outcome in the mouse model. This effect is achieved by attenuating oxidative stress and inflammation, which is mediated by the activation of the AMPK signaling pathway.

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Influences of olive leaf extract in the kidney of diabetic pregnant mice and their offspring

Cited by 6 publications

References 56 publications

The efficacy of oleuropein against non‐steroidal anti‐inflammatory drug induced toxicity in rat kidney

The efficacy of oleuropein against non‐steroidal anti‐inflammatory drug induced toxicity in rat kidney

Antioxidant, anti-inflammatory, and anti-fibrotic properties of olive leaf extract protect against L-arginine induced chronic pancreatitis in the adult male albino rat

Oleuropein alleviates gestational diabetes mellitus by activating AMPK signaling

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