Oleuropein alleviates gestational diabetes mellitus by activating AMPK signaling

Zhang, Zhiwei; Zhao, Hui; Wang, Aixia

doi:10.1530/ec-20-0466

Cited by 20 publications

(18 citation statements)

References 33 publications

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“…Oleuropein (OP), which exists in olive leaves, unripe olive fruits, olive branches, and olive oil, is a highly bioactive phenolic compound with various biological functions [ 7 , 8 ]. Previous studies have shown that OP consumption exerts therapeutic effects on the early stage of type 2 diabetes by repairing islet morphology, regulating insulin secretion, and improving glucose tolerance and insulin sensitivity [ 9 , 10 , 11 , 12 ]. However, the alleviating effects of OP on the advanced stage of type 2 diabetes and the regulatory effects of OP on intestinal microbes have not yet been investigated.…”

Section: Introductionmentioning

confidence: 99%

Oleuropein Ameliorates Advanced Stage of Type 2 Diabetes in db/db Mice by Regulating Gut Microbiota

et al. 2021

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Previous studies have reported the therapeutic effects of oleuropein (OP) consumption on the early stage of type 2 diabetes. However, the efficacy of OP on the advanced stage of type 2 diabetes has not been investigated, and the relationship between OP and intestinal flora has not been studied. Therefore, in this study, to explore the relieving effects of OP intake on the advanced stage of type 2 diabetes and the regulatory effects of OP on intestinal microbes, diabetic db/db mice (17-week-old) were treated with OP at the dose of 200 mg/kg for 15 weeks. We found that OP has a significant effect in decreasing fasting blood glucose levels, improving glucose tolerance, lowering the homeostasis model assessment–insulin resistance index, restoring histopathological features of tissues, and promoting hepatic protein kinase B activation in db/db mice. Notably, OP modulates gut microbiota at phylum level, increases the relative abundance of Verrucomicrobia and Deferribacteres, and decreases the relative abundance of Bacteroidetes. OP treatment increases the relative abundance of Akkermansia, as well as decreases the relative abundance of Prevotella, Odoribacter, Ruminococcus, and Parabacteroides at genus level. In conclusion, OP may ameliorate the advanced stage of type 2 diabetes through modulating the composition and function of gut microbiota. Our findings provide a promising therapeutic approach for the treatment of advanced stage type 2 diabetes.

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Section: Introductionmentioning

confidence: 99%

Oleuropein Ameliorates Advanced Stage of Type 2 Diabetes in db/db Mice by Regulating Gut Microbiota

et al. 2021

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“…Oleuropein treatment with the dose of 5 and 10 mg/kg decreases blood glucose, insulin, and hepatic glycogen and improves glucose tolerance, insulin resistance, and islet structure in gestational diabetes mellitus mice. These results are associated with AMPK signaling activation in the liver …”

Section: Beneficial Effects Of Oleuropein On Diabetes and Related Mol...mentioning

confidence: 81%

Efficacy and Mechanisms of Oleuropein in Mitigating Diabetes and Diabetes Complications

Zheng

Huang

Tong

2021

J. Agric. Food Chem.

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The global pandemic of diabetes and diabetes complications confers heavy pressure on public health. Novel antidiabetes strategies with negligible unwanted effects are urgently needed. Currently, the anti-hyperglycemic potential of plant-based functional ingredients has been explored to provide alternative strategies. As a kind of dietary bioactive compound, oleuropein has aroused the growing interest of researchers in diabetes and diabetes complications management. This review reveals the research progress of oleuropein in treating diabetes and diabetes complications and summarizes the molecular mechanisms involved in these beneficial effects of oleuropein. Oleuropein achieves amelioration of diabetes, the mechanisms of which include the modulation of insulin secretion, the repairment islet morphology, the activation of hepatic AMP-activated protein kinase singling, and the improvement of glucose tolerance and insulin resistance. Oleuropein also can relieve diabetes complications including diabetic nephropathy, diabetes cardiovascular complications, diabetic retinopathy, poor wound healing, diabetic neuropathy, and diabetic testicular dysfunction. Oleuropein reverses cell apoptosis, regenerates tissues, restores the histological organization, and decreases oxidative stress in treating diabetes complications. Taken together, oleuropein is a promising compound for diabetes and diabetes complications management and can be used as a nutraceutical to fight against these diseases.

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“…IL-1β promoted secretion of IL-8 and IL-6 and induced apoptosis of islet β cells, and IL-8 and IL-6 stimulated infiltration of inflammatory cells to aggravate the inflammatory injury [3]. Suppression of IL-6, IL-1β, and TNF-α ameliorated GDM [11]. Deletion of IRF2BP2 exacerbated high-fat diet-induced increases in IL-1β and TNF-α in mice [8].…”

Section: Discussionmentioning

confidence: 99%

IRF2BP2 attenuates gestational diabetes mellitus by activating AMPK signaling

Zhang¹,

Zhou²,

Yu³

et al. 2022

Trop. J. Pharm Res

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Purpose: To investigate the role of interferon regulatory factor 2 binding protein 2 (IRF2BP2) in gestational diabetes mellitus (GDM). Methods: Mice were injected intraperitoneally with streptozotocin to establish a model of GDM and then subjected to intraperitoneal glucose tolerance test (IPGTT) and intraperitoneal insulin tolerance test (IPITT) to determine glucose and insulin tolerances. Lipid metabolism was evaluated by enzyme-linked immunosorbent assay (ELISA). The histomorphology of pancreatic islets was assessed by hematoxylin and eosin staining. Results: IRF2BP2 was downregulated in pancreatic tissues of mice with GDM (p < 0.001). Mice in GDM group showed higher blood glucose levels than those in normal pregnancy group. However, overexpression of IRF2BP2 reduced glucose and insulin levels in mice with GDM. Overexpression of IRF2BP2 increased the level of high-density lipoprotein (HDL) and reduced triglyceride (TG), total cholesterol (TC), and low-density lipoprotein (LDL) levels in mice with GDM (p < 0.001). The histopathological changes in the islets of mice with GDM were also ameliorated by overexpression of IRF2BP2. Overexpression of IRF2BP2 reduced IL-6, IL-1β, and TNF-α levels and increased protein expression of p-AMPK in mice with GDM. Conclusion: IRF2BP2 ameliorates the outcomes of GDM and suppressed inflammation in mice with GDM through activation of AMPK signaling. Thus, IRF2BP2 is a potential therapeutic strategy for the management of GDM. Keywords: IRF2BP2; inflammation; gestational diabetes mellitus; AMPK; mice; insulin tolerance

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Oleuropein alleviates gestational diabetes mellitus by activating AMPK signaling

Cited by 20 publications

References 33 publications

Oleuropein Ameliorates Advanced Stage of Type 2 Diabetes in db/db Mice by Regulating Gut Microbiota

Oleuropein Ameliorates Advanced Stage of Type 2 Diabetes in db/db Mice by Regulating Gut Microbiota

Efficacy and Mechanisms of Oleuropein in Mitigating Diabetes and Diabetes Complications

IRF2BP2 attenuates gestational diabetes mellitus by activating AMPK signaling

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