Older adults with epilepsy demonstrate cognitive impairments compared with patients with amnestic mild cognitive impairment

Griffith, H. Randall; Martin, Roy C.; Bambara, Jennifer K.; Marson, Daniel C.; Faught, Edward

doi:10.1016/j.yebeh.2005.09.004

Cited by 82 publications

(65 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In this study duration of seizure free interval did not have any statistical significance, which is in contrast to earlier studies. 5,6,7,8,49 The present investigation has several limitations and certain relative merits. The samples as well as the control are not representative of the general population.…”

Section: Discussionmentioning

confidence: 92%

“…47 Patients with chronic partial epilepsy demonstrated deficits on overall cognition and verbal memory that generally are not progressive. 48, 49 Mirsky and co-workers studied idiopathic generalized epilepsy with JME and found that both subgroups of patients were found to be impaired in visual and auditory sustained attention. 5 Patients with idiopathic generalized epilepsy performed significantly poorer in non-verbal and verbal attention, verbal learning and memory, word fluency, and controlled sequential fine motor responses excluding non-verbal memory.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Cognitive Impairment in Epilepsy: A Clinical Study

A¹,

Mathai²

2017

IOSR JDMS

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Cognitive Impairment in Epilepsy: A Clinical Study

A¹,

Mathai²

2017

IOSR JDMS

View full text Add to dashboard Cite

“…The investigator did not intervene and rather simply "observed" and assessed the strength of the relationship between a risk factor and disease variables [8]. In fact, casecontrol study usually identifies subjects by outcome status at the outset of the investigation.…”

Section: Methodsmentioning

confidence: 99%

Left Temporal Neuronal Hyperexitability as a Predictor of Mild Cognitive Impairment: Clinical and Neurophysiological Study

Panebianco¹,

Perrone²,

Pavone³

2016

J Neurol Neurosci

View full text Add to dashboard Cite

Introduction: Mild cognitive impairment (MCI) usually is the early stage of dementia which is defined as decreasing in mental abilities such cognition, memory, and speech not too severe to interfere daily activities. MCI diagnosis is rather hard and usually assumed as normal consequences of aging. Diagnosis is usually performed through a combination of extensive testing and eliminations of other possible causes. "Seizures" or neuronal hyperexitability in the temporal lobe, transiently impair cognition and steadily damage hippocampal circuitry, leading to progressive memory loss.

show abstract

“…16 Algumas pesquisas têm sido realizadas com o intuito de caracterizar a extensão e a natureza do comprometimento cognitivo decorrente da epilepsia crônica. Este declínio é evidente em múltiplos domínios cognitivos, 5,6,17 mas parece ser mais intenso e frequente nos domínios da memória verbal, atenção e velocidade psicomotora. 17 A duração da epilepsia parece ser o maior fator preditivo do comprometimento cognitivo.…”

Section: Introductionunclassified

“…17 A duração da epilepsia parece ser o maior fator preditivo do comprometimento cognitivo. 5,17 Por outro lado, a demência predispõe o paciente a apresentar crises epilépticas como consequência do desenvolvimento de lesões neurológicas, algumas vezes epileptogênicas. 4,7,9,14 A frequência de epilepsia associada à demência pode variar conforme a etiologia, embora ainda haja poucos dados a este respeito na literatura.…”

Section: Introductionunclassified

Epilepsia e demência em uma amostra de pacientes idosos acompanhados em serviço terciário

Almeida

Fonseca

Santos

et al. 2009

J. epilepsy clin. neurophysiol.

View full text Add to dashboard Cite

RESumo objetivo: Determinar a freqüência de epilepsia em uma amostra ambulatorial de pacientes idosos com demência e analisar possível associação da epilepsia a uma causa específica de demência. metodologia: Estudo retrospectivo com dados de 135 pacientes com demência acompanhados em ambulatório de Neurologia Cognitiva, no período de setembro de 2006 a novembro de 2007. Foi realizado levantamento de dados clínicos, laboratoriais, de neuroimagem e de eletroencefalograma. As etiologias das demências foram definidas de acordo com critérios diagnósticos específicos, a partir do quadro clínico, exame neurológico, avaliação neuropsicológica, exames laboratoriais e de neuroimagem. Resultados: A freqüência de epilepsia foi 12%, sendo maior na demência mista (21,4%), seguida pela demência frontotemporal (18,6%), demência vascular (15,4%) e doença de Alzheimer (10,8%). No entanto, nenhuma diferença estatística foi observada entre essas freqüências (p = 0,817). Observou-se que 87,5% dos pacientes iniciaram o quadro de epilepsia na vida adulta, sendo que em 84,6% destes pacientes, o desenvolvimento de epilepsia foi posterior ao início do declínio cognitivo. Os tipos de crise mais comuns foram a tônico-clônico generalizada (43%) e a parcial complexa (38%). Conclusão: Apesar da freqüência de epilepsia ser variável entre os diversos tipos de demência, essa variabilidade não foi suficiente para demonstrar diferença estatística. unitermos: Epilepsia, demência, idosos. AbSTRACTEpilepsy and dementia in a sample of elderly patients followed at a tertiary outpatient clinic objectives: To determine the frequency of epilepsy in a sample of elderly outpatients with dementia and to evaluate whether epilepsy was more associated with a specific dementia etiology. methodology: Data from 135 patients with dementia were retrospectively analyzed in a Cognitive Neurology Outpatient Unit. We analyzed data from clinical evaluation, neurological examination, neuropsychological testing, laboratory and neuroimaging findings, and electroencephalogram, whenever available. Etiologies of dementia were defined according to specific diagnostic criteria. Results: Epilepsy was present in 12% of the cases, being more frequent in mixed dementia (21.4%), followed by frontotemporal dementia (18.6%), vascular dementia (15.4%) and Alzheimer's disease (10.8%). However, the rates of epilepsy across the different dementia etiologies were not significantly different (p = 0.817). Overall, 87.5% of patients started the epilepsy during adulthood, and in 84.6% of these individuals, epilepsy started after the emergence of cognitive decline. The most common types of seizures were generalized tonic-clonic (43%) and complex partial (38%). Conclusion: Although epilepsy occurred rather commonly in this sample of patients with dementia, no significant difference was found among the distinct etiologies.

show abstract

Older adults with epilepsy demonstrate cognitive impairments compared with patients with amnestic mild cognitive impairment

Cited by 82 publications

References 33 publications

Cognitive Impairment in Epilepsy: A Clinical Study

Cognitive Impairment in Epilepsy: A Clinical Study

Left Temporal Neuronal Hyperexitability as a Predictor of Mild Cognitive Impairment: Clinical and Neurophysiological Study

Epilepsia e demência em uma amostra de pacientes idosos acompanhados em serviço terciário

Contact Info

Product

Resources

About