Left Temporal Neuronal Hyperexitability as a Predictor of Mild Cognitive Impairment: Clinical and Neurophysiological Study

Abstract

Introduction: Mild cognitive impairment (MCI) usually is the early stage of dementia which is defined as decreasing in mental abilities such cognition, memory, and speech not too severe to interfere daily activities. MCI diagnosis is rather hard and usually assumed as normal consequences of aging. Diagnosis is usually performed through a combination of extensive testing and eliminations of other possible causes. "Seizures" or neuronal hyperexitability in the temporal lobe, transiently impair cognition and steadily damage hippocampal circuitry, leading to progressive memory loss.