Oil mixes omega 9, 6 and 3, enriched with seaweed, promoted reduction of thermal burned modulating NF-kB and Ki-67

Abstract

PURPOSE:To examine the effects of the oil mixes (ω-9, ω-6 and ω-3) in rats subjected to thermal burn. It was also aimed to assess whether the sources of ω3 would interfere with the effect of such mixes on the thermal injury. METHODS:Thirty-six rats distributed into five groups: burned + water, burned + isolipid mix, burned + oil mix 1 (ALA), burned + oil mix 2 (ALA + EPA + DHA of fish) and burned + oil mix 3 (ALA + DHA from seaweed). The thermal injury was involving total thickness of skin. After the burns animals received the oil mixes for seven days. The lesions were evaluated by immunohistochemistry.RESULTS: Animals receiving mix 3 showed a smaller extension of the thermal injury as compared to those that were supplemented with other oils mixes. Expression of Ki-67 in the receiving Mix 3 increased as compared to all the other groups. Animals supplemented with mix 3 were able to inhibit NF-κB in injured tissue. CONCLUSION:Rats received oil mix in which the source of ω3 (ALA+DHA of seaweed) showed inhibition of NF-κB, increase in cell proliferation, and reduction the extension of thermal lesion.Key words: Burn. Fatty Acids. Seaweed. Docosahexenoic Acid. alpha-Linolenic Acid. Rats.Oil mixes omega 9, 6 and 3, enriched with seaweed, promoted reduction of thermal burned modulating

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“…Campelo et al (2015), demonstrou o aumento da proliferação celular e a redução da área de lesões térmicas tratadas com misturas de ácidos graxos, em sete dias de tratamento. Entretanto, o estudo de Campelo et al (2015) fez a administração dos tratamentos via oral, diferindo da forma proposta neste estudo, possibilitando a ação destes compostos por outras vias, que não a tópica local.…”