Odor and taste aversions conditioned in anesthetized rats.

Bermúdez‐Rattoni, Federico; Forthman, Debra L.; Sánchez, Marco A.; Pérez, J.L. Beato; García, John

doi:10.1037//0735-7044.102.5.726

Cited by 19 publications

(1 citation statement)

References 22 publications

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“…The conditioned taste aversion is an excellent task with a long delay between the CS (taste) and US (poisoning). However, since animals can also be unconscious during the US and still form an association [28,29], the conditioned taste aversion might be considered an implicit memory where no recollection is needed for its expression. Novel object recognition tasks [30][31][32] were developed specifically to test episodic-like memory; however, the tasks received criticism that they rely more on a sense of familiarity rather than on recollection [33].…”

Section: Discussionmentioning

confidence: 99%

Incidental temporal binding in rats: A novel behavioral task

et al. 2023

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We designed a behavioral task called One-Trial Trace Escape Reaction (OTTER), in which rats incidentally associate two temporally discontinuous stimuli: a neutral acoustic cue (CS) with an aversive stimulus (US) which occurs two seconds later (CS-2s-US sequence). Rats are first habituated to two similar environmental contexts (A and B), each consisting of an interconnected dark and light chamber. Next, rats experience the CS-2s-US sequence in the dark chamber of one of the contexts (either A or B); the US is terminated immediately after a rat escapes into the light chamber. The CS-2s-US sequence is presented only once to ensure the incidental acquisition of the association. The recall is tested 24 h later when rats are presented with only the CS in the alternate context (B or A), and their behavioral response is observed. Our results show that 59% of the rats responded to the CS by escaping to the light chamber, although they experienced only one CS-2s-US pairing. The OTTER task offers a flexible high throughput tool to study memory acquired incidentally after a single experience. Incidental one-trial acquisition of association between temporally discontinuous events may be one of the essential components of episodic memory formation.

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