Oculo-renal Disorders in Infectious Diseases

Izzedine, Hassane; Buhăescu, Irina; Bodaghi, Bahram; Martinez, Valérie; Caumes, Éric; LeHoang, Phuc; Deray, Gilbert

doi:10.1007/s10792-005-4833-7

Cited by 6 publications

(3 citation statements)

References 124 publications

(102 reference statements)

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“…Renal diseases accompanied by ocular diseases are not rare. They often occur with autoimmune diseases [15], infectious diseases [16], hereditary diseases [17], or metabolic diseases (such as diabetic retinopathy). The most common ocular complications caused by NS are cataracts and glaucoma induced by glucocorticoids [18].…”

Section: Discussionmentioning

confidence: 99%

Retinal and choroidal thickness in paediatric patients with hypoalbuminaemia caused by nephrotic syndrome

Zhang

Kang

et al. 2019

BMC Ophthalmol

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BackgroundA study was conducted to evaluate the choroidal thickness (CT) and retinal thickness (RT) in paediatric patients with hypoalbuminaemia caused by nephrotic syndrome (NS). We also studied the correlation between the subfoveal choroidal thickness (SFCT) and serum protein concentration.MethodsThis was a cross-sectional study. Fifty-one paediatric patients with hypoalbuminaemia caused by NS and 41 normal subjects were included in the study. Enhanced depth imaging optical coherence tomography (EDI-OCT) was performed to measure the RT and CT. The RT and CT were measured manually at intervals of 0.5 mm along a horizontal line through the macular fovea between 2.5 mm nasal and 2.5 mm temporal to the fovea. Clinical data including measurements of serum proteins were obtained.ResultsThe mean RTs at the T2.5, T2, N1.5, N2, and N2.5 locations and the average macular horizontal RT were slightly greater in the NS group than those in the control group. The mean CTs at all locations were significantly greater in the NS group than those in the control group; the difference was most significant at the fovea (373.8 ± 74.9 μm vs. 280.2 ± 57.1; p < 0.001). The SFCT in patients with NS was correlated with age (r = − 0.307, p = 0.003), body height (r = − 0.320, p = 0.022), body weight (r = − 0.343, p = 0.014), axial length (AL, r = − 0.237, p = 0.023), total protein (TP, r = − 0.302, p = 0.031), albumin (ALB, r = − 0.285, p = 0.042), prealbumin (PA, r = − 0.303, p = 0.033) and 24-h urine volume (UV, r = − 0.298, p = 0.034). Multiple linear regression analysis showed that the TP concentration and body weight had the highest correlation with the SFCT (R2 = 0.220, p < 0.05).ConclusionsThe macular RT is slightly increased and the macular CT is significantly increased in paediatric patients with hypoalbuminaemia caused by NS, indicating fluid accumulation in the retina and choroid. There is a negative correlation between the SFCT and serum TP concentration. Thus, the serum TP concentration is an important indicator of CT in patients with hypoalbuminaemia.

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Section: Discussionmentioning

confidence: 99%

Retinal and choroidal thickness in paediatric patients with hypoalbuminaemia caused by nephrotic syndrome

Zhang

Kang

et al. 2019

BMC Ophthalmol

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“…Several hypotheses have been suggested regarding the cause of TINU syndrome, and these include genetic predisposition, hypersensitivity to drugs, and infection. [14][15][16] For example, a very strong association between the HLA-DRB1 and HLA-DQA1 genes and biopsy-confirmed TINU syndrome has been confirmed by independent groups. [17][18][19] In addition, the use of antibiotics that are often prescribed to treat respiratory tract infections and/or the use of nonsteroidal antiinflammatory drugs is associated with AIN but the role in pathogenesis of TINU syndrome is not elucidated yet.…”

Section: Discussionmentioning

confidence: 99%

The Value of Measuring Urinary β2-Microglobulin and Serum Creatinine for Detecting Tubulointerstitial Nephritis and Uveitis Syndrome in Young Patients With Uveitis

et al. 2015

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IMPORTANCE Tubulointerstitial nephritis and uveitis (TINU) syndrome is characterized by tubulointerstitial and ocular inflammation. Thus far, the value of noninvasive diagnostic tests is not known.OBJECTIVE To determine whether urinary β2-microglobulin (β2M), urinary protein, and serum creatinine have predictive value for detecting TINU syndrome in young patients with uveitis. DESIGN, SETTING, AND PARTICIPANTSThis prospective cohort study was conducted July 2010 through February 2013 at a tertiary care referral center in Utrecht, the Netherlands. Forty-five consecutive new patients with uveitis aged 22 years or younger were enrolled.EXPOSURES Urinary β2M, urinary protein, and serum creatinine were measured prospectively, and the estimated glomerular filtration rate was calculated. MAIN OUTCOMES AND MEASURESA post hoc analysis was performed to determine whether urinary β2M, urinary protein, serum creatinine, estimated glomerular filtration rate, and/or pyuria were correlated with definitive and probable cases of TINU syndrome.RESULTS Eighteen of the 45 patients (40%) in our cohort had elevated urinary β2M levels, and 10 patients (22%) had elevated serum creatinine levels. Twenty of 43 patients (47%) had proteinuria. Eight of the 45 patients were diagnosed by a pediatric nephrologist as having renal dysfunction that suggested acute interstitial nephritis. Of these 8 patients, 2 were definitively diagnosed as having TINU syndrome (confirmed by renal biopsy). After excluding other causes of renal dysfunction, the remaining 6 patients with uveitis and renal dysfunction fulfilled the criteria of probable TINU syndrome. The 8 patients with definitive or probable TINU syndrome had higher urinary β2M levels than patients with normal renal function (median β2M, 1.95 mg/L; 95% CI, 1.26-5.16 mg/L vs 0.20 mg/L; 95% CI, 0.19-0.21 mg/L; P < .001; Mann-Whitney U test). Our analysis revealed that the positive predictive value of increased β2M combined with increased serum creatinine was 100% for detecting definitive and/or probable TINU syndrome.CONCLUSIONS AND RELEVANCE These data suggest that urinary β2M and serum creatinine levels are sensitive and relatively simple diagnostic screening tools for detecting renal dysfunction to diagnose TINU syndrome in young patients with uveitis similar to those evaluated in this study.

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“…It most often occurs in patients with systemic conditions (infectious or vasculitic) (1,2) or genetic diseases (3). However, the occurrence of ocular abnormalities directly related to nephrotic syndrome (NS) is rarely reported (4)(5)(6).…”

Section: Introductionmentioning

confidence: 99%

Bilateral Serous Retinal Detachment as a Presenting Sign of Nephrotic Syndrome

et al. 2014

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We herein present a case of bilateral serous retinal detachment (SRD) as a presenting sign of nephrotic syndrome (NS). A 48-year-old man complained of decreased vision related to bilateral SRD. Laboratory tests revealed NS (serum albumin, 17 g/L: proteinuria, 15.40 g over 24 hours). Following treatment for edema with a diuretic, the bilateral SRD resolved completely, with a full recovery of the patient's vision. A kidney biopsy disclosed glomerular and vascular amyloid deposits; the amyloid stained strongly with anti-λ antiserum. Therefore, a diagnosis of AL amyloidosis was made. The sudden appearance of SRD should raise suspicion of a diagnosis of NS. Prompt recognition of this symptom is important for early treatment and restoration of the visual function.

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Oculo-renal Disorders in Infectious Diseases

Abstract: The oculorenal manifestations of infectious diseases may be flagrant or subtle. Awareness of the signs and symptoms of infections allows early recognition and prompt, appropriate management. The clinical presentation and relative frequency of those manifestations are reviewed.

Cited by 6 publications

References 124 publications

Retinal and choroidal thickness in paediatric patients with hypoalbuminaemia caused by nephrotic syndrome

Retinal and choroidal thickness in paediatric patients with hypoalbuminaemia caused by nephrotic syndrome

The Value of Measuring Urinary β2-Microglobulin and Serum Creatinine for Detecting Tubulointerstitial Nephritis and Uveitis Syndrome in Young Patients With Uveitis

Bilateral Serous Retinal Detachment as a Presenting Sign of Nephrotic Syndrome

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