“…In addition to TINU, the main diagnoses to consider in children and adolescents with both uveitis and renal disease include systemic lupus erythematosus, sarcoidosis, granulomatosis with polyangiitis, and Sjögren syndrome. 60 Petrushkin et al 45 provided a systematic overview of the pathogenesis, clinical features, and treatment of familial Mediterranean fever (FMF), a recessively inherited, multisystem, autoinflammatory disease that affects children from the Mediterranean basinmost notably those with Turkish, Armenian, Arabic, and Sephardic Jewish ancestry. Genetic polymorphisms associated with FMF occur in the MEFV (Mediterranean fever) gene, located on chromosome 16 and now known to code for pyrin-a 781 amino acid protein with incompletely understood roles in the regulation of the cellular cytoskeleton, apoptosis, and activation of intracellular pathways involved in inflammatory cytokine signaling.…”