Ocular tuberculosis – A closer look to an increasing reality

Teixeira-Lopes, Francisca; Alfarroba, Sara; Dinis, Ana; Gomes, Mara; Tavares, Ana

doi:10.1016/j.pulmoe.2018.02.006

Cited by 18 publications

(27 citation statements)

References 13 publications

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“…Because of the paucibacillary nature of the organism, even the samples collected do not always yield results, even with PCR testing. 4 This problem is compounded by the fact that OTB can present with symptoms similar to other ocular diseases. OTB may be categorised into TB scleritis and TB uveitis (TBU).…”

Section: Introductionmentioning

confidence: 99%

Role of interferon gamma release assay in the diagnosis and management ofMycobacterium tuberculosis-associated uveitis: a review

2021

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Tuberculosis (TB)-associated uveitis is a common cause of infectious uveitis in the developing world. Diagnosis of TB uveitis remains a challenge. The role of interferon gamma release assays (IGRAs) is uncertain. Herein we summarise the available literature on the utility of IGRAs in the diagnosis and management of TB uveitis. We searched PubMed database from 1 August 2010 to 31 July 2020 using the following keywords alone and in combination: ‘interferon-gamma release assay’, ‘QuantiFERON’, ‘T-SPOT.TB’, ‘TB uveitis’, ‘serpiginous like choroiditis’, ‘tuberculoma’, ‘TB vasculitis’, ‘TB panuveitis’ and ‘ocular tuberculosis’. Data from 58 relevant studies were collated. The review is focused on currently marketed versions of IGRA tests: QuantiFERON-TB Gold In-Tube assay, QuantiFERON-TB Gold Plus assay (QFT-Plus) and T-SPOT.TB. We found limited evidence regarding the diagnostic utility of IGRA in patients with uveitis. No study was identified evaluating the newer QFT test—the QFT-Plus—in patients with uveitis. Similarly, there is lack of data directly comparing QFT-Plus with T-SPOT.TB specifically for the diagnosis of TB uveitis.

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Section: Introductionmentioning

confidence: 99%

Role of interferon gamma release assay in the diagnosis and management ofMycobacterium tuberculosis-associated uveitis: a review

2021

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“…Based on the current diagnostic criteria, ocular TB can be categorized as confirmed, probable, and possible (Gupta et al, 2015;Teixeira-Lopes et al, 2018). The presence of Mtb from ocular samples is mandatory for the diagnosis of confirmed TB (Agrawal et al, 2020;Gupta et al, 2015;Teixeira-Lopes et al, 2018). Polymerase chain reaction (PCR) is considered a rapid and easy method to detect the cause of uveitis due to infection, including Mtb.…”

Section: Introductionmentioning

confidence: 99%

The diagnostic value of polymerase chain reaction for ocular tuberculosis diagnosis in relation to antitubercular therapy response: a meta-analysis

Nora

Putera

Khalisha

et al. 2021

International Journal of Infectious Diseases

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“…OTB can develop as a primary infection (with the eye as the entrance point) or due to hematogenous dissemination [4].…”

Section: Introductionmentioning

confidence: 99%

A review on Ocular Tuberculosis: Epidemiology, Clinical Features and Treatment

Singh

Bewtra

Kher

2021

JPRI

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Background: globalization and migration movements are intimately linked to the expansion of tuberculosis. Tuberculosis has also been the primary cause of death in patients with HIV infection and the leading cause of death related to antibiotic resistance. Tuberculosis may affect any part of the uveal tract. T cell activity is of significance in Tuberculous infection. The phagocytosis of bazillion by macrophage is a significant factor in limiting the spread of infection. However, in patients who have had a previous tuberculous infection, the cell-mediated response is also associated with tissue damage due to the direct effect of sensitized T lymphocytes on the cell containing the ingested bacilli. Ocular tuberculosis is extrapulmonary tuberculosis with a wide range of symptoms. Tuberculosis is considered to infect the lungs of the patients in 80% of cases, and 20% of cases affect other organs like the eye. Ocular tuberculosis is an infectious disease with bacterial etiology that has a chronic case with a poor prognosis. Even the most effective treatment can cause vision loss, and clinical recovery is not always permanent. Ocular tuberculosis frequently results in permanent impairment, lowering patients' quality of life. Objective: This article reports the various known presentations of ocular TB and reviews essential epidemiology, diagnosis, and treatment elements. Methodology: The present study is a systematic review of literature searched from electronic databases and highly reputed websites like PubMed, researchgate, Elsevier, etc. Medical Subject Headings (MeSH) and the trial registry in the English language. Conclusion: Ocular tuberculosis (OTB) diagnosis and treatment are difficult to come by. The disease's current uncertainty is due to mixed ocular tissue involvement, a lack of consensus on best practice diagnostic tests, and global variations in medical management. The present evaluation intends to provide an update on OTB's recent progress.

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Ocular tuberculosis – A closer look to an increasing reality

Cited by 18 publications

References 13 publications

Role of interferon gamma release assay in the diagnosis and management ofMycobacterium tuberculosis-associated uveitis: a review

Role of interferon gamma release assay in the diagnosis and management ofMycobacterium tuberculosis-associated uveitis: a review

The diagnostic value of polymerase chain reaction for ocular tuberculosis diagnosis in relation to antitubercular therapy response: a meta-analysis

A review on Ocular Tuberculosis: Epidemiology, Clinical Features and Treatment

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