Ocular disorders in adult leukemia patients in Nigeria

Abstract

Context:Leukemias may present with, or be associated with ocular disorders.Aims:To determine the rates of ophthalmic disorders in adult patients with leukemia.Settings and Design:A prospective study of ocular disorders in adult patients with leukemia at the University of Benin Teaching Hospital, Benin City, Nigeria, between July 2004 and June 2008 was conducted.Methods and Materials:The patients were interviewed and examined by the authors and the ocular findings were recorded. Statistical analysis was performed using Instat GraphPad™ v2.05a statistical package software. The means, standard deviation, and the Kruskal-Wallis non parametric test were performed.Results:Forty-seven patients with leukemias were seen. Nineteen patients (40.4%) had CLL, 14(29.8%) had CML, 9(19.1%) had AML and 5(10.6%) had ALL. Seven patients (14.9%) had ocular disorders due to leukemia. The ocular disorders due to the leukemia were proptosis in two patients (4.3%), retinopathy in one patient (2.1%), conjunctival infiltration in one patient (2.1%), periorbital edema in one patient (2.1%), retinal detachment in one patient (2.1%), and subconjunctival hemorrhage in one patient (2.1%). There was no significant difference in rate of the ocular disorders in the various types of leukemia (Kruskal-Wallis KW= 4.019; corrected for ties. P=0.2595). One patient (2.1%) was blind from bilateral exudative retinal detachment while 1 patient (2.1%) had monocular blindness from mature cataract.Conclusions:Ophthalmic disorders that are potentially blinding occur in leukemias. Ophthalmic evaluation is needed in these patients for early identification and treatment of blinding conditions.

Ophthalmic Manifestations In Patients of Acute Leukaemia Presenting to A Tertiary Care Centre In Western Rajasthan

“…9 Subjects with AML (63.04%) had higher incidence of ocular manifestation than ALL patients (50%). This was similar to studies by Reddy et al 11 and Omoti et al 13 ( Figure 3 & 4). There were 44 adults and 66 children who were examined.…”

Ophthalmic manifestations of acute and chronic leukemias presenting to a tertiary care center in India

“…[ 12 16 17 21 ] Acute leukemia patients in this study had significantly more ocular manifestations than chronic patients (51.9% vs. 25%) Fisher exact t -test, P – 0.01467. This was similar to the findings of Reddy et al .,[ 12 ] Omoti et al .,[ 22 ] Kincaid and Green,[ 2 ] and Leonardy et al . [ 3 ] However, studies by Eze et al .…”

“…[ 12 ] and Omoti et al . [ 22 ] These details are given in Table 3 . In the acute group, there was a significant difference (Chi-square 2.85, P = 0.045) between adults 29/48 (60.4%) and 6/20 (30%) children with respect to ocular manifestations; adults had a significant association with ocular manifestations.…”

Ophthalmic Manifestations in Recently Diagnosed Childhood Leukemia

“…Ophthalmic manifestations of the leukemias have been described in various studies and almost every ocular structure has been found to be involved (3, 7–8–9). The reported prevalence of ocular involvement in patients with leukemia including both adults and children varies from 9% to 77.8% from different parts of the world (2, 5, 6, 9).…”