Ophthalmic Manifestations in Recently Diagnosed Childhood Leukemia

Bitirgen, Gülfidan; Belviranlı, Selman; Çalışkan, Ümran; Tokgöz, Hüseyin; Özkağnıcı, Ahmet; Zengin, Nazmi

doi:10.5301/ejo.5000647

Cited by 28 publications

(26 citation statements)

References 14 publications

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“…Majority of patients included in our study were males (56.7%). This pattern of male majority in patients with acute leukemia is comparable to that reported in the studies of Bitirgen et al (60%) [12], Koshy et al (63.5%) [10], Gawai et al (61%) [5], and Dhasmana et al (64.7%) [7]. This trend points to the epidemiological higher prevalence of acute leukemia in the male population.…”

Section: Discussionsupporting

confidence: 87%

Ophthalmic Manifestations of Acute Leukemia

Hafeez

Ali

Najib

et al. 2019

Cureus

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IntroductionOcular involvement in leukemia may occur because of direct leukemic infiltration or because of secondary ophthalmic involvement as a result of abnormalities related to blood like anemia, thrombocytopenia, and leukocytosis. In some patients with leukemia, ophthalmic signs can precede the systemic features and can help in early diagnosis of systemic leukemia. Due to the scarcity of data on this topic from Pakistan, we conducted this study to determine the pattern of ocular involvement in patients with leukemia presenting in our settings.MethodsThis cross-sectional study was conducted in a tertiary care hospital of Pakistan over a period of one year. The study comprised of both newly diagnosed and follow-up patients of acute leukemia of age more than 15 years. Patients underwent detailed ophthalmic anterior and dilated posterior segment examination. Patient’s demographic profile, type of leukemia, chemotherapy status, and hematologic findings were also documented.ResultsThere were 97 leukemic patients in the study with 55 (56.7%) males and 42 (43.3%) females. Various ophthalmic manifestations were observed in 47 (48.45%) patients. Forty-two (43.3%) were diagnosed cases with acute lymphocytic leukemia (ALL) and 55 (56.7%) suffered from acute myelogenous leukemia (AML). Ophthalmic manifestations were present in 29 patients of AML (52.7%) and 18 patients of ALL (42.85%). Ocular involvement was significantly more common in newly diagnosed (n=32) as compared with follow-up patients (n=15) (p-value = 0.032). Posterior segment (n=48) was the most common site of ocular involvement (n=48, 49.5%) with retinal hemorrhages seen in 40 patients (41.2%) and papilloedema in seven cases (7.2%). Thirty-three (70.2%) out of 47 patients with ophthalmic manifestations were asymptomatic while 14 (29.8%) had ocular symptoms at the time of initial presentation.ConclusionOphthalmic manifestations were present in about half of the patients with leukemia. Ocular involvement was more prevalent in newly diagnosed cases and in patients with AML.

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Section: Discussionsupporting

confidence: 87%

Ophthalmic Manifestations of Acute Leukemia

Hafeez

Ali

Najib

et al. 2019

Cureus

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“…The present results in children ALL cases were agreement with (9), That the ALL is the mostly common of the cancer between the children and, the greatest common causes of death by cancer before twenty years of age (10) .…”

Section: Discussionsupporting

confidence: 90%

Evaluation Study of Different Techniques in Diagnosis of Acute Leukemia in Adults and Children Patients

2020

IJFMT

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Cytomorphology and cytochemistry are combined with immunophenotype by flow cytometry (FCM) to diagnosis and management the acute leukemia. The present study was designed to compare between the cytomorphology, cytochemistry and immunophenotype by flow cytometry at diagnosis and classification of acute leukemia to suggest a number of antibodies that can be adopted in the diagnosis by flow cytometry. The study included (160) cases were newly diagnosed (100 adults, 60 children). Morphological analysis was depended on peripheral blood smears examination by Leishman stain, cytochemical analysis with PAS and SBB stains and immunophenotype analysis used multiparameter. the results of this study shown that 60% of adult cases were AML, and 40% ALL. The mean age of adults was 48.45 years for AML cases and was 32.59 years for ALL adult cases. In children AML the mean age was 5.23 years and was 6.44 years in children ALL cases. Our Conclusion Also that the B.ALL was more commonly than T.ALL in both adults and children cases. Immunophenotypic detection by flow cytometry recorded (100%) successfully diagnosis in ALL cases, but it was successfully in (75%) of detected the subtypes of AML cases.

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“…De acordo com a linhagem divide-se em: leucemia mieloide aguda (mieloblastos ou promielócitos) ou leucemia linfocítica aguda (linfoblastos). (2) A Leucemia infantil é caracterizada por se apresentar em 95 % dos casos na forma de Leucemia Linfoblástica Aguda e é responsável por aproximadamente 70% dos casos de Leucemia em crianças. (2) O envolvimento ocular aparece mais frequentemente na leucemia mieloide do que na leucemia linfoide e é mais frequente em adultos do que em crianças.…”

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Retinal changes in patients with acute lymphocytic leukemia (all): discussion of topic from a case report

Barcelos¹,

Roisman²,

Tochetto³

et al. 2021

Revista Brasileira De Oftalmologia

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A Leucemia Linfocitica Aguda (LLA) é uma doença caracterizada por uma alta taxa de sobrevida, porém o número absoluto de crianças que morrem por ela representa uma grande parcela dos casos de óbitos infantis por câncer. A morbidade decorrente de seu tratamento pode deixar sequelas em pessoas com grande expectativa de vida, tornando-se extremamente necessário o entendimento da patogênese desta doença, possibilitando o desenvolvimento de novos tratamentos e diminuição de sequelas provocadas pela doença. O diagnóstico precoce é importante para se evitar complicações oculares que possam levar a baixa de acuidade visual em longo prazo e para avaliação de recaídas de tratamento sendo determinante no direcionamento de condutas.

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Ophthalmic Manifestations in Recently Diagnosed Childhood Leukemia

Abstract: Various ocular signs may be present at the time of diagnosis in childhood leukemia, even in patients without any symptoms. Routine ophthalmic examination should be performed in recently diagnosed children with leukemia.

Cited by 28 publications

References 14 publications

Ophthalmic Manifestations of Acute Leukemia

Ophthalmic Manifestations of Acute Leukemia

Evaluation Study of Different Techniques in Diagnosis of Acute Leukemia in Adults and Children Patients

Retinal changes in patients with acute lymphocytic leukemia (all): discussion of topic from a case report

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