Ocular and systemic features of Peters' anomaly

Abstract

Peters' anomaly accompanying corneolenticular adhesion and/or other ocular anomalies should be evaluated for the presence of systemic anomalies.

Strabismus and Amblyopia in Bilateral Peters Anomaly

“…In our study, systemic abnormalities were found in 31% of patients and consisted of facial deformities, central nervous system malformations and developmental delay, among others (Table 1). Our findings are in agreement with a previous report by Ozeki et al, 18 who found that systemic abnormalities occurred in 35% of patients with Peters anomaly. In addition, in another study, Mayer 19 found that one third of patients with Peters anomaly had systemic malformations.…”

Suppression of Lens Stalk Cell Apoptosis by Hyaluronic Acid Leads to Faulty Separation of the Lens Vesicle

“…We demonstrated in the previous studies by the method of experimental teratology that faulty closure of the embryonic ®ssure often accompanied faulty separation of the lens vesicle and that both ocular anomalies were caused by the common mechanism, abnormal migration of neural crest cells (Shirai, 1991;Ozeki and Shirai, 1998). In addition, we recently demonstrated clinically that Peters' anomaly caused by faulty separation of the lens vesicle not infrequently coexisted with uveal coloboma caused by faulty closure of the embryonic ®ssure (Ozeki et al, 2000). Therefore, we inferred that these two eyes exhibited both faulty closure of the embryonic ®ssure and presumed faulty separation of the lens vesicle.…”

Peters anomaly in cri-du-chat syndrome

“…4 In a retrospective review of 37 patients with Peters anomaly, 9 displayed corneal staphyloma. 5 Iridolenticulocorneal adhesions are common. 5, 6 We believe the partial absence of Descemet's membrane, and the iridolenticulocorneal adhesions are consistent with a diagnosis of Peters anomaly in our patient.…”