Strabismus and Amblyopia in Bilateral Peters Anomaly

Najjar, Dany M.; Christiansen, Stephen P.; Bothun, Erick D.; Summers, C. Gail

doi:10.1016/j.jaapos.2006.01.006

Cited by 26 publications

(20 citation statements)

References 22 publications

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“…Finally, the mean follow-up per patient was shorter in all of these studies than our series. [5][6][7][8][9][10][11][12][13][14][15][16][17][18][20][21][22][23][24][25][26]28 The visual outcomes were poor for the majority of the eyes in our series for a variety of reasons. First, many of these eyes had preexisting ocular abnormalities apart from the characteristic structural defects of Peters anomaly.…”

Section: Discussionmentioning

confidence: 99%

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Long-term visual outcome of penetrating keratoplasty in infants and children with Peters anomaly

Yang

Lambert

Drews‐Botsch

et al. 2009

Journal of American Association for Pediatric Ophthalmology and

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Section: Discussionmentioning

confidence: 99%

“…When the opacity obstructs the passage of light through the pupil, penetrating keratoplasty may be indicated. [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28] Postoperative optical correction and occlusion therapy are necessary to prevent abnormal visual experience and deprivation amblyopia.…”

mentioning

confidence: 99%

Long-term visual outcome of penetrating keratoplasty in infants and children with Peters anomaly

Yang

Lambert

Drews‐Botsch

et al. 2009

Journal of American Association for Pediatric Ophthalmology and

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“…Diverse ocular conditions have been associated with Peters anomaly, most commonly glaucoma, microphthalmia and coloboma [15]. Although glaucoma is common in patients with Peters anomaly, it was absent in our patients.…”

Section: Discussionmentioning

confidence: 48%

Peters Anomaly in Twins: A Case Report of a Rare Incident with Novel Comorbidities

Almarzouki

Tayyib

Khayat

et al. 2016

Case Rep Ophthalmol

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Introduction: Peters anomaly is a rare developmental malformation involving the anterior segment of the eye, which culminates in amblyopia or congenital blindness. Multiple ocular and/or systemic malformations have been observed with this anomaly, and novel comorbidities continue to be reported. Case Presentation: The probands were monozygotic twin boys (twin I and twin II) born to consanguineous parents at 36 weeks of gestation. Coarse facial features and deep-seated eyes were noted at birth. At 6 months, ophthalmic examination revealed that both twins were unable to blink in response to light, or to fixate and follow a moving object. Both twins had prominent horizontal nystagmus. Slit-lamp examination demonstrated varying degrees of central leukoma (corneal opacity) associated with iridocorneal adhesion, which is characteristic of type I Peters anomaly. No cataractous changes were observed. Normal intraocular pressure and disorganized retina were observed. Pupillary abnormalities included bilaterally underdeveloped pupils and bilateral absence of pupils was noted. Ocular MRI showed bilateral microphthalmia and optic nerve hypoplasia, with a small optic chiasm in both twins. At this age, the diagnosis of Peters anomaly was made. At 16 months of age, both twins developed deep venous thrombosis and purpuric skin lesions. Investigations revealed a hereditary thrombophilia secondary to a homozygous mutation causing protein C deficiency, which is a rare thrombotic condition. Ocular ultrasonography revealed bilateral vitreous hemorrhaging linked to altered coagulation. One twin developed bilateral inguinal hernia and cryptorchidism. Conclusion: The novel concordance of Peters anomaly in these monozygotic twins sharing a mutation in PROC gene provides further evidence that this anomaly has a genetic basis. Hypoplasia of the optic nerves and optic chiasm, along with severe protein C deficiency and bilateral absence of the pupils, are associated comorbidities that have not previously been reported with this anomaly.

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“…Other possible differential diagnoses include concurrent presence of congenital cataract, iris-cornea persistent pupillary membranes and resultant corneal leukoma. Amblyopia is often reported in people with Peters anomaly, 14 and vision deficits were suspected in the patient reported here. Vision deficits in this case could also be attributed to central corneal opacity and cataract presence.…”

Section: Brief Communicationmentioning

confidence: 53%

PETERS ANOMALY IN A RED KANGAROO (MACROPUS RUFUS)

Suedmeyer¹,

Pearce²,

Persky³

et al. 2014

Journal of Zoo and Wildlife Medicine

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A 10-mo-old female red kangaroo (Macropus rufus) presented with a unilateral congenital corneal opacity OD. Complete ophthalmic examination revealed a shallow anterior chamber and a focal area of corneal edema with multiple persistent pupillary membranes extending from the iris colarette to the corneal endothelium adjacent to the edematous area of cornea. High-resolution B-scan ultrasound of the anterior segment showed an area consistent with thinning of Descemet's membrane in the area of corneal edema. Ophthalmic examination and ultrasound findings are consistent with a diagnosis of Peters anomaly, a form of anterior segment dysgenesis. An electroretinogram performed on the affected animal did not reveal any specific abnormalities. Karyotype analyses revealed a normal diploid number (2n = 20, -XX), with an abnormal pericentric inversion in the second largest chromosomal pair. The kangaroo exhibits mild compensated vision deficits in the affected eye. The maternal and paternal adult pairing has been discontinued in an effort to prevent future offspring anomalies.

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Strabismus and Amblyopia in Bilateral Peters Anomaly

Cited by 26 publications

References 22 publications

Long-term visual outcome of penetrating keratoplasty in infants and children with Peters anomaly

Long-term visual outcome of penetrating keratoplasty in infants and children with Peters anomaly

Peters Anomaly in Twins: A Case Report of a Rare Incident with Novel Comorbidities

PETERS ANOMALY IN A RED KANGAROO (MACROPUS RUFUS)

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