Octyl methoxycinnamate: Two generation reproduction toxicity in Wistar rats by dietary administration

Inter‐laboratory control data for reproductive endpoints required in the OPPTS 870.3800/OECD 416 reproduction and fertility test

“…Mean spermatid counts/g testicular tissue (mean 5 142.2À159.5 Â 10 6 for Sprague-Dawley-derived rats; 106.2À109.2 Â 10 6 for Wistar-derived rats) were similar to previously reported spermatid concentrations in both strains (e.g., Tyl et al, 2004;Willoughby et al, 2000;Schneider et al, 2005;Suter et al, 1998). Despite this variability, spermatid counts generally are considered to be a more sensitive indicator of male reproductive toxicity than fertility because of excess sperm production in rats (Meistrich, 1989).…”

Sunscreens: are they beneficial for health? An overview of endocrine disrupting properties of UV‐filters

“…Those effects were seen at a dose of 0.24 mg/kg bw/day for 3‐BC and of 7 mg/kg bw/day for 4‐MBC. In contrast, the reproductive toxicity two generation study with OMC reported only delayed male and female puberty at the highest dose of 1000 mg/kg bw/day, which was not attributed to the compound, but rather to a natural variation within the ‘historical control range’, in spite of the statistically significant difference compared with control animals in the study (Schneider et al. , 2005).…”

“…In addition, at the same dose level an increased number of abnormal spermatozoa was observed in mice. Perinatal and early postnatal exposure to OMC in rats also resulted in decreased sperm count (Schneider et al. , 2005; Axelstad et al.…”

Skin absorption and human exposure estimation of three widely discussed UV filters in sunscreens – In vitro study mimicking real-life consumer habits

“…As the BP3 and EHMC structure are similar to estrogens, a number of experimental studies in a variety of screening systems (Schneider et al, 2005;Calafat et al, 2008;Schlumpf et al, 2008a,b;Zhang et al, 2011Zhang et al, , 2013Bluthgen et al, 2012;Oz aez et al, 2013;Kerdivel et al, 2013;Liao and Kannan, 2014;Watanabe et al, 2015) as well as review articles (SCCP, 2008;Axelstad et al, 2011Axelstad et al, , 2013WHO, 2012;Krause et al, 2012;Urek et al, 2013;Kim and Choi, 2014;Manov a et al, 2013) dealing with their influence on the endocrine system (oestrogen activity, progesterone activity, effect on reproduction, and other) were published in the past years. It should be emphasized, that conclusions on the potentially hormone-like activities of these filters were somewhat conflicting.…”