Octenidine Dihydrochloride, a Modern Antiseptic for Skin, Mucous Membranes and Wounds

Hübner, N.-O.; Siebert, Jörg; Krämer, Axel

doi:10.1159/000314699

Cited by 200 publications

(167 citation statements)

References 130 publications

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“…The results obtained in this study encourage considering OCT, which is well tolerated and without resistances reported so far [18], as an alternative antiseptic for controlling the spread of MR bacteria, either being Gram-positive or Gramnegative. Further studies are required to better evaluate the impact of OCT in clinical practice for preventing infections caused by MRGN, such as that recently performed by Gastmeier et al [19], who showed no significant impact on the prevention of MRGN acquisition in intensive care units.…”

Section: Discussionsupporting

confidence: 63%

Antimicrobial activity of octenidine against multidrug-resistant Gram-negative pathogens

Álvarez‐Marín

Aires-de-Sousa

Nordmann

et al. 2017

Eur J Clin Microbiol Infect Dis

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Multidrug-resistant (MR) Gram-negative (GN) pathogens pose a major and growing threat for healthcare systems, as therapy of infections is often limited due to the lack of available systemic antibiotics. Well-tolerated antiseptics, such as octenidine dihydrochloride (OCT), may be a very useful tool in infection control to reduce the dissemination of MRGN. This study aimed to investigate the bactericidal activity of OCT against international epidemic clones of MRGN. A set of five different species (Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, Acinetobacter baumannii, and Pseudomonas aeruginosa) was studied to prove OCT efficacy without organic load, under Bclean conditions^(0.3 g/L albumin) and under Bdirty conditions( 3 g/L albumin + 3 mL/L defibrinated sheep blood), according to an official test norm (EN13727). We used five clonally unrelated isolates per species, including a susceptible wildtype strain, and four MRGN isolates, corresponding to either the 3MRGN or 4MRGN definition of multidrug resistance. A contact time of 1 min was fully effective for all isolates by using different OCT concentrations (0.01% and 0.05%), with a bacterial reduction factor of >5 log 10 systematically observed. Growth kinetics were determined with two different wild-type strains (A. baumannii and K. pneumoniae), proving a time-dependent efficacy of OCT. These results highlight that OCT may be extremely useful to eradicate emerging highly resistant Gram-negative pathogens associated with nosocomial infections.

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Section: Discussionsupporting

confidence: 63%

Antimicrobial activity of octenidine against multidrug-resistant Gram-negative pathogens

Álvarez‐Marín

Aires-de-Sousa

Nordmann

et al. 2017

Eur J Clin Microbiol Infect Dis

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“…33,34 OCT is commonly used at a concentration of 0.1%-0.2% and PHMB is used at 0.2% as an antiseptic. 25,35,36 It was demonstrated that all antiseptic solutions had both bacteriostatic and bactericidal effects against the test microorganisms, as CHX was used at 150 mg/L and OCT and PHMB were used at 120 mg/L in the present study. All of the bacterial groups that were chosen as the test microorganisms in this study were the most common cariogenic bacteria isolated from caries lesions.…”

Section: Discussionmentioning

confidence: 66%

Antimicrobial activity of different disinfectants against cariogenic microorganisms

et al. 2016

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The aim of this study was to assess the in vitro antimicrobial effects of chlorhexidine digluconate (CHX), polyhexamethylene biguanide (PHBM), and octenidine dihydrochloride (OCT) on cariogenic microorganisms by using their minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). CHX, PHBM, and OCT were diluted in distilled water to the final test concentrations. Using the in-tube dilution method, Streptococcus mutans, Lactobacillus acidophilus, Lactobacillus rhamnosus, and Actinomyces viscosus were cultivated on blood agar and Mueller-Hinton broth (MHB) at 37°C for 48 h. They were read using a spectrophotometer to detect MIC. To determine MBC, samples in the range of the turbidity threshold after 24 h were transferred onto blood agar and evaluated for growth after 24 h. Different MICs and MBCs were observed in all disinfectants against each microorganism. The lowest MIC and MBC against S. mutans (60 mg/L) were obtained from PHBM.The lowest values against L. rhamnosus (15 mg/L, 30 mg/L), A. viscosus (30 mg/L), and L. acidophilus (15 mg/L, 30 mg/L) were determined by OCT. PHBM and OCT have the potential to be replaced with CHX because they were effective against cariogenic microorganisms.

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“…Octenidine dihydrochloride is a cationic lipophilic biocide of high molecular weight ( Fig. 1; Table 1) and is an efficient antiseptic for skin, mucous membranes, and wounds (15). The efficacy of the bispyridine derivative octenidine was reduced 2-fold by deletion of the main M. smegmatis porin MspA, but not by further deletions of mspC and mspD (Table 1; Fig.…”

Section: Resultsmentioning

confidence: 99%

Importance of Porins for Biocide Efficacy against Mycobacterium smegmatis

Frenzel

Schmidt

Niederweis

et al. 2011

Appl Environ Microbiol

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Octenidine Dihydrochloride, a Modern Antiseptic for Skin, Mucous Membranes and Wounds

Cited by 200 publications

References 130 publications

Antimicrobial activity of octenidine against multidrug-resistant Gram-negative pathogens

Antimicrobial activity of octenidine against multidrug-resistant Gram-negative pathogens

Antimicrobial activity of different disinfectants against cariogenic microorganisms

Importance of Porins for Biocide Efficacy against Mycobacterium smegmatis

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