OCTA vessel density changes in the macular zone in glaucomatous eyes

Lommatzsch, Claudia; Rothaus, Kai; Koch, Jörg; Heinz, Carsten; Grisanti, Salvatore

doi:10.1007/s00417-018-3965-1

Cited by 69 publications

(58 citation statements)

References 40 publications

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“…13 It has been reported previously that papillary and macular VD is lower in glaucomatous eyes than in age-matched normal eyes. 11,14 We were able to learn from our preliminary work that in glaucomatous eyes vessel density is significantly reduced in comparison to healthy eyes 15,29 and that on average in healthy eyes there is a papillary vessel density of more than 50%. 29 Most of the research using OCTA has compared the VD of healthy eyes and eyes with POAG, with few publications considering different glaucoma entities in detail.…”

Section: Discussionmentioning

confidence: 94%

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<p>Vessel Density in Glaucoma of Different Entities as Measured with Optical Coherence Tomography Angiography</p>

Lommatzsch

Rothaus

et al. 2019

OPTH

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Purpose: To compare papillary and macular vessel density (VD), as measured by optical coherence tomography angiography (OCTA), in eyes with primary open-angle glaucoma (POAG), normal-tension glaucoma (NTG) and exfoliation glaucoma (XFG). Methods: The papillary and macular VD of 40 eyes with POAG, 19 with NTG and 21 with XFG were examined using OCTA (AngioVue™). The VD was measured at two different layers of segmentation (optic nerve head: radial peripapillary capillary [RPC] and nerve head [NH]; macula: superficial [SL] and deep [DL] retinal vascular plexus) with a 4.5×4.5mm papillary and 6×6-mm macular scan. VD was calculated by an automated density measuring tool in the AngioVue™ software.Results: There were no significant differences in the total value of the papillary, peripapillary and macular VD. A significantly higher VD could be measured for NTG compared to POAG, as well as for XFG in the inferior nasal peripapillary sector at RPC-segmentation and at the NH-level between NDG and XFG. Conclusion: OCTA can detect a difference in VD in the nasal inferior peripapillary sector in NTG compared with POAG and XFG. These findings may help to improve the understanding of further pathophysiological mechanisms.

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Section: Discussionmentioning

confidence: 94%

“…13 In glaucoma disease, VD has been shown to be reduced in the area of the ONH and the macula. 11,[14][15][16] To ascertain whether the vascular phenomenon is more profound in certain entities of glaucoma, we investigated the VD of the ONH and the macula by OCTA in POAG, NTG, and XFG.…”

Section: Introductionmentioning

confidence: 99%

<p>Vessel Density in Glaucoma of Different Entities as Measured with Optical Coherence Tomography Angiography</p>

Lommatzsch

Rothaus

et al. 2019

OPTH

Self Cite

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“…For example, glaucoma is also a neurodegenerative disease with progressive loss of neuronal tissue and results in reduced vessel density. 20 Macular pathology such as an epiretinal membrane or AMD, which are not uncommon in an older adult populations also impact segmentation of the OCTA and, thus, affect vessel and perfusion density measurements. Another limitation is that current studies have excluded patients with known vascular diseases, so it is not yet known whether these results translate to patients with concurrent retinal microvasculature changes from other etiologies such as diabetes and hypertension, which are prevalent in the aging population at risk of neurodegenerative diseases.…”

Section: Limitations Of Current Octa Analysis In Neurodegenerative DImentioning

confidence: 99%

Is OCT Angiography Useful in Neurodegenerative Diseases?

Grewal¹,

Fine²,

Fekrat³

2019

Ophthalmic Surg Lasers Imaging Retina

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“…Physiological evidence also supports that the macula is more sensitive to hypoxia and ischaemia because it consumes more oxygen than other tissues in the body 17 . Subsequently, macular VD and foveal avascular zone (FAZ) metrics were regarded as potential biomarkers in the clinical evaluation of early glaucoma in recent studies 18 – 20 . However, few researches have examined macular vasculature in PACG.…”

Section: Introductionmentioning

confidence: 99%

Macular vessel density and foveal avascular zone parameters in patients after acute primary angle closure determined by OCT angiography

Liu

Jiang

et al. 2020

Sci Rep

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This study analyzed the optical coherence tomography angiography (OCTA) macular parameters in primary angle-closure glaucoma (PACG) patients after acute primary angle closure (APAC) episodes. Thirty-three patients with 33 APAC eyes and 33 primary angle closure suspect (PACS) eyes and 33 age-matched normal subjects (controls) were enrolled. Macular vessel density (VD) in central, inner, outer and full regions and foveal avascular zone (FAZ) parameters (area, perimeter and circularity index) were compared between APAC, PACS, and control eyes. For resolved APAC eyes, the VD in each macular region was significantly lower than that in control eyes, with less central and inner macular VD than PACS eyes. The central macular VD was significantly lower in PACS eyes than in controls. There was no difference in FAZ area and perimeter between APAC, PACS, and control eyes. FAZ circularity was highest in control eyes, followed by PACS eyes, and lowest in APAC eyes. The AUC, sensitivity and specificity of FAZ circularity were 0.944, 93.9% and 84.8%, respectively, in APAC eyes and 0.881, 84.8% and 81.8%, respectively, in PACS eyes. Therefore, FAZ circularity had the best discrimination capability for detecting both APAC and PACS eyes. Macular assessment with OCTA could provide an accurate early-stage diagnostic tool for PACG.

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OCTA vessel density changes in the macular zone in glaucomatous eyes

Abstract: OCTA detects glaucomatous damage by measuring the macular vessel density in the superficial and deep retinal vascular plexus. It can be an additional diagnostic tool to detect glaucoma independently of the optic nerve.

Cited by 69 publications

References 40 publications

<p>Vessel Density in Glaucoma of Different Entities as Measured with Optical Coherence Tomography Angiography</p>

<p>Vessel Density in Glaucoma of Different Entities as Measured with Optical Coherence Tomography Angiography</p>

Is OCT Angiography Useful in Neurodegenerative Diseases?

Macular vessel density and foveal avascular zone parameters in patients after acute primary angle closure determined by OCT angiography

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