OCT Angiography: Imaging of Choroidal and Retinal Tumors

Toledo, Juan José; Asencio, Mónica; García, Jesús Ramón; Morales, Liliana A.; Tomkinson, Claire; Cajigal, Clara

doi:10.1016/j.oret.2017.10.006

Cited by 39 publications

(42 citation statements)

References 15 publications

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“…Further efforts have been made to find differentiating features in OCTA of choroidal melanoma in comparison with choroidal nevus. Toledo et al reported qualitative assessment of melanocytic lesions, including choroidal nevus with different risk factors for malignancy and frank CHMM, and found that hyperreflective encompassing rings and the presence of intrinsic hyporeflective plexus are indicative of malignant melanocytic lesions [ 24 ]. However, not all choroidal melanomas exhibited these features, or were they unique to malignant lesions (Fig.…”

Section: Melanocytic Lesionsmentioning

confidence: 99%

“…It is hypothesized that lack of blood flow within the metastatic tumour might be due to the shadowing artefact of the overlying retinal oedema and pigment epithelium, or the high velocity of blood flow within the tumour’s vasculature (i.e., fringe effect) [ 62 ]. However, there are also reports of the observation of thick anastomotic vessels alongside thinner vasculature and hyporeflective avascular regions in OCTA images acquired by “OCT microangiography-complex” algorithm [ 24 ] (Fig. 8 ).…”

Section: Choroidal Metastasesmentioning

confidence: 99%

“…Hypervascularity of the tumour is also evident by a dense organization of capillary plexus in en face images [ 66 ]. Theoretically, visualization of intrinsic vasculature in peripheral tumours can be beneficial in monitoring of treatment response [ 24 ].…”

Section: Miscellaneous Posterior Segment Tumoursmentioning

confidence: 99%

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Optical coherence tomography angiography (OCTA) applications in ocular oncology

Naseripour

Falavarjani

Mirshahi

et al. 2020

Eye

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Optical coherence tomography angiography (OCTA) is a revolutionary method in the visualization of the vascular system in different retinal and choroidal layers. During the last 4 years since the commercial availability of different OCTA devices, attempts have been made to utilize this technology in various aspects of ocular oncology from the differentiation of benign and malignant lesions to assisting in evaluation of post-treatment complications, such as radiation retinopathy. However, current OCTA technology is restricted by various artefacts and inherent limitations, some of which are more pronounced in the presence of elevated tumoural lesions. Imminent advancements in OCTA systems and image acquisition processes promise a great potential for application of OCTA in ocular oncology.

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Section: Melanocytic Lesionsmentioning

confidence: 99%

Section: Choroidal Metastasesmentioning

confidence: 99%

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Optical coherence tomography angiography (OCTA) applications in ocular oncology

Naseripour

Falavarjani

Mirshahi

et al. 2020

Eye

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“…Вышеуказанные факты диктуют необходимость более глубокого исследования невуса и меланомы хориоидеи для дифференциальной диагностики и выявления уже на ранних стадиях признаков трансформации невуса в меланому хориоидеи. К методам диагностики начальной меланомы и невуса хориоидеи относят офтальмоскопию, УЗИ, ФАГ, СОКТ, ОКТ-А [1][2][3][9][10][11][12][13][14][15][16][17][18][19].…”

Section: Discussionunclassified

“…В последние годы появление новой модификации оптической когерентной томографии с ангиографическим режимом позволило неинвазивно определять сосудистую сеть [14][15][16][17][18][19]. Метод основан на оценке колебаний амплитуды отраженного сигнала между последовательными срезами (ангиография с разделением спектра и амплитудой декорреляции (split-spectrum amplitude-decorrelation angiography -SSADA) [14][15][16][17][18][19]. Одной из важных особенностей ОКТА является возможность послойной визуализации сосудистой сети сетчатки и хориоидеи с количественной оценкой параметров кровотока [14][15][16].…”

Section: Introductionunclassified

OCT-Angiography in Early Choroidal Melanoma and Choroidal Nevi

et al. 2020

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Purpose: To study the features of small choroidal melanoma and choroidal nevi angioarchitectonics using the optical coherence tomography angiography (OCTA).Patients and methods. We examined 128 patients with small choroidal neoplasms: 41 — with small choroidal melanoma (group 1), 42 — with suspicious nevi (group 2) and 45 — with benign nevi (group 3). All patients underwent general ophthalmic examinations and special instrumental diagnostic methods (ultrasound examination (US), fluorescence angiography (FA), spectral optical coherence tomography (SOCT), OCTA).Results. OCTA in all patients with small choroidal melanoma showed neovascular network under retinal pigment epithelium. We found a looped, cranked-twisted, heterogeneous vascular network with uneven clearance and with numerous bends and weaves, located under the vessels of retina. The limiting avascular zone corresponding to the tumor slope was determined in 19 (46.3 %) of 41 cases. There was a rim of dilated hyperreflective choriocapillaries on the periphery of the tumor. We identified hyperreflective homogeneous enlarged choriocapillaries in the focus area with a brighter glow than the surrounding choriocapillaries in 39 (92.9 %) of 42 patients with suspicious choroidal nevus. We detected an avascular zone with surrounding extended hyperreflective choriocapillaries in the center of the nevus in 3 (7.1 %) of 42 cases. We diagnosed homogeneous isoreflective choriocapillaries similar in brightness to the surrounding vessels in all 45 patients with benign nevi.Conclusions. Thus, the complex of clinical and instrumental methods, including OCTA, makes it possible to establish the diagnosis of malignant tumor of the choroid in early stages. At the same time, OCTA: 1) allows to visualize of the tumor vessels in the choroidal layer in 100 % of cases of in small choroidal melanoma; 2) makes it possible to distinguish the newly formed tumor vessels from the choriocapillaries in case of small choroidal melanoma; 3) provides an opportunity to establish the correct diagnosis and provide timely assistance to patients with benign and malignant choroidal tumors.

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Choroidal Hemangiomas

Aronow

Gragoudas

2022

Albert and Jakobiec's Principles and Practice of Ophthalmology

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OCT Angiography: Imaging of Choroidal and Retinal Tumors

Cited by 39 publications

References 15 publications

Optical coherence tomography angiography (OCTA) applications in ocular oncology

Optical coherence tomography angiography (OCTA) applications in ocular oncology

OCT-Angiography in Early Choroidal Melanoma and Choroidal Nevi

Choroidal Hemangiomas

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