Ochratoxin A: its impact on poultry gut health and microbiota, an overview

Zhai, Shuangshuang; Zhu, Yongwen; Feng, Peishi; Li, Macheng; Wang, Wence; Yang, Lin; Yang, Ye

doi:10.1016/j.psj.2021.101037

Cited by 44 publications

(28 citation statements)

References 98 publications

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“…In contrast, the presence of OTA at the concentration of 1 mg/kg in the ingested feed negatively affected laying hen productive performance. It is well known that OTA in ingested feed negatively affects the microvilli of the intestine, including increasing gut permeability, immunity, and bacterial translocation, thereby reducing nutrient absorption [ 21 ]. Overall, during the entire experiment, the addition of MZ as a feed additive effectively ameliorated the negative effect of OTA and had significant beneficial effects on body weight, feed consumption, and the number of eggs of laying hens.…”

Section: Resultsmentioning

confidence: 99%

Efficacy of a Modified Clinoptilolite Based Adsorbent in Reducing Detrimental Effects of Ochratoxin A in Laying Hens

Vasiljević

Marinković

Milićević

et al. 2021

Toxins

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Background: The objective of this study was to evaluate the efficacy of modified clinoptilolite (Minazel Plus®, MZ) as a mycotoxin adsorbent for preventing the negative the effects of ochratoxin A (OTA) on performance, pathohistological changes, and OTA residue in the eggs of laying hens. Methods: Forty eight (n = 48) laying hens (27 weeks old) were equally divided into six groups and depending on the type of addition were allocated to the following experimental treatments for 7 weeks: E-I group-1 mg/kg OTA; E-II group 0.25 mg/kg OTA; E-III group 1 mg/kg OTA + 0.2% of MZ; E-IV group 0.25 mg/kg OTA + 0.2% of MZ; MZ group supplemented with 0.2% of the adsorbent; and control (K, without feed additive). Results: Overall, the addition of 0.2% MZ to laying hen feed mitigated the harmful effects of OTA on target organs and reduced the presence of OTA residue in eggs. The groups that received 0.2% of MZ achieved better production results in terms of body weight, number of eggs, and feed consumption, compared to the other treatments. Conclusions: The current findings confirm the efficacy of MZ in preventing performance losses in laying hens exposed to OTA, as well as for improving the welfare and health of food producing animals.

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Section: Resultsmentioning

confidence: 99%

Efficacy of a Modified Clinoptilolite Based Adsorbent in Reducing Detrimental Effects of Ochratoxin A in Laying Hens

Vasiljević

Marinković

Milićević

et al. 2021

Toxins

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“…The mycotoxins have profound interactions with the gut microbiota, particularly in animals, since some mycotoxins exhibit antimicrobial properties, while others are biotransformed by microbiota [ 52 ]. It is well known that the absorption rate of OTA is low in poultry, and the unabsorbed OTA could reach the hindgut to interact with the intestinal microbiota [ 9 ]. Ouethrani et al [ 53 ] noted that OTA caused a specific, but lasting, loss of the beneficial bacteria in the human colon, including Lactobacillus spp.…”

Section: Discussionmentioning

confidence: 99%

“…OTA is classified by the International Agency for Research on Cancer as a possible human carcinogen (Group 2B) and is associated with immunotoxic, neurotoxic, hepatotoxic and embryotoxic effects in both humans and animals. OTA is a very stable substance in high thermal conditions and thus is very difficult to eliminate by physical methods, once occurred in the feed [ 9 ]. OTA is primarily produced under storage conditions and frequently co-occurs with other mycotoxins [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

“…On the other hand, OTA is principally nephrotoxic and is associated with kidney enlargement and hyperplasia of the tubular epithelium [ 14 ]. Both mycotoxins have been further associated with significant alterations in the biochemical profile of birds, decreased nutrient digestibility, suppression of digestive enzymes and decreased serum proteins—in sum, affecting productivity and profitability [ 3 , 8 , 9 , 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

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Investigation of a Novel Multicomponent Mycotoxin Detoxifying Agent in Amelioration of Mycotoxicosis Induced by Aflatoxin-B1 and Ochratoxin A in Broiler Chicks

Tsiouris

Tassis

Raj³

et al. 2021

Toxins

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The present study was designed to determine the efficacy of a novel multicomponent mycotoxin detoxifying agent (MMDA) containing modified zeolite (Clinoptilolite), Bacillus subtilis, B. licheniformis, Saccharomyces cerevisiae cell walls and silymarin against the deleterious effects of Aflatoxin B1 (AFB1) and Ochratoxin A (OTA) in broiler chicks. A total of 160 one-day-old Ross 308® broiler chicks were randomly allocated in four treatment groups, with four replicates, according to the following experimental design for 42 days. Group A received a basal diet; Group B received a basal diet contaminated with AFB1 and OTA at 0.1 mg/kg and 1 mg/kg, respectively; Group C received a basal diet contaminated with AFB1 and OTA and MMDA at 1 g/kg feed, and Group D received a basal diet contaminated with AFB1 and OTA and MMDA at 3 g/kg feed. Results showed that ingested mycotoxins led to significant (p ≤ 0.05) reduction in body weight and feed conversion from 25 days of age, induced histopathological changes, increased the pH of the intestinal content, and altered the biochemical profile of birds with significantly (p ≤ 0.05) increased aspartate aminotransferase (AST) values (p ≤ 0.05). On the other hand, the supplementation of MMDA significantly (p ≤ 0.05) improved the feed conversion ratio (FCR) during the second part of the study, diminished biochemical alterations, reduced pH in jejunal and ileal content, and E. coli counts in the caeca of birds (p ≤ 0.05). It may be concluded that the dietary supplementation of the MMDA partially ameliorated the adverse effects of AFB1 and OTA in broilers and could be an efficient tool in a mycotoxin control program.

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“…1 MMDA, mycotoxin binder; 2 LDG, lactate dehydrogenase; 3 GGT, gamma-glutamyl transferase; 4 AST, aspartate aminotransferase; 5 ALT, alanine aminotransferase; 6 ALB, albumin;7 Tot prot, total proteins; 8 Trig, triglycerides;9 Chol, cholesterol; 10 Glu, glucose;11 OTA, ochratoxin A; 12 SEM, standard error of mean (n = 12); a,b : means values with different superscripts with the same column differ (p ≤ 0.05).…”

mentioning

confidence: 99%

Effect of a Mycotoxin Binder (MMDA) on the Growth Performance, Blood and Carcass Characteristics of Broilers Fed Ochratoxin A and T-2 Mycotoxin Contaminated Diets

Riahi

Ramos

Raj³

et al. 2021

Animals

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The present study was conducted to evaluate the efficacy of the feed additive, a novel multicomponent mycotoxin detoxifying agent (MMDA) containing modified zeolite (clinoptilolite), Bacillus subtilis, B. licheniformis, Saccharomyces cerevisiae cell walls, and silymarin, as detoxifiers of 0.5 mg/kg (0.5 ppm) ochratoxin A (OTA) and 1 mg/kg (1 ppm) T-2 toxin on broiler chickens. A total of 240 1-old broiler chickens (Ross 308) were randomly distributed into five different dietary treatments: (1) control (non-contaminated diet); (2) non contaminated diet + 3 g/kg of MMDA; (3) non-contaminated diet + 0.5 mg/kg OTA + 1 mg/kg T-2 toxin; (4) non-contaminated diet + 0.5 mg/kg OTA + 1 mg/kg T-2 toxin + 1 g/kg MMDA; and (5) non-contaminated diet + 0.5 mg/kg OTA + 1 g/kg T-2 toxin + 3 g/kg MMDA. The results showed that, in the starter period, from 1 to 10 days, the presence of OTA and T-2 mycotoxins reduced the consumption of feed and the growth of the broilers, and no effects of the detoxifying product were observed in the productivity of the chickens, at any of the doses tested, compared to the contaminated control (treatment 3). However, in the growing period, the same negative effect of mycotoxins was registered, but a recovery was observed in the consumption of feed and in the weight of the broilers that consumed 3 g/kg of the MMDA mycotoxin binder, reaching similar values to those of chickens fed uncontaminated control diets. The presence of mycotoxins in feed led to a reduction in the concentration of total proteins and albumin in blood compared to controls, and the presence of the detoxifying product partially reversed this effect. The breast yield of the chickens fed with mycotoxins was lower than that of the animals fed with the control feed and was not affected by the presence of the product tested, at 1 or 3 g/kg. The weight of the different organs (liver, gizzard, kidneys, or spleen), the intestinal pH, the histology of the small intestine, and oral lesions were not affected by the experimental treatments. In summary, the productive parameters and some blood and carcass characteristics of broiler chickens were impaired by the dietary presence of OTA and T-2 toxin. The tested product included at 1 or 3 g/kg feed in contaminated diets improved performance and seems to be effective in partly counteracting the deleterious effects of the tested mycotoxins.

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Ochratoxin A: its impact on poultry gut health and microbiota, an overview

Cited by 44 publications

References 98 publications

Efficacy of a Modified Clinoptilolite Based Adsorbent in Reducing Detrimental Effects of Ochratoxin A in Laying Hens

Efficacy of a Modified Clinoptilolite Based Adsorbent in Reducing Detrimental Effects of Ochratoxin A in Laying Hens

Investigation of a Novel Multicomponent Mycotoxin Detoxifying Agent in Amelioration of Mycotoxicosis Induced by Aflatoxin-B1 and Ochratoxin A in Broiler Chicks

Effect of a Mycotoxin Binder (MMDA) on the Growth Performance, Blood and Carcass Characteristics of Broilers Fed Ochratoxin A and T-2 Mycotoxin Contaminated Diets

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