Efficacy of a Modified Clinoptilolite Based Adsorbent in Reducing Detrimental Effects of Ochratoxin A in Laying Hens

Abstract

Background: The objective of this study was to evaluate the efficacy of modified clinoptilolite (Minazel Plus®, MZ) as a mycotoxin adsorbent for preventing the negative the effects of ochratoxin A (OTA) on performance, pathohistological changes, and OTA residue in the eggs of laying hens. Methods: Forty eight (n = 48) laying hens (27 weeks old) were equally divided into six groups and depending on the type of addition were allocated to the following experimental treatments for 7 weeks: E-I group-1 mg/kg OTA; E-II group 0.25 mg/kg OTA; E-III group 1 mg/kg OTA + 0.2% of MZ; E-IV group 0.25 mg/kg OTA + 0.2% of MZ; MZ group supplemented with 0.2% of the adsorbent; and control (K, without feed additive). Results: Overall, the addition of 0.2% MZ to laying hen feed mitigated the harmful effects of OTA on target organs and reduced the presence of OTA residue in eggs. The groups that received 0.2% of MZ achieved better production results in terms of body weight, number of eggs, and feed consumption, compared to the other treatments. Conclusions: The current findings confirm the efficacy of MZ in preventing performance losses in laying hens exposed to OTA, as well as for improving the welfare and health of food producing animals.

Effect of Modified Clinoptilolite to Counteract the Deleterious Effects of Ochratoxin A on Egg Production and Quality

“…FCR was improved in the group of laying hens fed the diet supplemented with MZ by 14%, when compared with the group that consumed feeds contaminated with 1 mg of OTA/kg of feed. The assessment of the differences in FCR between groups observed in our study, support the results of a previous study where the inclusion of MZ in laying hen feed could increase feed efficiency (Vasiljević et al, 2021). Due to feed costs constitute the greatest share of total costs in intensive poultry production, FCR is a…”

Evaluation of Effectiveness of a Novel Multicomponent Mycotoxins Detoxification Agent in the Presence of AFB1 and T-2 Toxin on Broiler Chicks

“…are utilized by the feed industry due to their positive probiotic effects in the gastrointestinal tract [ 28 ]. The efficacy of several adsorbents such as modified clinoptilolite in poultry feed decontamination have been extensively studied, but most of the studies are focused on only one or two mycotoxins such as aflatoxin and/or ochratoxin [ 29 , 30 ] or T-2 toxin [ 31 ]. Hence, the current study aims to evaluate the efficacy of the MR agent to reduce the adverse effects of moderate concentrations of AFB1 and T-2 toxin, individually or combined, and to test its efficacy on the performance and health of broiler chickens fed an artificially contaminated diet.…”

Degradation of ochratoxins A and B by lipases: A kinetic study unraveled by molecular modeling

“…OTA and OTB are considered intermediate polar mycotoxins, or even nonpolar, as some authors claim [ [70] , [71] , [72] ], and considering the pocket hydrophobicity, given by the nonpolar amino acids ( Fig. 4 B), it would be reasonable to assume that both substrates would find it easy to enter the pocket and interact.…”