Occurrence of Haemophylus influenzae B meningitis after the implementation of a mass vaccination program

Kmetzsch, Claudete Iris; Schermann, Maria Tereza; Santana, João Carlos Batista; Estima, Carmem L.; Faraco, Fernando J.; Silva, Cláudia M.; Conceição, Roque

doi:10.2223/jped.1114

Cited by 6 publications

(10 citation statements)

References 7 publications

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“…Five studies reported data on Hib vaccine, [26][27][28][29][30] eight on pneumococcal vaccine, [31][32][33][34][35][36][37][38] and the remaining ten studies reported data on rotavirus vaccine. [39][40][41][42][43][44][45][46][47][48] The studies came from nine countries, Argentina, Brazil, Chile, Cuba, El Salvador, Mexico, Nicaragua, Panama, and Uruguay.…”

Section: Search Resultsmentioning

confidence: 99%

“…Four studies described the incidence of hospitalization for Hib-confirmed meningitis after introduction of Hib vaccination, three in Brazil 27,28,30 and one in Cuba 26 (Table 1). All four studies showed a decrease in incidence after vaccination in children aged < 1 year, the age group targeted for vaccination (Supplementary Table 1).…”

Section: Hib Vaccinementioning

confidence: 99%

“…In children aged < 1 year in Brazil incidence decreased from 36.5 per 100,000 to 3.4 per 100,000 (p < 0.005), and in children aged 1-4 years the decrease was from 6.4 per 100,000 to 0.7 per 100,000 (p < 0.02). 27 All four studies included older children, whereas only one 27 included adults, with a very low incidence previous to vaccine introduction; this study has a post-vaccination period of 2 years (Table 1).…”

Section: Hib Vaccinementioning

confidence: 99%

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Vaccination herd effect experience in Latin America: a systematic literature review

DeAntonio¹,

Amador²,

Bunge³

et al. 2018

Human Vaccines & Immunotherapeutics

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After introduction of Hib, PCV and rotavirus vaccination in LatAm, reductions in morbidity/mortality have been reported in children not targeted for vaccination. However, due to methodological limitations (e.g. short post-vaccination periods and age range studied), there is currently insufficient evidence to quantify the herd effect in adult populations. More research and higher quality surveillance is needed to characterize herd effect of these vaccines in LatAm.

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Section: Search Resultsmentioning

confidence: 99%

Section: Hib Vaccinementioning

confidence: 99%

Section: Hib Vaccinementioning

confidence: 99%

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Vaccination herd effect experience in Latin America: a systematic literature review

DeAntonio¹,

Amador²,

Bunge³

et al. 2018

Human Vaccines & Immunotherapeutics

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“…After the introduction of the Hib vaccine in the Brazilian official calendar in 1999 there was more than 90% reduction in number of meningitis cases by this agent. Reinforcing this fact, IAL laboratory data show that the national percentage of isolation of Hib strains decreased 88% after the introduction of Hib vaccine in Brazil 3,6 . Additionally, there was a reduction in the number of Hib isolates in the post-vaccination (2000-2008) compared to the pre-vaccination (1990-1999) period, i.e., 98% of the Hi strains serotyped by IAL during pre-vacci ne period were serotype b while only 59% were Hib in the postvaccine.…”

mentioning

confidence: 84%

Evolution of bacterial meningitis diagnosis in Sao Paulo State-Brazil and future challenges

Salgado

Gonçalves

Fukasawa

et al. 2013

Arq. Neuro-Psiquiatr.

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Bacterial meningitis (BM) is a severe disease and still represents a serious public health problem with high rates of morbidity and mortality . Additionally, there was a reduction in the number of Hib isolates in the post-vaccination (2000)(2001)(2002)(2003)(2004)(2005)(2006)(2007)(2008) compared to the pre-vaccination (1990-1999) period, i.e., 98% of the Hi strains serotyped by IAL during pre-vacci ne period were serotype b while only 59% were Hib in the postvaccine. Furthermore, there was an increase from 1% to 19% Keywords: Bacterial meningitis, molecular diagnosis, real time PCR. rESUMO A meningite bacteriana (MB) é uma doença grave e ainda representa um sério problema de saúde pública, com altas taxas de morbidade e mortalidade. Os casos mais comuns de MB em todo o mundo, principalmente no Brasil, tem sido causados por Neisseria meningitidis, Streptococcus pneumoniae e Haemophilus influenzae tipo b. Cultura bacteriana é a técnica padrão-ouro para a confirmação de MB, mas cerca de 50% dos casos suspeitos não são confirmados por cultura, devido a problemas relacionados ao transporte inadequado e semeadura ou antibioticoterapia prévia. Métodos imunológicos apresentam baixa sensibilidade e têm possibilidade de reações cruzadas. PCR em tempo real (qPCR) é uma técnica molecular e tem sido utilizada com êxito para o diagnóstico de MB no Instituto Adolfo Lutz, em São Paulo, Brasil, desde 2007. A incorporação da qPCR na rotina de vigilância em Saúde Pública em nosso estado resultou na diminuição de 50% dos casos de MB indeterminadas. Nossos esforços estão focados na implementação da qPCR na rotina diagnóstica de MB em todo o Brasil.Palavras-Chave: Meningite bacteriana, diagnóstico molecular, PCR em tempo real.

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“…Dados de vigilância nesses países detectaram declínio superior a 80% na meningite por Hib logo após a introdução da vacina 14,26,29,33 . Na América Latina, avaliações do impacto da vacinação nas meningites foram realizadas em Cuba, Colômbia, Uruguai, Chile e Brasil 31 , mostrando que as taxas de incidência de meningite por Hib no período pós-vacinal declinaram de 40 a 95%, comparadas ao período pré-vacinação, conforme mostrado na Tabela 1 22,[34][35][36][37][38][39][40][41][42] .…”

Section: Vacina Hib Incluída No Programaunclassified

<i>Haemophilus influenzae</i> type b vaccination: long-term protection

Nascimento‐Carvalho¹,

Andrade²

2006

J Pediatr (Rio J)

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Objective: To identify evidence of the impact of Haemophilus influenzae type b (Hib) conjugate vaccine on the epidemiology of invasive Hib disease. Sources of data:This review was based on a search of MEDLINE, LILACS, technical reports, national and international guidelines (publications from 1991 to 2005). The keywords Haemophilus influenzae type b, immunization, impact and effectiveness, alone or in combination, were used to retrieve the articles. Studies published before 1991 and cited in the references of the studies reviewed were analyzed for useful information.Summary of the findings: Introduction of the Hib conjugate vaccine produced great decline in the incidence of invasive Hib disease in childhood in countries where this vaccine was introduced into the routine immunization schedule. Nevertheless, the resurgence of invasive Hib disease in some regions has challenged several researchers to identify the reasons for this epidemiological pattern, as well as the measures to be implemented in order to avoid such a phenomenon. Conclusions:The use of Hib conjugate vaccine on a population scale has been greatly effective; nonetheless, changes in the vaccination scheme seem to be necessary to keep invasive Hib disease under control.J Pediatr (Rio J). 2006;82(3 Suppl):S109-14: Haemophilus influenzae type b, immunization, vaccine, meningitis, pneumonia. ResumoObjetivo: Identificar as evidências sobre o impacto da vacina conjugada para Haemophilus influenzae tipo b (Hib) na epidemiologia da doença invasiva por Hib.Fontes dos dados: Pesquisa nas bases de dados do MEDLINE, LILACS, publicações técnicas de organizações internacionais, diretrizes nacionais e internacionais, nos últimos 15 anos (1991)(1992)(1993)(1994)(1995)(1996)(1997)(1998)(1999)(2000)(2001)(2002)(2003)(2004)(2005), utilizando os seguintes unitermos: Haemophilus influenzae type b, immunization, impact, effectiveness. Foram incluídas as publicações que apresentaram informação para atender o objetivo deste artigo. Artigos publicados em período anterior ao da pesquisa e citados em referências dos artigos incluídos foram analisados quanto à apresentação de informação de interesse. Síntese dos dados:A introdução da vacina conjugada para Hib produziu grande declínio na incidência de casos de doença invasiva por Hib nos diversos países em que seu uso foi incorporado à rotina de vacinação das crianças. No entanto, o ressurgimento de casos com doença invasiva por Hib tem mobilizado vários investigadores na busca das possíveis explicações para esses eventos, bem como a identificação das medidas a serem implementadas para evitar o reaparecimento da doença.Conclusões: O uso da vacina conjugada para Hib em escala populacional tem sido extremamente efetivo. No entanto, mudanças no esquema vacinal poderão ser necessárias para a manutenção do controle da doença invasiva por Hib, frente ao atual cenário epidemiológico das infecções pelo Hib.J Pediatr (Rio J). 2006;82(3 Supl):S109-14: Haemophilus influenzae tipo b, imunização, vacina, meningite, pneumonia.Haemoph...

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Occurrence of Haemophylus influenzae B meningitis after the implementation of a mass vaccination program

Cited by 6 publications

References 7 publications

Vaccination herd effect experience in Latin America: a systematic literature review

Vaccination herd effect experience in Latin America: a systematic literature review

Evolution of bacterial meningitis diagnosis in Sao Paulo State-Brazil and future challenges

<i>Haemophilus influenzae</i> type b vaccination: long-term protection

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Occurrence of Haemophylus influenzae B meningitis after the implementation of a mass vaccination program

Cited by 6 publications

References 7 publications

Vaccination herd effect experience in Latin America: a systematic literature review

Vaccination herd effect experience in Latin America: a systematic literature review

Evolution of bacterial meningitis diagnosis in Sao Paulo State-Brazil and future challenges

&lt;i&gt;Haemophilus influenzae&lt;/i&gt; type b vaccination: long-term protection

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<i>Haemophilus influenzae</i> type b vaccination: long-term protection